Results 51 to 60 of about 6,216 (159)

Penile Metastasis From Castration‐Resistant Prostate Cancer: A Case Report

IJU Case Reports, Volume 9, Issue 5, September 2026.
ABSTRACT Introduction Penile metastasis from prostate cancer—generally associated with a poor prognosis—is rare and underreported. We report one relevant case. Case Presentation The patient was a 65‐year‐old male with metastatic hormone‐sensitive prostate cancer (prostate‐specific antigen [PSA]: 500 ng/mL) and lung, bone, and lymph node metastases. The
Satoshi Asakura, Yoshihiro Nakagami, Tatsuki Inoue, Yuki Matsui, Kazuhiko Oshinomi, Masakazu Nagata, Takashi Fukagai, Yasuyuki Ohira, Yoshiko Yamochi   +8 more
wiley   +1 more source

GRPR-targeting radiotheranostics for breast cancer management

Frontiers in Medicine, 2023
Breast Cancer (BC) is the most common cancer worldwide and, despite the advancements made toward early diagnosis and novel treatments, there is an urgent need to reduce its mortality.
Alice D’Onofrio, Swantje Engelbrecht, Tilman Läppchen, Axel Rominger, Eleni Gourni   +4 more
doaj   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Synthesis, Characterization and In Vitro Evaluation of Hybrid Monomeric Peptides Suited for Multimodal Imaging by PET/OI: Extending the Concept of Charge—Cell Binding Correlation

Pharmaceuticals, 2021
In the context of hybrid multimodal imaging agents for gastrin releasing peptide receptor (GRPR) targeting, a correlation between the net charge and the receptor affinity of the agents was recently found.
Marco Maspero, Xia Cheng, Valeska von Kiedrowski, Clelia Dallanoce, Björn Wängler, Ralph Hübner, Carmen Wängler   +6 more
doaj   +1 more source

Real‐World Prognostic Analysis of Clinical Characteristics in Extensive‐Stage Small Cell Lung Cancer: A Nomogram for Survival Prediction in Patients Receiving First‐Line Immunochemotherapy With Serplulimab

Cancer Medicine, Volume 15, Issue 8, August 2026.
Among 239 patients reviewed, 109 patients with extensive‐stage small‐cell lung cancer receiving first‐line serplulimab‐based immunochemotherapy were included. A nomogram incorporating liver metastasis, maintenance therapy, albumin, and neutrophil‐to‐lymphocyte ratio predicted overall survival and significantly stratified patients into three risk groups
Ying Zhu, Zhongwen Li, Ming Zhang, Yuyun Lan, Yarong Wang, Yao Liu, Yibing Liu   +6 more
wiley   +1 more source

Precision Theranostics in Nuclear Medicine Targeting Gastrin-Releasing Peptide Receptor

Xiehe Yixue Zazhi
The gastrin-releasing peptide receptor (GRPR) is highly expressed in various malignant tumors (e.g., glioblastoma, prostate cancer, and breast cancer) and has emerged as an important molecular target for precision cancer diagnosis and therapy.
WANG Rongxi, ZHU Zhaohui, CHEN Xiaoyuan
doaj   +1 more source

PESIN Conjugates for Multimodal Imaging: Can Multimerization Compensate Charge Influences on Cell Binding Properties? A Case Study

Pharmaceuticals, 2021
Recently, anionic charges were found to negatively influence the in vitro gastrin-releasing peptide receptor (GRPR) binding parameters of dually radioisotope and fluorescent dye labeled GRPR-specific peptide dimers.
Ralph Hübner, Alexa Paretzki, Valeska von Kiedrowski, Marco Maspero, Xia Cheng, Güllü Davarci, Diana Braun, Helen Damerow, Benedikt Judmann, Vasileios Filippou, Clelia Dallanoce, Ralf Schirrmacher, Björn Wängler, Carmen Wängler   +13 more
doaj   +1 more source

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković, Strahinja Pešić, Marija Novaković, Anđela Dubroja Krstić, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Evolution of the Jawed Vertebrate (Gnathostomata) Stomach Through Gene Repertoire Loss: Findings from Agastric Species

Journal of Developmental Biology
The stomach has been a highly conserved organ throughout vertebrate evolution; however, there are now over 20 lineages composed of monotremes, lungfish and teleost fish displaying a secondary loss of stomach function and morphology.
Jackson Dann, Frank Grützner
doaj   +1 more source

AM-37 and ST-36 Are Small Molecule Bombesin Receptor Antagonists

Frontiers in Endocrinology, 2017
While peptide antagonists for the gastrin-releasing peptide receptor (BB2R), neuromedin B receptor (BB1R), and bombesin (BB) receptor subtype-3 (BRS-3) exist, there is a need to develop non-peptide small molecule inhibitors for all three BBR.
Terry W. Moody, Nicole Tashakkori, Samuel A. Mantey, Paola Moreno, Irene Ramos-Alvarez, Marcello Leopoldo, Robert T. Jensen   +6 more
doaj   +1 more source