Results 31 to 40 of about 375 (127)

Ets1 Transcription Factor Mediates Gastrin-Releasing Peptide-Induced IL-8 Regulation in Neuroblastoma Cells

Neoplasia: An International Journal for Oncology Research, 2007
Angiogenesis plays a critical role in tumor progression in various cancers, including neuroblastoma. We have previously shown that gastrin-releasing peptide (GRP) stimulates neuroblastoma growth and that its cell surface receptors, gastrin-releasing ...
Jingbo Qiao, Jung-Hee Kang, Jeremy Cree, B. Mark Evers, Dai H. Chung   +4 more
doaj   +1 more source

Real‐World Prognostic Analysis of Clinical Characteristics in Extensive‐Stage Small Cell Lung Cancer: A Nomogram for Survival Prediction in Patients Receiving First‐Line Immunochemotherapy With Serplulimab

Cancer Medicine, Volume 15, Issue 8, August 2026.
Among 239 patients reviewed, 109 patients with extensive‐stage small‐cell lung cancer receiving first‐line serplulimab‐based immunochemotherapy were included. A nomogram incorporating liver metastasis, maintenance therapy, albumin, and neutrophil‐to‐lymphocyte ratio predicted overall survival and significantly stratified patients into three risk groups
Ying Zhu, Zhongwen Li, Ming Zhang, Yuyun Lan, Yarong Wang, Yao Liu, Yibing Liu   +6 more
wiley   +1 more source

Gastrin-releasing peptide induces fibrotic response in MRC5s and proliferation in A549s

Cell Communication and Signaling, 2020
Idiopathic pulmonary fibrosis (IPF) is a complex lung disease, whose build-up scar tissue is induced by several molecules. Gastrin-releasing peptide (GRP) is released from pulmonary neuroendocrine cells, alveolar macrophages, and some nerve endings in ...
Ozgecan Kayalar, Fusun Oztay, Hurrem Gul Ongen   +2 more
doaj   +1 more source

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković, Strahinja Pešić, Marija Novaković, Anđela Dubroja Krstić, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Bombesin Receptor Family Activation and CNS/Neural Tumors: Review of Evidence Supporting Possible Role for Novel Targeted Therapy

Frontiers in Endocrinology, 2021
G-protein-coupled receptors (GPCRs) are increasingly being considered as possible therapeutic targets in cancers. Activation of GPCR on tumors can have prominent growth effects, and GPCRs are frequently over-/ectopically expressed on tumors and thus can ...
Terry W. Moody, Lingaku Lee, Lingaku Lee, Irene Ramos-Alvarez, Tatiana Iordanskaia, Samuel A. Mantey, Robert T. Jensen   +6 more
doaj   +1 more source

Small Cell Lung Cancer Associated With Cystic Airspace: A Case Report and Literature Review

Respirology Case Reports, Volume 14, Issue 8, August 2026.
We report a rare case of small cell lung cancer (SCLC) associated with a cystic airspace. Chest CT revealed a solid tumour component arising from the wall of a pre‐existing lung cyst. This case highlights the clinical importance of recognising cystic airspaces as potential sites for aggressive malignancies like SCLC.
Hiroyuki Shimada, Yukihisa Inoue, Osamu Matsubara, Mio Yamamoto, Shohei Yamashita, Tetsu Hara, Kazuki Yamanaka, Yasuto Jinn   +7 more
wiley   +1 more source

Evolution of the Jawed Vertebrate (Gnathostomata) Stomach Through Gene Repertoire Loss: Findings from Agastric Species

Journal of Developmental Biology
The stomach has been a highly conserved organ throughout vertebrate evolution; however, there are now over 20 lineages composed of monotremes, lungfish and teleost fish displaying a secondary loss of stomach function and morphology.
Jackson Dann, Frank Grützner
doaj   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice

Cell Reports, 2018
Summary: Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive.
Admire Munanairi, Xian-Yu Liu, Devin M. Barry, Qianyi Yang, Jun-Bin Yin, Hua Jin, Hui Li, Qing-Tao Meng, Jia-Hang Peng, Zhen-Yu Wu, Jun Yin, Xuan-Yi Zhou, Li Wan, Ping Mo, Seungil Kim, Fu-Quan Huo, Joseph Jeffry, Yun-Qing Li, Rita Bardoni, Michael R. Bruchas, Zhou-Feng Chen   +20 more
doaj   +1 more source

Effect of Chewing Gum on Bowel Function Recovery in Elderly Patients Following Posterior Lumbar Fusion Surgery: A Randomized Controlled Trial

Orthopaedic Surgery, Volume 18, Issue 8, Page 1641-1648, August 2026.
Chewing gum did not improve early bowel recovery after lumbar fusion. ABSTRACT Objective Given the paucity of prospective randomized evidence on chewing gum for postoperative bowel recovery in elderly spinal fusion patients, this study aimed to assess the efficacy of chewing gum in improving bowel function recovery in the elderly after posterior lumbar
Fuze Liu, Yifei Li, Gaoyang Li, Xiaoyan He, Lin Zhang, Meijia Zhang, Tian Liu, Ying Jiang, Qinlu Wang, Yaping Chen, Hai Wang   +10 more
wiley   +1 more source