Results 41 to 50 of about 375 (127)

Supraspinal Circuit Mechanisms Underlying Itch Processing

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Peripheral pruriceptive signals ascend from the spinal cord to the brainstem, thalamus, and cortex to encode the sensory features of itch. Parallel projections to limbic and basal ganglia circuits mediate affective and motivational components, including aversion and scratching urge.
Yuncheng Luo, Hao‐Di Tang, Ping Liao, Ruotian Jiang   +3 more
wiley   +1 more source

Neuroendocrine Transformation Without PSA Elevation in High‐Risk Metastatic Castration‐Sensitive Prostate Cancer Under Androgen Receptor Signaling Inhibition: A Case Report

IJU Case Reports, Volume 9, Issue 4, July 2026.
ABSTRACT Introduction Neuroendocrine prostate cancer is a rare and highly aggressive variant of prostate cancer with a poor prognosis. We report a case in which metastatic castration‐sensitive prostate cancer directly transformed into neuroendocrine prostate cancer without a corresponding increase in prostate‐specific antigen.
Yoshihiro Nakagami, Shintaro Ohnuma, Masashi Tamaoka, Tatsuki Inoue, Motoki Yamagishi, Kazuhiko Oshinomi, Masakazu Nagata, Yasuyuki Oohira, Toshiko Yamochi, Takashi Fukagai   +9 more
wiley   +1 more source

Gastrin-releasing peptide receptor expression in gastrointestinal stromal tumours

ESMO Gastrointestinal Oncology
Background: There are limited treatment options for patients with advanced or metastatic gastrointestinal stromal tumours (GISTs) that lack mutations targetable by tyrosine kinase inhibitors (TKIs) or that have developed resistance to TKIs.
M. Berndsen, F. Puls, A. Thornell, Y. Arvidsson, A. Muth, S. Lindskog, E. Elias   +6 more
doaj   +1 more source

Radiation‐Associated Enteric‐Type Urethral Adenocarcinoma 20 Years After Prostate Brachytherapy: A Case Treated With Neoadjuvant Gemcitabine‐Cisplatin and Robot‐Assisted Radical Cystectomy

IJU Case Reports, Volume 9, Issue 4, July 2026.
ABSTRACT Introduction Brachytherapy is a widely accepted treatment for prostate cancer, in which subsequent radiation‐associated enteric‐type urethral adenocarcinoma is extremely rare. Case Presentation An 83‐year‐old man with a history of cholecystitis, appendicitis, and hyperlipidemia who had undergone brachytherapy 20 years earlier presented with ...
Yuki Tanaka, Yui Fujimura, Koya Morishita, Yuta Kashiwagi, Satoshi Katsuno, Tatsuya Nagai, Yuki Okumura   +6 more
wiley   +1 more source

Targeting the gastrin-releasing peptide receptor pathway to treat cognitive dysfunction associated with Alzheimer's Disease

Dementia & Neuropsychologia
Increasing evidence indicates that bombesin (BB)-like peptides (BLPs), such as the gastrin-releasing peptide (GRP) and its receptor (GRPR), might play a role in neurological and psychiatric disorders.
Rafael Roesler, Tatiana Luft, Gilberto Schwartsmann   +2 more
doaj   +1 more source

Initial Dose Tarlatamab–Associated Tumour Lysis Syndrome in Small Cell Lung Cancer: A Case Report

Respirology Case Reports, Volume 14, Issue 7, July 2026.
We report a fatal case of acute TLS following a single 1‐mg dose of tarlatamab in a patient with relapsed SCLC with extensive liver metastases. This case highlights the importance of TLS risk assessment prior to tarlatamab treatment. Extensive liver metastases and elevated lactate dehydrogenase levels may be risk factors for TLS in patients with SCLC ...
Katsuhiko Shibata, Hiromu Tanaka, Yusuke Arai, Yusuke Watanuki, Takashi Kokubo, Yo Watanabe, Shingo Nakayama, Takahiro Asami, Takashi Inoue   +8 more
wiley   +1 more source

Targeting rectal cancer using fluorescent nanoparticles conjugated to a novel GRPR-Binding peptide for tumor imaging applications

Materials & Design
Surgical treatment of rectal cancer is difficult due to anatomical complexity. To improve tumor resection, fluorescence-guided surgery (FGS) has been developed using near-infrared fluorescence (NIRF, approximately 800 nm) and a dedicated camera system ...
Somayeh Rezaei, Mark Fonteyne, Luis J. Cruz, Nada Badr, Ajinkya Manelkar, Mahin Saberi, Ronald L.P. van Vlierberghe, Alexander L. Vahrmeijer, Christina Eich, Fernando Albericio, Louise. van der Weerd, Peter J.K. Kuppen   +11 more
doaj   +1 more source

Stress and eating: A dual role for bombesin-like peptides

Frontiers in Neuroscience, 2013
The current obesity ‘epidemic’ in the developed world is a major health concern; over half of adult Canadians are now classified as overweight or obese.
Zul eMerali, Samantha eGraitson, Jennifer Christine Mackay, Pamela eKent   +3 more
doaj   +1 more source

Atypical Behavior in a Typical Carcinoid: When Minimal Proliferation Meets Lympho‐Vascular Invasion—A Case Report

Thoracic Cancer, Volume 17, Issue 14, July 2026.
Left: A 46‐year‐old non‐smoking female with a 2.4 cm right hilar mass (cT1cN0M0). Middle: Postoperative pathology reveals discordance between low proliferation (Ki‐67 < 2%) and unexpected focal lympho‐vascular invasion, with concomitant granulomatous inflammation. Right: After VATS lobectomy (pN0) and active surveillance, no recurrence occurred over 20 
Qilian Wang, Xi Chen, Sicheng Zhou, Guowei Che   +3 more
wiley   +1 more source

Precision Theranostics in Nuclear Medicine Targeting Gastrin-Releasing Peptide Receptor

Xiehe Yixue Zazhi
The gastrin-releasing peptide receptor (GRPR) is highly expressed in various malignant tumors (e.g., glioblastoma, prostate cancer, and breast cancer) and has emerged as an important molecular target for precision cancer diagnosis and therapy.
WANG Rongxi, ZHU Zhaohui, CHEN Xiaoyuan
doaj   +1 more source