Tumor Biology, 2017 Nerve fibers and neurotransmitters have increasingly been shown to have a role in tumor progression. Gastrin-releasing peptide is a neuropeptide linked to tumor aggressiveness, acting as an autocrine tumor growth factor by binding to its receptor ...
Natália Jaeger +4 more
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Human gastrin- releasing peptide receptor expression in women with uterine cervix cancer [PDF]
Frontiers in Oncology, 2023 Introduction212Pb-DOTAM-GRPR1 is a pharmaceutical radioimmunoconjugate consisiting of an α-particle-emitting radionuclide lead-212 (212Pb), a metal chelator DOTAM (1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane), and a gastrin ...
Charles A. Kunos +5 more
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In vitro gastrin-releasing peptide response in chicken ovarian follicles [PDF]
Poultry ScienceThe gastrin-releasing peptide (GRP) is reported to be mainly produced by the pituitary in chickens, with its receptor (GRPR) highly expressed in the ovaries, indicating its regulatory role in ovarian function. Present study aims to verify the role of GRP
Chunheng Mo +6 more
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Gastrin-releasing peptide receptor expression in gastrointestinal stromal tumours [PDF]
ESMO Gastrointestinal OncologyBackground: There are limited treatment options for patients with advanced or metastatic gastrointestinal stromal tumours (GISTs) that lack mutations targetable by tyrosine kinase inhibitors (TKIs) or that have developed resistance to TKIs.
M. Berndsen +6 more
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Gastrin-Releasing Peptide (GRP) Stimulates Osteoclastogenesis in Periodontitis [PDF]
Cells, 2020 Periodontitis is a chronic inflammatory disease with alveolar bone resorption and subsequent tooth loss as its ultimate outcomes. Gastrin-releasing peptide (GRP) is a neuropeptide with growth-stimulatory and tumorigenic properties, and neuropeptides have
YunJeong Choi +6 more
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Analgesic effect of gastrin-releasing peptide in the dorsal horn [PDF]
Molecular Pain, 2022 Itch and pain are both unpleasant, but they are discrete sensations. Both of these sensations are transmitted by C-fibers and processed in laminae I-II of the dorsal horn.
Ayano Saeki +4 more
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Gastrin‐Releasing Peptide Facilitates Cholinergically Mediated Contractions of the Mouse Gastric Fundus [PDF]
Pharmacology Research & PerspectivesGastrin‐releasing peptide (GRP) and neuromedin B (NMB) are found in the stomach's myenteric plexus and muscular layers. When exogenously administered, they contract stomach muscle in several species, but their ability to modulate enteric nerve functions ...
Diego Currò +2 more
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Photoacoustic signal enhancement in dual-contrast gastrin-releasing peptide receptor-targeted nanobubbles [PDF]
Frontiers in Bioengineering and Biotechnology, 2023 Translatable imaging agents are a crucial element of successful molecular imaging. Photoacoustic molecular imaging relies on optical absorbing materials to generate a sufficient signal.
Shensheng Zhao +11 more
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The gastrin-releasing peptide receptor as a potential biomarker for squamous cell carcinoma [PDF]
Scientific ReportsThe gastrin-releasing peptide receptor (GRPR) is expressed across multiple human cancer types, including head and neck tumors, and has also been detected in the oral mucosa of patients bearing head and neck neoplasms.
Danielly Brufatto Olguins +9 more
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Gastrin-releasing peptide is essential for generalization of auditory conditioned fear under stress [PDF]
Molecular BrainFear generalization, which allows animals to respond adaptively to cues similar to original threatening ones, is generally beneficial for survival. However, an inability to distinguish between threat and safety, leading to the overgeneralization of fear ...
Yi Wu +3 more
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