Results 131 to 140 of about 18,138 (288)

Resveratrol attenuates areca nut extract‐induced chronic colitis by suppressing pyroptosis of intestinal epithelial cells via modulating cGAS/STING signaling

VIEW, EarlyView.
Areca nut extract (ANE), commonly consumed in some cultures, can damage gut cells by triggering inflammation and cell death through a pathway called cGAS‐STING. This leads to the release of harmful inflammatory substances and weakens the gut barrier. Our study shows that resveratrol, a natural compound found in foods like grapes, can block this harmful
Jing Zhang, Muhammad Tufail, Yu‐Qi Huang, Can‐Hua Jiang, Ning Li   +4 more
wiley   +1 more source

Role of Pyroptosis in Endometrial Cancer and Its Therapeutic Regulation

Journal of Inflammation Research
Abdullah Al Mamun,1,2 Peiwu Geng,1 Shuanghu Wang,1 Chuxiao Shao1 1Key Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui, The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of ...
Al Mamun A, Geng P, Wang S, Shao C
doaj  

Palmitoylation at a conserved cysteine residue facilitates gasdermin D-mediated pyroptosis and cytokine release [PDF]

Gasdermin D (GSDMD)-mediated pyroptotic cell death drives inflammatory cytokine release and downstream immune responses upon inflammasome activation, which play important roles in host defense and inflammatory disorders. Upon activation by proteases, the
Bracey, Syrena, Dickinson, Bryan C., Lan, Tong, Li, Ling, Li, Sai, Liu, Zhonghua, Miyagi, Masaru, Osme, Abdullah, Pizarro, Theresa T., Vidmar, Kaylynn, Wang, Chuanping, Willard, Belinda, Xiao, Tsan Sam   +12 more
core   +1 more source

Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation. [PDF]

, 2019
Apoptosis can promote inflammation by triggering activation of the NLRP3 inflammasome (NLR family, pyrin domain containing 3). However, the molecular mechanisms regulating these processes are ill-defined.
Broz, P., Chen, K.W., Demarco, B.
core   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Staphylococcus Aureus Membrane Vesicles Kill Tumor Cells Through a Caspase-1-Dependent Pyroptosis Pathway

International Journal of Nanomedicine
Mengyang Li,1,* Yuting Wang,2,* He Liu,2 Xiaonan Huang,2 Huagang Peng,2 Yi Yang,2 Zhen Hu,2 Jianxiong Dou,2 Chuan Xiao,2 Juan Chen,3 Weilong Shang,2 Xiancai Rao1,2 1Department of Microbiology, School of Medicine, Chongqing University, Chongqing ...
Li M, Wang Y, Liu H, Huang X, Peng H, Yang Y, Hu Z, Dou J, Xiao C, Chen J, Shang W, Rao X   +11 more
doaj  

Maternal age effects on myometrial expression of contractile proteins, uterine gene expression, and contractile activity during labor in the rat [PDF]

, 2015
Advanced maternal age of first time pregnant mothers is associated with prolonged and dysfunctional labor and significant risk of emergency cesarean section.
Agarwal, Agostinis, Allen, Andersson, Arai, Arend, Ares, Arrowsmith, Arsenov, Aussel, Babiychuk, Bakircioglu, Bell, Bots, Braciale, Brasier, Brckalo, Brigelius-Flohé, Brown, Bréart, Castrillo, Challis, Chan, Chapple, Chevillard, Cluff, Coutinho, Dong, Doring, Drab, Duffy, Ebisch, Eckstrum, Elce, Elliot, Elmes, Elovitz, Friel, Gardner, Garreau, Gerlo, Gil, Gomez-Lopez, Greenberg, Gross, Grossman, Guihard, Haddad, Hamilton, Hemmerich, Heng, Hung, Joseph, Joseph, Keirse, Kim, King, Klukovits, Kozinszky, Larsen, Ledingham, Lee, Leung, Lopez Bernal, Luke, Luu-The, Ly, Lye, Lye, Main, Malmström, Martin, Matthews, McGinn, McNally, Milligan, Mittal, Montan, Morgan, Morrison, Nie, Noble, Norman, O'Connor, Ogawa, Okamoto, Osman, Paganini, Paik, Park, Payne, Pennefather, Phillips, Quaas, Ramkhelawon, Richeri, Riley, Roberts, Romero, Schellenberg, Schlegel, Schousboe, Schutzer, Scott, Sengupta, Sennstrom, Shaul, Shiratori, Simon, Singh, Smith, Smith, Somara, Stepan, Sugino, Sykes, Tadagavadi, Tato, Telfer, Temma-Asano, Thomson, Toescu, Vassalli, Ventura, Wang, Wathes, Wathes, Willecke, Winkler, Yahata, Yellon, Young, Yuan, Zante, Zhang, Zhao, Zhu, Zoubina, Zuo   +138 more
core   +2 more sources

Therapeutic Efficacy of the Supersulfide Donor NAC‐S2 in Influenza Virus Pneumonia via Suppression of Excessive Inflammatory Responses

Microbiology and Immunology, EarlyView.
ABSTRACT Influenza pneumonia is characterized by excessive inflammatory responses that contribute to severe lung injury and mortality. Supersulfides, endogenously produced cysteine‐derived persulfides and polysulfides, exert potent antioxidant, anti‐ferroptotic, and anti‐inflammatory activities; however, their therapeutic potential after disease onset ...
Foysal Hossen, Takahisa Kouwaki, Yukio Fujiwara, Hiroyasu Tsutsuki, Tianli Zhang, Chunyu Guo, Azizur Rahman, Yoshihiro Komohara, Hiroyuki Oshiumi, Tomohiro Sawa   +9 more
wiley   +1 more source

Sacubitril/Valsartan Attenuates Inflammation and Fibrosis Associated With Decreased Integrin α8 and Inhibits Hepatocarcinogenesis in a Rat Model of Metabolic Dysfunction‐Associated Steatohepatitis

Hepatology Research, EarlyView.
Sacubitril/Valsartan (Sac/Val) alleviates fibrosis and inflammation in metabolic dysfunction‐associated steatohepatitis (MASH). Its anti‐fibrotic effect is linked to the suppression of Integrin alpha 8 (Itga8), a protein crucial for hepatic stellate cell (HSC) activation and collagen production.
Hayato Kawamura, Aya Naiki‐Ito, Xiaochen Kuang, Akihiro Murakami, Masayuki Komura, Takanori Suzuki, Hiroyuki Kato, Yuko Nagayasu, Kentaro Matsuura, Kei Fujiwara, Hiromi Kataoka, Satoru Takahashi   +11 more
wiley   +1 more source

ALIX mediates reversible gasdermin-D pore formation via the endosomal pathway to limit pyroptosis by active membrane repair

Cell Death and Disease
Pyroptosis is a form of regulatory cell death characterized by membrane rupture and release of pro-inflammatory signals. In pyroptosis, Caspase-1 activation leads to the cleavage of gasdermin-D (GSDMD).
Sylvia Otchere, Prafulla Shrestha, Himesh N. Parmar, Jadyn F. Perry, Brittany L. Hofmeister, Michelle Steyn, Radhey S. Kaushik, Adam D. Hoppe, Natalie W. Thiex, Ryan L. Hanson, Jaime Lopez-Mosqueda, Gergely Imre   +11 more
doaj   +1 more source