Results 51 to 60 of about 619,655 (193)
Frontiers in Endocrinology, 2021 G-protein-coupled receptors (GPCRs) are increasingly being considered as possible therapeutic targets in cancers. Activation of GPCR on tumors can have prominent growth effects, and GPCRs are frequently over-/ectopically expressed on tumors and thus can ...
Terry W. Moody +6 more
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Respirology Case Reports, Volume 14, Issue 10, October 2026.Pulmonary tumour thrombotic microangiopathy (PTTM) is a rapidly fatal condition that is rarely diagnosed during life. Early clinical recognition and prompt nivolumab treatment resulted in long‐term survival in a patient with cancer of unknown primary‐associated PTTM.
Kosuke Fujishima +4 more
wiley +1 more source
Journal of Developmental BiologyThe stomach has been a highly conserved organ throughout vertebrate evolution; however, there are now over 20 lineages composed of monotremes, lungfish and teleost fish displaying a secondary loss of stomach function and morphology.
Jackson Dann, Frank Grützner
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Small, Volume 22, Issue 55, 1 October 2026.This study discriminates between sulfated and unsulfated cholecystokinin‐8 gut‐hormone forms at single‐molecule‐level resolution. Using an aerolysin nanopore embedded in a hybrid lipid‐polymer membrane, the system produces distinct electrical signatures enabling highly sensitive detection, even in 20% human serum.
Luca Iesu +3 more
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Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.Piezo1 functions as a context‐dependent mechanotransduction node linking mechanical cues to inflammation, tissue remodelling and metabolic regulation in digestive homeostasis and disease. In epithelial, immune, stromal and endocrine cells, Piezo1‐mediated Ca2+ signalling contributes to barrier and mucus homeostasis, epithelial renewal and repair ...
Yuan Xia +6 more
wiley +1 more source
Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice
Cell Reports, 2018 Summary: Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive.
Admire Munanairi +20 more
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Penile Metastasis From Castration‐Resistant Prostate Cancer: A Case Report
IJU Case Reports, Volume 9, Issue 5, September 2026.ABSTRACT Introduction Penile metastasis from prostate cancer—generally associated with a poor prognosis—is rare and underreported. We report one relevant case. Case Presentation The patient was a 65‐year‐old male with metastatic hormone‐sensitive prostate cancer (prostate‐specific antigen [PSA]: 500 ng/mL) and lung, bone, and lymph node metastases. The
Satoshi Asakura +8 more
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Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.Med reduces pyroptosis in LPS‐induced THLE‐2 cells by inactivating NLRP3/GSDMD/caspase‐1, thereby exerting a protective effect in sepsis‐induced liver injury. ABSTRACT The liver is a decisive organ that is damaged by sepsis. Medicarpin (Med) is a principal wing‐type final product of 5‐deoxyisoflavone sub‐branch in M.
Pengfei Chen, Weifeng Jiang
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British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan +3 more
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, 2011 Bombesin receptors are overexpressed on a variety of human tumors. In particular, the gastrin-releasing peptide receptor (GRPr) has been identified on prostate and breast cancers and on gastrointestinal stromal tumors.
Keelara Abiraj +22 more
core +1 more source