Results 31 to 40 of about 619,655 (193)

Relationship of Serum Pro-Gastrin-Releasing Peptide with Kidney Fibrosis and Proteinuria

Turkish Journal of Nephrology
Background: Interstitial fibrosis/tubular atrophy (IFTA) plays a crucial role in the pathogenesis of chronic kidney disease. Pro-gastrin-releasing peptide (proGRP), a neuropeptide, plays a role in stimulating fibroblast activity. This study explores the
Muharrem Özden, Barış Eser, İbrahim Doğan, Nihal Aydemir, Aysel Çolak, Hüseyin Kayadibi, Gamze Kodalak Özil, Berkant Bebek, Alpaslan Karabulut   +8 more
doaj   +1 more source

Interaction between substance P and gastrin-releasing peptide on thyrotropin secretion by rat pituitary in vitro

Brazilian Journal of Medical and Biological Research, 1999
The effect of substance P (SP) on thyrotropin (TSH) secretion is controversial. In this study we evaluated the effect of SP on TSH secretion by hemipituitaries of 3-month-old Wistar rats in vitro and its interaction with gastrin-releasing peptide (GRP ...
E.G. Moura, C.V.M. Santos, R.M.M. Santos, C.C. Pazos-Moura   +3 more
doaj   +1 more source

Gastrin releasing peptide receptor mediates its morphogenic properties via ICAM-1 and Hsp72.

, 2009
Gastrin releasing peptide receptor mediates its morphogenic properties via ICAM-1 and ...
Lauren Nicole. Taglia (7988618)
core   +6 more sources

Preclinical Evaluation of the GRPR-Targeting Antagonist RM26 Conjugated to the Albumin-Binding Domain for GRPR-Targeting Therapy of Cancer

Pharmaceutics, 2020
The targeting of gastrin-releasing peptide receptors (GRPR) was recently proposed for targeted therapy, e.g., radiotherapy. Multiple and frequent injections of peptide-based therapeutic agents would be required due to rapid blood clearance.
Ayman Abouzayed, Hanna Tano, Ábel Nagy, Sara S. Rinne, Fadya Wadeea, Sharmishtaa Kumar, Kristina Westerlund, Vladimir Tolmachev, Amelie Eriksson Karlström, Anna Orlova   +9 more
doaj   +1 more source

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

Animal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen, Xiangfang Tang, Yimin Zhuang, Shengjun Zhao, Ying Ren, Xiaokang Lv   +5 more
wiley   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Radionuclide GRPR imaging in malignant pathology of the mammary and prostate glands: clinical experience

Бюллетень сибирской медицины
In this lecture, we presented current clinical studies on targeted radionuclide imaging of breast and prostate tumors with overexpression of the gastrin-releasing peptide receptor (GRPR). The gastrin-releasing peptide receptor is a transmembrane receptor,
O. D. Bragina, A. G. Ivanova, E. A. Usynin   +2 more
doaj   +1 more source

Targeting gastrin-releasing peptide suppresses neuroblastoma progression via upregulation of PTEN signaling. [PDF]

PLoS ONE, 2013
We have previously demonstrated the role of gastrin-releasing peptide (GRP) as an autocrine growth factor for neuroblastoma. Here, we report that GRP silencing regulates cell signaling involved in the invasion-metastasis cascade.
Pritha Paul, Jingbo Qiao, Kwang Woon Kim, Carmelle Romain, Sora Lee, Natasha Volny, Bret Mobley, Hernan Correa, Dai H Chung   +8 more
doaj   +1 more source

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

GRPR (Gastrin-Releasing Peptide Receptor) [PDF]

, 2014
Bombesin (BB) and gastrin-releasing peptide (GRP) bind with high affinity to the GRP-receptor (GRP-R) which regulates release of gastrointestinal hormones, smooth muscle contraction and proliferation of epithelial as well as cancer cells.
Moody, TW
core   +1 more source