Results 61 to 70 of about 6,216 (159)

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Targeting rectal cancer using fluorescent nanoparticles conjugated to a novel GRPR-Binding peptide for tumor imaging applications

Materials & Design
Surgical treatment of rectal cancer is difficult due to anatomical complexity. To improve tumor resection, fluorescence-guided surgery (FGS) has been developed using near-infrared fluorescence (NIRF, approximately 800 nm) and a dedicated camera system ...
Somayeh Rezaei, Mark Fonteyne, Luis J. Cruz, Nada Badr, Ajinkya Manelkar, Mahin Saberi, Ronald L.P. van Vlierberghe, Alexander L. Vahrmeijer, Christina Eich, Fernando Albericio, Louise. van der Weerd, Peter J.K. Kuppen   +11 more
doaj   +1 more source

Effect of Chewing Gum on Bowel Function Recovery in Elderly Patients Following Posterior Lumbar Fusion Surgery: A Randomized Controlled Trial

Orthopaedic Surgery, Volume 18, Issue 8, Page 1641-1648, August 2026.
Chewing gum did not improve early bowel recovery after lumbar fusion. ABSTRACT Objective Given the paucity of prospective randomized evidence on chewing gum for postoperative bowel recovery in elderly spinal fusion patients, this study aimed to assess the efficacy of chewing gum in improving bowel function recovery in the elderly after posterior lumbar
Fuze Liu, Yifei Li, Gaoyang Li, Xiaoyan He, Lin Zhang, Meijia Zhang, Tian Liu, Ying Jiang, Qinlu Wang, Yaping Chen, Hai Wang   +10 more
wiley   +1 more source

Supraspinal Circuit Mechanisms Underlying Itch Processing

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Peripheral pruriceptive signals ascend from the spinal cord to the brainstem, thalamus, and cortex to encode the sensory features of itch. Parallel projections to limbic and basal ganglia circuits mediate affective and motivational components, including aversion and scratching urge.
Yuncheng Luo, Hao‐Di Tang, Ping Liao, Ruotian Jiang   +3 more
wiley   +1 more source

Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord

Nature Communications
Itch is a common side effect of opioid analgesics. The specific neurons mediating opioid-induced itch are still debated, and the mechanistic neuronal circuits remain elusive.
Qian Zeng, Yitong Li, Yifei Wu, Jiawei Wu, Kangtai Xu, Yiming Chen, Yunfei Rao, Nan Li, Yuhui Luo, Changyu Jiang, Chaoran Wu, Zilong Wang   +11 more
doaj   +1 more source

Diurnal regulation of the gastrin‐releasing peptide receptor in the mouse circadian clock [PDF]

European Journal of Neuroscience, 2006
AbstractIn mammals, circadian rhythms are generated by the suprachiasmatic nuclei (SCN) of the hypothalamus. SCN neurons are heterogeneous and can be classified according to their function, anatomical connections, morphology and/or peptidergic identity.
Karatsoreos, Ilia N, Romeo, Russell D, McEwen, Bruce S, Silver, Rae   +3 more
openaire   +3 more sources

Neuroendocrine Transformation Without PSA Elevation in High‐Risk Metastatic Castration‐Sensitive Prostate Cancer Under Androgen Receptor Signaling Inhibition: A Case Report

IJU Case Reports, Volume 9, Issue 4, July 2026.
ABSTRACT Introduction Neuroendocrine prostate cancer is a rare and highly aggressive variant of prostate cancer with a poor prognosis. We report a case in which metastatic castration‐sensitive prostate cancer directly transformed into neuroendocrine prostate cancer without a corresponding increase in prostate‐specific antigen.
Yoshihiro Nakagami, Shintaro Ohnuma, Masashi Tamaoka, Tatsuki Inoue, Motoki Yamagishi, Kazuhiko Oshinomi, Masakazu Nagata, Yasuyuki Oohira, Toshiko Yamochi, Takashi Fukagai   +9 more
wiley   +1 more source

Radiation‐Associated Enteric‐Type Urethral Adenocarcinoma 20 Years After Prostate Brachytherapy: A Case Treated With Neoadjuvant Gemcitabine‐Cisplatin and Robot‐Assisted Radical Cystectomy

IJU Case Reports, Volume 9, Issue 4, July 2026.
ABSTRACT Introduction Brachytherapy is a widely accepted treatment for prostate cancer, in which subsequent radiation‐associated enteric‐type urethral adenocarcinoma is extremely rare. Case Presentation An 83‐year‐old man with a history of cholecystitis, appendicitis, and hyperlipidemia who had undergone brachytherapy 20 years earlier presented with ...
Yuki Tanaka, Yui Fujimura, Koya Morishita, Yuta Kashiwagi, Satoshi Katsuno, Tatsuya Nagai, Yuki Okumura   +6 more
wiley   +1 more source

Initial Dose Tarlatamab–Associated Tumour Lysis Syndrome in Small Cell Lung Cancer: A Case Report

Respirology Case Reports, Volume 14, Issue 7, July 2026.
We report a fatal case of acute TLS following a single 1‐mg dose of tarlatamab in a patient with relapsed SCLC with extensive liver metastases. This case highlights the importance of TLS risk assessment prior to tarlatamab treatment. Extensive liver metastases and elevated lactate dehydrogenase levels may be risk factors for TLS in patients with SCLC ...
Katsuhiko Shibata, Hiromu Tanaka, Yusuke Arai, Yusuke Watanuki, Takashi Kokubo, Yo Watanabe, Shingo Nakayama, Takahiro Asami, Takashi Inoue   +8 more
wiley   +1 more source

Critical evaluation of the expression of gastrin-releasing peptide in dorsal root ganglia and spinal cord

Molecular Pain, 2016
There are substantial disagreements about the expression of gastrin-releasing peptide (GRP) in sensory neurons and whether GRP antibody cross-reacts with substance P (SP).
Devin M Barry PhD, Hui Li PhD, Xian-Yu Liu PhD, Kai-Feng Shen PhD, Xue-Ting Liu PhD, Zhen-Yu Wu, Admire Munanairi PhD, Xiao-Jun Chen, Jun Yin, Yan-Gang Sun PhD, Yun-Qing Li PhD, Zhou-Feng Chen PhD   +11 more
doaj   +1 more source