Results 61 to 70 of about 619,655 (193)

Targeting rectal cancer using fluorescent nanoparticles conjugated to a novel GRPR-Binding peptide for tumor imaging applications

Materials & Design
Surgical treatment of rectal cancer is difficult due to anatomical complexity. To improve tumor resection, fluorescence-guided surgery (FGS) has been developed using near-infrared fluorescence (NIRF, approximately 800 nm) and a dedicated camera system ...
Somayeh Rezaei, Mark Fonteyne, Luis J. Cruz, Nada Badr, Ajinkya Manelkar, Mahin Saberi, Ronald L.P. van Vlierberghe, Alexander L. Vahrmeijer, Christina Eich, Fernando Albericio, Louise. van der Weerd, Peter J.K. Kuppen   +11 more
doaj   +1 more source

Real‐World Prognostic Analysis of Clinical Characteristics in Extensive‐Stage Small Cell Lung Cancer: A Nomogram for Survival Prediction in Patients Receiving First‐Line Immunochemotherapy With Serplulimab

Cancer Medicine, Volume 15, Issue 8, August 2026.
Among 239 patients reviewed, 109 patients with extensive‐stage small‐cell lung cancer receiving first‐line serplulimab‐based immunochemotherapy were included. A nomogram incorporating liver metastasis, maintenance therapy, albumin, and neutrophil‐to‐lymphocyte ratio predicted overall survival and significantly stratified patients into three risk groups
Ying Zhu, Zhongwen Li, Ming Zhang, Yuyun Lan, Yarong Wang, Yao Liu, Yibing Liu   +6 more
wiley   +1 more source

Supplementary_Table_1 – Supplemental material for Establishment of the reference interval for serum pro-gastrin-releasing peptide in healthy adults of Chinese Han ethnicity

, 2018
Supplemental material, Supplementary_Table_1 for Establishment of the reference interval for serum pro-gastrin-releasing peptide in healthy adults of Chinese Han ethnicity by Bing Zhao, Miaomiao Zhang, Feng Lin, Jing Xie, Yan Liang and Zaixing Yang in ...
Jing Xie (180526), Bing Zhao (29538), Yan Liang (139654), Miaomiao Zhang (170754), Feng Lin (23861), Zaixing Yang (172382)   +5 more
core   +1 more source

Targeting the gastrin-releasing peptide receptor pathway to treat cognitive dysfunction associated with Alzheimer's Disease

Dementia & Neuropsychologia
Increasing evidence indicates that bombesin (BB)-like peptides (BLPs), such as the gastrin-releasing peptide (GRP) and its receptor (GRPR), might play a role in neurological and psychiatric disorders.
Rafael Roesler, Tatiana Luft, Gilberto Schwartsmann   +2 more
doaj   +1 more source

Stress and eating: A dual role for bombesin-like peptides

Frontiers in Neuroscience, 2013
The current obesity ‘epidemic’ in the developed world is a major health concern; over half of adult Canadians are now classified as overweight or obese.
Zul eMerali, Samantha eGraitson, Jennifer Christine Mackay, Pamela eKent   +3 more
doaj   +1 more source

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković, Strahinja Pešić, Marija Novaković, Anđela Dubroja Krstić, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Precision Theranostics in Nuclear Medicine Targeting Gastrin-Releasing Peptide Receptor

Xiehe Yixue Zazhi
The gastrin-releasing peptide receptor (GRPR) is highly expressed in various malignant tumors (e.g., glioblastoma, prostate cancer, and breast cancer) and has emerged as an important molecular target for precision cancer diagnosis and therapy.
WANG Rongxi, ZHU Zhaohui, CHEN Xiaoyuan
doaj   +1 more source

Small Cell Lung Cancer Associated With Cystic Airspace: A Case Report and Literature Review

Respirology Case Reports, Volume 14, Issue 8, August 2026.
We report a rare case of small cell lung cancer (SCLC) associated with a cystic airspace. Chest CT revealed a solid tumour component arising from the wall of a pre‐existing lung cyst. This case highlights the clinical importance of recognising cystic airspaces as potential sites for aggressive malignancies like SCLC.
Hiroyuki Shimada, Yukihisa Inoue, Osamu Matsubara, Mio Yamamoto, Shohei Yamashita, Tetsu Hara, Kazuki Yamanaka, Yasuto Jinn   +7 more
wiley   +1 more source

Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord

Nature Communications
Itch is a common side effect of opioid analgesics. The specific neurons mediating opioid-induced itch are still debated, and the mechanistic neuronal circuits remain elusive.
Qian Zeng, Yitong Li, Yifei Wu, Jiawei Wu, Kangtai Xu, Yiming Chen, Yunfei Rao, Nan Li, Yuhui Luo, Changyu Jiang, Chaoran Wu, Zilong Wang   +11 more
doaj   +1 more source

Peptide‐based responsive molecular fluorescent probes for precision oncology

Responsive Materials, Volume 4, Issue 3, August 2026.
Peptide‐based responsive fluorescent probes have emerged as adaptive functional materials for precision tumor theranostics, combining tumor‐selective recognition, programmable stimulus responsiveness, and modular tunability. They enable high‐contrast imaging, intraoperative guidance, real‐time monitoring, and multimodal applications, while next ...
Xing Wang, Wen Liu, Jiahao Zhang, Wanqi Wang, Zhicheng Jin, Yuqi Tang, Quan Li   +6 more
wiley   +1 more source