Results 1 to 10 of about 356 (108)

Inhibition of Gastrin-Releasing Peptide Attenuates Phosphate-Induced Vascular Calcification

Cells, 2020
Vascular calcification is the pathological deposition of calcium/phosphate in the vascular system and is closely associated with cardiovascular morbidity and mortality.
Hyun-Joo Park, Yeon Kim, Mi-Kyoung Kim, Jae Joon Hwang, Hyung Joon Kim, Soo-Kyung Bae, Moon-Kyoung Bae   +6 more
doaj   +3 more sources

Neuropeptide gastrin-releasing peptide induces PI3K/reactive oxygen species–dependent migration in lung adenocarcinoma cells

Tumor Biology, 2017
Nerve fibers and neurotransmitters have increasingly been shown to have a role in tumor progression. Gastrin-releasing peptide is a neuropeptide linked to tumor aggressiveness, acting as an autocrine tumor growth factor by binding to its receptor ...
Natália Jaeger, Rafael Sanguinetti Czepielewski, Maira Bagatini, Bárbara N Porto, Cristina Bonorino   +4 more
doaj   +2 more sources

Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target

Frontiers in Endocrinology, 2012
Neuropeptides acting on specific cell membrane receptors of the G protein-coupled receptor (GPCR) superfamily regulate a range of important aspects of nervous and neuroendocrine function.
Rafael eRoesler, Gilberto eSchwartsmann
doaj   +3 more sources

Improvement of autism spectrum disorder symptoms in three children by using gastrin-releasing peptide,

Jornal de Pediatria, 2016
Objective: To evaluate the safety, tolerability and potential therapeutic effects of gastrin-releasing peptide in three children with autistic spectrum disorder. Methods: Case series study with the intravenous administration of gastrin-releasing peptide
Michele Michelin Becker, Cleonice Bosa, Vera Lorentz Oliveira-Freitas, José Roberto Goldim, Lygia Ohlweiler, Rafael Roesler, Gilberto Schwartsmann, Rudimar dos Santos Riesgo   +7 more
doaj   +5 more sources

Evaluation of 99mTc-HYNIC-βAla-Bombesin(7-14) as an agent for pancreas tumor detection in mice [PDF]

Brazilian Journal of Medical and Biological Research, 2015
Pancreatic adenocarcinoma is important in oncology because of its high mortality rate. Deaths may be avoided if an early diagnosis could be achieved. Several types of tumors overexpress gastrin-releasing peptide receptors (GRPr), including pancreatic ...
F.N. Carlesso, L.L. Fuscaldi, R.S. Araújo, C.S. Teixeira, M.C. Oliveira, S.O.A. Fernandes, G.D. Cassali, D.C. Reis, A.L.B. Barros, V.N. Cardoso   +9 more
doaj   +3 more sources

Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch

Nature Communications, 2022
Gastrin-releasing peptide receptors (GRPR) are involved in pruriceptive behaviours. Here the authors show that neuronal pentraxin 2 upregulated in primary sensory neurons in chronic itch models is required for facilitating excitatory synaptic inputs onto
Kensho Kanehisa, Keisuke Koga, Sho Maejima, Yuto Shiraishi, Konatsu Asai, Miho Shiratori-Hayashi, Mei-Fang Xiao, Hirotaka Sakamoto, Paul F. Worley, Makoto Tsuda   +9 more
doaj   +1 more source

Gastrin-Releasing Peptide (GRP) Stimulates Osteoclastogenesis in Periodontitis

Cells, 2020
Periodontitis is a chronic inflammatory disease with alveolar bone resorption and subsequent tooth loss as its ultimate outcomes. Gastrin-releasing peptide (GRP) is a neuropeptide with growth-stimulatory and tumorigenic properties, and neuropeptides have
YunJeong Choi, Soon Chul Heo, Yu Na Kim, Ji-Young Joo, Jae Joon Hwang, Moon-Kyoung Bae, Hyung Joon Kim   +6 more
doaj   +1 more source

Gastrin releasing peptide and gastrin releasing peptide receptor expression in gastrointestinal carcinoid tumours [PDF]

Journal of Clinical Pathology, 2004
Aims: To establish whether gastrin releasing peptide (GRP) and the GRP receptor (GRPR) are expressed together in gastrointestinal carcinoid tumours. Methods: Twenty six carcinoid tumours from the stomach, small intestine, appendix, and
Scott, N., Millward, E., Cartwright, E. J.; id_orcid 0000-0002-6836-7795, Preston, S. R., Coletta, P. L.   +4 more
openaire   +2 more sources

CCK‐1 and CCK‐2 receptor agonism do not stimulate GLP‐1 and neurotensin secretion in the isolated perfused rat small intestine or GLP‐1 and PYY secretion in the rat colon

Physiological Reports, 2020
Gastrin and cholecystokinin (CCK) are hormones released from endocrine cells in the antral stomach (gastrin), the duodenum, and the jejunum (CCK). Recent reports, based on secretion experiments in an enteroendocrine cell line (NCI‐H716) and gastrin ...
Ida M. Modvig, Charlotte B. Christiansen, Jens F. Rehfeld, Jens J. Holst, Simon Veedfald   +4 more
doaj   +1 more source

ProGRP as early predictive marker of non–small-cell lung cancer to small-cell lung cancer transformation after EGFR-TKI treatment

Respiratory Medicine Case Reports, 2019
We report a case of non–small-cell lung cancer (NSCLC) to small-cell lung cancer (SCLC) transformation after epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment.
Yasuhiro Kato, Yosuke Tanaka, Mitsunori Hino, Akihiko Gemma   +3 more
doaj   +1 more source