Results 31 to 40 of about 6,216 (159)

Bombesin receptor-targeted liposomes for enhanced delivery to lung cancer cells

Beilstein Journal of Nanotechnology, 2019
Background: Gastrin-releasing peptide is a member of the bombesin family of peptides. Its cognate receptor, gastrin releasing peptide receptor (GRPR), is widely expressed in cancers of the lung, pancreas and ovaries. Gastrin releasing peptide (GRP) is an
Mohammad J. Akbar, Pâmela C. Lukasewicz Ferreira, Melania Giorgetti, Leanne Stokes, Christopher J. Morris   +4 more
doaj   +1 more source

GRPR (Gastrin-Releasing Peptide Receptor) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014
Bombesin (BB) and gastrin-releasing peptide (GRP) bind with high affinity to the GRP-receptor (GRP-R) which regulates release of gastrointestinal hormones, smooth muscle contraction and proliferation of epithelial as well as cancer cells. The GRP-R is a G-protein coupled receptor (GPCR) which activates phospholipase C signaling pathways.
openaire   +2 more sources

Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target

Frontiers in Endocrinology, 2012
Neuropeptides acting on specific cell membrane receptors of the G protein-coupled receptor (GPCR) superfamily regulate a range of important aspects of nervous and neuroendocrine function.
Rafael eRoesler, Gilberto eSchwartsmann
doaj   +1 more source

New Frontiers in Molecular Imaging Using Peptide-Based Radiopharmaceuticals for Prostate Cancer

Frontiers in Chemistry, 2020
The high incidence of prostate cancer (PCa) increases the need for progress in its diagnosis, staging, and precise treatment. The overexpression of tumor-specific receptors for peptides in human cancer cells, such as gastrin-releasing peptide receptor ...
Xin Li, Huawei Cai, Xiaoai Wu, Li Li, Haoxing Wu, Rong Tian   +5 more
doaj   +1 more source

Direct Observation of Endocytosis of Gastrin Releasing Peptide and Its Receptor [PDF]

Journal of Biological Chemistry, 1995
Endocytosis of the gastrin releasing peptide receptor (GRP-R) may regulate cellular responses to GRP. We observed endocytosis in transfected epithelial cells by confocal microscopy using cyanine 3-GRP (cyanine 3.18-labeled gastrin releasing peptide) and GRP-R antibodies. At 4 degrees C, cy3-GRP and GRP-R were confined to the plasma membrane.
E F, Grady, L W, Slice, W O, Brant, J H, Walsh, D G, Payan, N W, Bunnett   +5 more
openaire   +2 more sources

Involvement of Gastrin-Releasing Peptide Receptor in the Regulation of Adipocyte Differentiation in 3T3-L1 Cells. [PDF]

Int J Mol Sci, 2018
Kim MK, Park HJ, Kim Y, Bae SK, Kim HJ, Bae MK.   +5 more
europepmc   +2 more sources

Expression of gastrin-releasing peptide receptor in human skin.

Acta Dermato-Venereologica, 1996
Bombesin-related peptides are expressed in the skin of batrachians and mammals. As gastrin-releasing peptide belongs to this family, we searched for the presence and distribution of gastrin-releasing peptide receptors (GRPr) in the skin of healthy human adults by immunohistochemistry, flow cytometry and electron microscopy.
Staniek, V., Misery, L., Peguet-Navarro, J., Sabido, O., Cuber, J.C., Dezutter-Dambuyant, C., Claudy, A., Schmitt, D.   +7 more
openaire   +3 more sources

Lasting and Sex-Dependent Impact of Maternal Immune Activation on Molecular Pathways of the Amygdala

Frontiers in Neuroscience, 2020
The prolonged and sex-dependent impact of maternal immune activation (MIA) during gestation on the molecular pathways of the amygdala, a brain region that influences social, emotional, and other behaviors, is only partially understood.
Marissa R. Keever, Pan Zhang, Courtni R. Bolt, Adrienne M. Antonson, Haley E. Rymut, Megan P. Caputo, Alexandra K. Houser, Alvaro G. Hernandez, Bruce R. Southey, Laurie A. Rund, Rodney W. Johnson, Rodney W. Johnson, Sandra L. Rodriguez-Zas, Sandra L. Rodriguez-Zas, Sandra L. Rodriguez-Zas, Sandra L. Rodriguez-Zas, Sandra L. Rodriguez-Zas   +16 more
doaj   +1 more source

Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice

Cell Reports, 2018
Summary: Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive.
Admire Munanairi, Xian-Yu Liu, Devin M. Barry, Qianyi Yang, Jun-Bin Yin, Hua Jin, Hui Li, Qing-Tao Meng, Jia-Hang Peng, Zhen-Yu Wu, Jun Yin, Xuan-Yi Zhou, Li Wan, Ping Mo, Seungil Kim, Fu-Quan Huo, Joseph Jeffry, Yun-Qing Li, Rita Bardoni, Michael R. Bruchas, Zhou-Feng Chen   +20 more
doaj   +1 more source

Preclinical Evaluation of the GRPR-Targeting Antagonist RM26 Conjugated to the Albumin-Binding Domain for GRPR-Targeting Therapy of Cancer

Pharmaceutics, 2020
The targeting of gastrin-releasing peptide receptors (GRPR) was recently proposed for targeted therapy, e.g., radiotherapy. Multiple and frequent injections of peptide-based therapeutic agents would be required due to rapid blood clearance.
Ayman Abouzayed, Hanna Tano, Ábel Nagy, Sara S. Rinne, Fadya Wadeea, Sharmishtaa Kumar, Kristina Westerlund, Vladimir Tolmachev, Amelie Eriksson Karlström, Anna Orlova   +9 more
doaj   +1 more source