Results 21 to 30 of about 619,655 (193)

CCK‐1 and CCK‐2 receptor agonism do not stimulate GLP‐1 and neurotensin secretion in the isolated perfused rat small intestine or GLP‐1 and PYY secretion in the rat colon

Physiological Reports, 2020
Gastrin and cholecystokinin (CCK) are hormones released from endocrine cells in the antral stomach (gastrin), the duodenum, and the jejunum (CCK). Recent reports, based on secretion experiments in an enteroendocrine cell line (NCI‐H716) and gastrin ...
Ida M. Modvig, Charlotte B. Christiansen, Jens F. Rehfeld, Jens J. Holst, Simon Veedfald   +4 more
doaj   +1 more source

Development and analytical performance evaluation of an automated chemiluminescent immunoassay for pro-gastrin releasing peptide (ProGRP) [PDF]

, 2009
Background: Pro-gastrin releasing peptide ( ProGRP) concentrations in blood play an important role in the diagnosis and treatment of patients with small cell lung cancer (SCLC).
Patil, Rahul D., Dowell, Barry L., Iizuka, Masayuki, Yamaguchi, Ken, Chan, Sabrina S., Kinukawa, Hideki, Chan, Daniel W., Hofmann, Karin, Stieber, Petra, Sakurai, Yousuke, Yoshimura, Toru, Matsuoka, Yoshiharu, Sokoll, Lori, Scheuer, Cornelia, Saegusa, Haruhisa, Fujita, Kenju, Beligere, Gangamani S., Elliott, Debra   +17 more
core   +1 more source

ProGRP as early predictive marker of non–small-cell lung cancer to small-cell lung cancer transformation after EGFR-TKI treatment

Respiratory Medicine Case Reports, 2019
We report a case of non–small-cell lung cancer (NSCLC) to small-cell lung cancer (SCLC) transformation after epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment.
Yasuhiro Kato, Yosuke Tanaka, Mitsunori Hino, Akihiko Gemma   +3 more
doaj   +1 more source

CEA, CYFRA 21-1, NSE, and ProGRP in the diagnosis of lung cancer: a multivariate approach [PDF]

, 2008
We retrospectively studied the single and combined diagnostic value of carcinoembryonic antigen (CEA), cytokeratin fragment 19 (CYFRA 21-1), neuron specific enolase (NSE) and pro-gastrin-releasing peptide (ProGRP), which were routinely analysed in ...
Gruber, Christine, Hatz, Rudolf, Reinmiedl, Judith, Stieber, Petra, Nagel, Dorothea   +4 more
core   +1 more source

Bombesin receptor-targeted liposomes for enhanced delivery to lung cancer cells

Beilstein Journal of Nanotechnology, 2019
Background: Gastrin-releasing peptide is a member of the bombesin family of peptides. Its cognate receptor, gastrin releasing peptide receptor (GRPR), is widely expressed in cancers of the lung, pancreas and ovaries. Gastrin releasing peptide (GRP) is an
Mohammad J. Akbar, Pâmela C. Lukasewicz Ferreira, Melania Giorgetti, Leanne Stokes, Christopher J. Morris   +4 more
doaj   +1 more source

Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target

Frontiers in Endocrinology, 2012
Neuropeptides acting on specific cell membrane receptors of the G protein-coupled receptor (GPCR) superfamily regulate a range of important aspects of nervous and neuroendocrine function.
Rafael eRoesler, Gilberto eSchwartsmann
doaj   +1 more source

Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy. [PDF]

Proc Natl Acad Sci U S A, 2023
Gastrin releasing peptide receptor (GRPR), a member of the bombesin (BBN) G protein-coupled receptors, is aberrantly overexpressed in several malignant tumors, including those of the breast, prostate, pancreas, lung, and central nervous system ...
Peng S, Zhan Y, Zhang D, Ren L, Chen A, Chen ZF, Zhang H.   +6 more
europepmc   +2 more sources

Radiolabeled iron oxide nanoparticles functionalized with PSMA/BN ligands for dual-targeting of prostate cancer

Frontiers in Nuclear Medicine, 2023
IntroductionProstate cancer (PCa) is the second most frequent cancer diagnosis in men and the fifth leading cause of death worldwide. Prostate Specific Membrane Antigen (PSMA) and Gastrin Releasing Peptide (GRP) receptors are overexpressed in PCa.
Danae Efremia Bajwa, Evangelia-Alexandra Salvanou, Maria Theodosiou, Theodora S. Koutsikou, Theodora S. Koutsikou, Eleni K. Efthimiadou, Penelope Bouziotis, Christos Liolios, Christos Liolios   +8 more
doaj   +1 more source

A spinal neural circuitry for converting touch to itch sensation

Nature Communications, 2020
Light touch can sometimes induce unpleasant itch sensation but the neural correlates of this conversion are not well studied. Here, the authors provide evidence that Tac2 expressing spinal interneurons are connected to gastrin-releasing peptide receptor (
Sihan Chen, Xiao-Fei Gao, Yuxi Zhou, Ben-Long Liu, Xian-Yu Liu, Yufen Zhang, Devin M. Barry, Kun Liu, Yingfu Jiao, Rita Bardoni, Weifeng Yu, Zhou-Feng Chen   +11 more
doaj   +1 more source

Copper-67-Labeled Bombesin Peptide for Targeted Radionuclide Therapy of Prostate Cancer

Pharmaceuticals, 2022
The gastrin-releasing peptide receptor (GRPR) is a promising molecular target for imaging and therapy of prostate cancer using bombesin peptides that bind to the receptor with high affinity. Targeted copper theranostics (TCTs) using copper radionuclides,
Truc T. Huynh, Ellen M. van Dam, Sreeja Sreekumar, Cedric Mpoy, Benjamin J. Blyth, Fenella Muntz, Matthew J. Harris, Buck E. Rogers   +7 more
doaj   +1 more source