Results 71 to 80 of about 6,216 (159)

Atypical Behavior in a Typical Carcinoid: When Minimal Proliferation Meets Lympho‐Vascular Invasion—A Case Report

Thoracic Cancer, Volume 17, Issue 14, July 2026.
Left: A 46‐year‐old non‐smoking female with a 2.4 cm right hilar mass (cT1cN0M0). Middle: Postoperative pathology reveals discordance between low proliferation (Ki‐67 < 2%) and unexpected focal lympho‐vascular invasion, with concomitant granulomatous inflammation. Right: After VATS lobectomy (pN0) and active surveillance, no recurrence occurred over 20 
Qilian Wang, Xi Chen, Sicheng Zhou, Guowei Che   +3 more
wiley   +1 more source

Targeting the gastrin-releasing peptide receptor pathway to treat cognitive dysfunction associated with Alzheimer's Disease

Dementia & Neuropsychologia
Increasing evidence indicates that bombesin (BB)-like peptides (BLPs), such as the gastrin-releasing peptide (GRP) and its receptor (GRPR), might play a role in neurological and psychiatric disorders.
Rafael Roesler, Tatiana Luft, Gilberto Schwartsmann   +2 more
doaj   +1 more source

Localization of ^99mTc-GRP Analogs in GRPR-Expressing Tumors: Effects of Peptide Length and Neprilysin Inhibition on Biological Responses

Pharmaceuticals, 2019
The overexpression of gastrin-releasing peptide receptors (GRPRs) in frequently occurring human tumors has provided the opportunity to use bombesin (BBN) analogs as radionuclide carriers to cancer sites for diagnostic and therapeutic purposes.
Aikaterini Kaloudi, Emmanouil Lymperis, Panagiotis Kanellopoulos, Beatrice Waser, Marion de Jong, Eric P. Krenning, Jean Claude Reubi, Berthold A. Nock, Theodosia Maina   +8 more
doaj   +1 more source

Emerging agents for boron neutron capture therapy: Biomolecular carriers paving the way for precision radiotherapy

Precision Radiation Oncology, Volume 10, Issue 2, Page 254-264, June 2026.
Boron neutron capture therapy (BNCT) requires key non‐negotiable technical criteria: megadose administration, precise tumor‐specific targeting, favorable biocompatibility, and sustained tumor retention. Overcoming these interconnected challenges fundamentally depends on biomolecular carriers, which are critical for translating the therapeutic potential
Chang Chen, Maosong Yang, Jiheng Wang, Ling Zhang, Shaobo Huang, Xiao Xu, Yang Liu   +6 more
wiley   +1 more source

The Duodenal Mucosa Plays a Key Role in Metabolic Regulation: Emerging Physiology and New Opportunities for Cell‐Directed and Barrier‐Related Interventions for the Treatment of Diabetes and Obesity

Diabetes, Obesity and Metabolism, Volume 28, Issue S3, Page 3-15, June 2026.
ABSTRACT The duodenum has historically been regarded as a passive digestive conduit for nutrient transit and absorption. However, emerging experimental and clinical evidence supports a revision of this view. In a contemporary model, the proximal small intestine also has roles as a metabolic sensor and endocrine signalling hub that exerts a powerful ...
David A. D’Alessio, Jonathan E. Campbell   +1 more
wiley   +1 more source

Neuroendocrine tumours through an epigenetic lens: Emerging insights for diagnosis and treatment

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Neuroendocrine tumours (NETs) are well‐differentiated epithelial neuroendocrine neoplasms that frequently develop in the small intestine, pancreas, and lungs. NETs originate from neuroendocrine cells specialized in hormone secretion implicated in a number of physiological processes.
Victoria Jacquot, Benjamin Chevalier, Thomas Walter, Benjamin Gibert, Maria Ouzounova   +4 more
wiley   +1 more source

GRPR-induced FAM135A expression promote perineural invasion in prostate cancer

Molecular Cancer
Perineural invasion (PNI) is an independent adverse prognostic marker for prostate cancer (PCa) metastasis. Gastrin releasing peptide receptor (GRPR) targeted imaging and therapeutics have entered clinical trials, while its role in PCa perineural ...
Ning Zhang, Xiaohao Ruan, Siteng Chen, Ruofan Shi, Xiaoqun Yang, Yongle Zhan, Stacia Chun, Chi Yao, Salida Ali, Brian Sze-Ho Ho, Ada Tsui-Lin Ng, Richard KY Lo, Rong Na   +12 more
doaj   +1 more source

Molecular characterization of CCKR in Ctenopharyngodon idella and its involvement in the intestinal immune response to bacterial challenges

Journal of the World Aquaculture Society, Volume 57, Issue 3, June 2026.
Abstract Cholecystokinin receptor (CCKR), an important recognition receptor for the gastrointestinal hormone cholecystokinin (CCK) in the endocrine system, plays a crucial role in regulating immune responses in mammals. In this study, a novel cholecystokinin receptor (CiCCKR) was identified from the grass carp Ctenopharyngodon idella.
Ran Peng, Jingjing Yang, Huilan Mo, Miao Zhang, Xin Li, Xia Zhang, Meixing Guo, Kelan Jin, Fufa Qu, Jianzhong Li, Yunyun Zeng, Xixun Zhou, Zhuangwen Mao, Zhen Liu, Jianzhou Tang   +14 more
wiley   +1 more source

Photocaged Oxytocin and Vasopressin Probes to Decipher Neuropeptide Signalling With High Spatiotemporal Resolution

Angewandte Chemie International Edition, Volume 65, Issue 22, 25 May 2026.
Novel and biocompatible photoactivatable oxytocin and vasopressin probes, utilising state‐of‐the‐art photocages, remain inactive in the dark. Light exposure facilitates rapid spatiotemporal receptor activation and phospholipase C (PLC)‐mediated downstream signalling. Figure created in https://BioRender.com.
Konstantin Raabe, Predrag Kalaba, Xuan Ling Hilary Yong, Greta Crudeli, Sarah Melzer, Erik Keimpema, Victor Anggono, Markus Muttenthaler   +7 more
wiley   +1 more source

In vitro gastrin-releasing peptide response in chicken ovarian follicles

Poultry Science
The gastrin-releasing peptide (GRP) is reported to be mainly produced by the pituitary in chickens, with its receptor (GRPR) highly expressed in the ovaries, indicating its regulatory role in ovarian function. Present study aims to verify the role of GRP
Chunheng Mo, Can Lv, Guoqiang Zhu, Jiannan Zhang, Yuanyou Li, Yajun Wang, Juan Li   +6 more
doaj   +1 more source