Results 11 to 20 of about 375 (127)

Human gastrin- releasing peptide receptor expression in women with uterine cervix cancer

Frontiers in Oncology, 2023
Introduction212Pb-DOTAM-GRPR1 is a pharmaceutical radioimmunoconjugate consisiting of an α-particle-emitting radionuclide lead-212 (212Pb), a metal chelator DOTAM (1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane), and a gastrin ...
Charles A. Kunos, Denise Fabian, Dana Napier, Mark S. Stonecypher, Ravyn M. Duncan, Jason Hurt   +5 more
doaj   +1 more source

Analgesic effect of gastrin-releasing peptide in the dorsal horn

Molecular Pain, 2022
Itch and pain are both unpleasant, but they are discrete sensations. Both of these sensations are transmitted by C-fibers and processed in laminae I-II of the dorsal horn.
Ayano Saeki, Hiroki Yamanaka, Kimiko Kobayashi, Masamichi Okubo, Koichi Noguchi   +4 more
doaj   +1 more source

Bombesin receptor-targeted liposomes for enhanced delivery to lung cancer cells

Beilstein Journal of Nanotechnology, 2019
Background: Gastrin-releasing peptide is a member of the bombesin family of peptides. Its cognate receptor, gastrin releasing peptide receptor (GRPR), is widely expressed in cancers of the lung, pancreas and ovaries. Gastrin releasing peptide (GRP) is an
Mohammad J. Akbar, Pâmela C. Lukasewicz Ferreira, Melania Giorgetti, Leanne Stokes, Christopher J. Morris   +4 more
doaj   +1 more source

A spinal neural circuitry for converting touch to itch sensation

Nature Communications, 2020
Light touch can sometimes induce unpleasant itch sensation but the neural correlates of this conversion are not well studied. Here, the authors provide evidence that Tac2 expressing spinal interneurons are connected to gastrin-releasing peptide receptor (
Sihan Chen, Xiao-Fei Gao, Yuxi Zhou, Ben-Long Liu, Xian-Yu Liu, Yufen Zhang, Devin M. Barry, Kun Liu, Yingfu Jiao, Rita Bardoni, Weifeng Yu, Zhou-Feng Chen   +11 more
doaj   +1 more source

Radiolabeled iron oxide nanoparticles functionalized with PSMA/BN ligands for dual-targeting of prostate cancer

Frontiers in Nuclear Medicine, 2023
IntroductionProstate cancer (PCa) is the second most frequent cancer diagnosis in men and the fifth leading cause of death worldwide. Prostate Specific Membrane Antigen (PSMA) and Gastrin Releasing Peptide (GRP) receptors are overexpressed in PCa.
Danae Efremia Bajwa, Evangelia-Alexandra Salvanou, Maria Theodosiou, Theodora S. Koutsikou, Theodora S. Koutsikou, Eleni K. Efthimiadou, Penelope Bouziotis, Christos Liolios, Christos Liolios   +8 more
doaj   +1 more source

Copper-67-Labeled Bombesin Peptide for Targeted Radionuclide Therapy of Prostate Cancer

Pharmaceuticals, 2022
The gastrin-releasing peptide receptor (GRPR) is a promising molecular target for imaging and therapy of prostate cancer using bombesin peptides that bind to the receptor with high affinity. Targeted copper theranostics (TCTs) using copper radionuclides,
Truc T. Huynh, Ellen M. van Dam, Sreeja Sreekumar, Cedric Mpoy, Benjamin J. Blyth, Fenella Muntz, Matthew J. Harris, Buck E. Rogers   +7 more
doaj   +1 more source

Relationship of Serum Pro-Gastrin-Releasing Peptide with Kidney Fibrosis and Proteinuria

Turkish Journal of Nephrology
Background: Interstitial fibrosis/tubular atrophy (IFTA) plays a crucial role in the pathogenesis of chronic kidney disease. Pro-gastrin-releasing peptide (proGRP), a neuropeptide, plays a role in stimulating fibroblast activity. This study explores the
Muharrem Özden, Barış Eser, İbrahim Doğan, Nihal Aydemir, Aysel Çolak, Hüseyin Kayadibi, Gamze Kodalak Özil, Berkant Bebek, Alpaslan Karabulut   +8 more
doaj   +1 more source

Interaction between substance P and gastrin-releasing peptide on thyrotropin secretion by rat pituitary in vitro

Brazilian Journal of Medical and Biological Research, 1999
The effect of substance P (SP) on thyrotropin (TSH) secretion is controversial. In this study we evaluated the effect of SP on TSH secretion by hemipituitaries of 3-month-old Wistar rats in vitro and its interaction with gastrin-releasing peptide (GRP ...
E.G. Moura, C.V.M. Santos, R.M.M. Santos, C.C. Pazos-Moura   +3 more
doaj   +1 more source

Preclinical Evaluation of the GRPR-Targeting Antagonist RM26 Conjugated to the Albumin-Binding Domain for GRPR-Targeting Therapy of Cancer

Pharmaceutics, 2020
The targeting of gastrin-releasing peptide receptors (GRPR) was recently proposed for targeted therapy, e.g., radiotherapy. Multiple and frequent injections of peptide-based therapeutic agents would be required due to rapid blood clearance.
Ayman Abouzayed, Hanna Tano, Ábel Nagy, Sara S. Rinne, Fadya Wadeea, Sharmishtaa Kumar, Kristina Westerlund, Vladimir Tolmachev, Amelie Eriksson Karlström, Anna Orlova   +9 more
doaj   +1 more source

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

Animal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen, Xiangfang Tang, Yimin Zhuang, Shengjun Zhao, Ying Ren, Xiaokang Lv   +5 more
wiley   +1 more source