Results 121 to 130 of about 14,672 (225)

SIRT2 Promotes NLRP3-Mediated Microglia Pyroptosis and Neuroinflammation via FOXO3a Pathway After Subarachnoid Hemorrhage

Journal of Inflammation Research
Jia-Qing Sun,1,5,* Bin Sheng,2,5,* Sen Gao,2,5,* Xun-Zhi Liu,2,5 Yue Cui,4,5 Zheng Peng,2,5 Xiang-Xin Chen,2,5 Peng-Fei Ding,3,5 Zong Zhuang,2,5 Ling-Yun Wu,2,5 Chun-Hua Hang,1– 5 Wei Li2– 5 1Department of Neurosurgery, Nanjing Drum Tower ...
Sun JQ, Sheng B, Gao S, Liu XZ, Cui Y, Peng Z, Chen XX, Ding PF, Zhuang Z, Wu LY, Hang CH, Li W   +11 more
doaj  

Recent Advances in Fluorescent Probes for Imaging Enzyme Activity in NETosis

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
Fluorescent probes enable real‐time visualization of neutrophil effector functions. This review summarizes current probe design strategies and emerging tools for imaging key enzymatic activities, with emphasis on mechanisms underlying NETosis, a lytic form of neutrophil extracellular trap (NET) formation. We discuss current limitations, challenges, and
Enebie Ramos Cáceres, Marijn J. Hollander, Kimberly M. Bonger   +2 more
wiley   +1 more source

The Mechanism of Pyroptosis and Its Application Prospect in Diabetic Wound Healing

Journal of Inflammation Research
Abdullah Al Mamun,1,2 Chuxiao Shao,1 Peiwu Geng,1 Shuanghu Wang,1 Jian Xiao2,3 1Central Laboratory of the Sixth Affiliated Hospital of Wenzhou Medical University, Lishui People’s Hospital, Lishui City, Zhejiang, 323000, People’s Republic of China ...
Al Mamun A, Shao C, Geng P, Wang S, Xiao J   +4 more
doaj  

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

IL-17RA Promotes Cigarette Smoke-Induced Alveolar Epithelial Cell Pyroptosis in COPD via Dual Activation of the NLRP3/Caspase1/GSDMD and NF-κB/GSDME Pathways. [PDF]

J Inflamm Res
An X, Gu Y, Zhou J, Liu Y, Yu S, Zhang L, Ouyang Y.   +6 more
europepmc   +1 more source

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong, Zhen Wang, Xiaoxiao Lin, Ziwen Lei, Qianqian Huang, Hang Liu, Fei Luan, Junbo Zou, Yajun Shi   +8 more
wiley   +1 more source

A CD4+ T lymphocyte–specific TCR/GSDMD/IL-2 axis facilitates antitumor immunity

The Journal of Clinical Investigation
Gasdermin (GSDM) family proteins mediate tumor pyroptosis and impact cancer progression, but other than that, their involvement in the tumor immune microenvironment remains largely unknown.
Yihan Yao, Lingling Wang, Weiqin Jiang, Ning Wang, Mengjie Li, Wenlong Lin, Ting Zhang, Wanqiang Sheng, Xiaojian Wang   +8 more
doaj   +1 more source

Upregulation of NFS1 and downregulation of GSDMD as prognostic biomarkers in acute myeloid leukemia: implications for diagnosis and therapeutic strategies. [PDF]

BMC Cancer
Radwan SM, Mostafa D, Radwan RA, Elghobary HA, Elghamry WR, Kamal AM.   +5 more
europepmc   +1 more source

GSDMD is dispensable for hematopoietic homeostasis and hematopoietic stem cell function

Life Medicine, 2022
Cong, Tingting, Wang, Yuqian, Wang, Jianwei   +2 more
openaire   +2 more sources

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source