Results 101 to 110 of about 14,672 (225)

The Neglected Role of GSDMD C‐Terminal in Counteracting Type I Interferon Signaling

Advanced Science
The GSDMD N‐terminal fragment (GSDMD‐NT)‐mediated pyroptosis is extensively investigated. However, the role of the C‐terminal domain of GSDMD (GSDMD‐CT) is unexplored. This study demonstrates that GSDMD‐CT acts as a negative regulator that suppresses IFN‐
Weilv Xu, Suhui He, Wen Shi, Jinxia Xu, Shiyang Liu, Zexu Yu, Danyue Li, Qiao Jin, Yumeng Wang, Zian Zhang, Qian Lv, Yuanxiang Ge, Yunjie Li, Xinyue Li, Nan Chen, Xinyu Fu, Yang Yang, Fushan Shi   +17 more
doaj   +1 more source

Photo‐responsive carbon dots for pyroptosis‐mediated anti‐tumor application

Responsive Materials, EarlyView.
Photo‐responsive CDs generate ROS to induce tumor cell pyroptosis, thereby stimulating antitumor immunity. Abstract Pyroptosis refers to a kind of lytic programmed cell death, characterized by the release of pro‐inflammatory cytokines during the process. Owing to its immune response stimulation ability, pyroptosis has garnered considerable attention in
Lingyun Li, Xue Wu, Zekun Yan, Jun Wu, Caishi Huang, Songnan Qu   +5 more
wiley   +1 more source

Photoactivated iridium(III) complexes drive pyroptosis–necroptosis synergy for multi‐network photoimmunotherapy of renal cell carcinoma

Smart Molecules, EarlyView.
Photoactivated iridium(III) complexes trigger mitochondrial DNA leakage and Ca²⁺ efflux, simultaneously driving pyroptosis and necroptosis to synergistically enhance immunogenic cell death. This multi‐network cascade promotes dendritic cell maturation and CD8⁺ T cell activation, achieving potent photoimmunotherapy of renal cell carcinoma.
Xin Qin, Meng‐Di Chen, Wenqi Gao, Yiping Wang, Lin‐Qing Liu, Zhen Teng, Tienan Qi, Qiyuan Wang, Yuxuan Wang, Daoxiang Li, Keqiang Yan, Ling Pan, Zhongwei Zhao, Shuo Zhao, Kang‐Nan Wang, Shuai Fu, Nengwang Yu   +16 more
wiley   +1 more source

ALIX mediates reversible gasdermin-D pore formation via the endosomal pathway to limit pyroptosis by active membrane repair

Cell Death and Disease
Pyroptosis is a form of regulatory cell death characterized by membrane rupture and release of pro-inflammatory signals. In pyroptosis, Caspase-1 activation leads to the cleavage of gasdermin-D (GSDMD).
Sylvia Otchere, Prafulla Shrestha, Himesh N. Parmar, Jadyn F. Perry, Brittany L. Hofmeister, Michelle Steyn, Radhey S. Kaushik, Adam D. Hoppe, Natalie W. Thiex, Ryan L. Hanson, Jaime Lopez-Mosqueda, Gergely Imre   +11 more
doaj   +1 more source

Role of gasdermin D in inflammatory diseases: from mechanism to therapeutics

Frontiers in Immunology
Inflammatory diseases compromise a clinically common and diverse group of conditions, causing detrimental effects on body functions. Gasdermins (GSDM) are pore-forming proteins, playing pivotal roles in modulating inflammation.
Chak Kwong Cheng, Min Yi, Min Yi, Li Wang, Yu Huang   +4 more
doaj   +1 more source

Comments to the “Letter to the Editor” for the manuscript titled “Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease”

Brain Pathology, EarlyView.
Beta amyloid diffuse plaques, neurofibrillary tangles and neuritic plaques, are increased in densities at the intermediate stage of Alzheimer's neuropathological change. These pathological changes releasing Pathogen‐Associated Molecular Patterns (PAMPs) and Damage‐Associated Molecular Patterns (DAMPs).
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

Exosomes from IH- Induced bEnd3 Cells Promote OSA Cognitive Impairment via miR-20a-5p/MFN2 Mediated Pyroptosis of HT22 Cells

Nature and Science of Sleep
Zhifeng Chen,1– 4 Yulin Shang,5 Yanru Ou,1– 4 Li Zhou,1– 4 Ting Liu,1– 4 Subo Gong,6 Xudong Xiang,7 Yating Peng,1– 4 Ruoyun Ouyang1– 4 1Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha ...
Chen Z, Shang Y, Ou Y, Zhou L, Liu T, Gong S, Xiang X, Peng Y, Ouyang R   +8 more
doaj  

Feiwei Heji Enhances Antitumor Immunity by MLL4‐Dependent Regulation of Pyroptosis in Lung Cancer

Cancer Science, EarlyView.
Feiwei Heji suppresses lung tumor growth by downregulating MLL4 and activating caspase‐1/GSDMD‐associated pyroptosis. This pyroptosis‐related inflammatory response enhances CD8+ T‐cell‐mediated antitumor immunity, revealing an MLL4‐pyroptosis‐immune axis underlying the therapeutic activity of Feiwei Heji.
Nan Cheng, Ruoyu Jiang, Wei Li, Wenjie Huang, Qiao Peng, Tong Zhao, Chufeng Zhang   +6 more
wiley   +1 more source

Pyroptosis in Osteoarthritis: Molecular Mechanisms and Therapeutic Implications

Journal of Inflammation Research
Yeping Chen,1,* Daofu Zeng,1,* Guizheng Wei,1,* Zhidong Liao,1,2 Rongyuan Liang,1 Xiajie Huang,1,2 William W Lu,3 Yan Chen1,2 1Department of Bone and Joint Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi,
Chen Y, Zeng D, Wei G, Liao Z, Liang R, Huang X, Lu WW, Chen Y   +7 more
doaj  

Deletion of gasdermin D promotes granulocytic myeloid-derived suppressor cell differentiation by decreased release of mitochondrial DNA to promote tumor escape

Cancer Immunology, Immunotherapy
Gasdermin D (GSDMD), an effector molecule of cell pyroptosis, is known to be activated in various cells during inflammation. However, the patterns of GSDMD activation in immune regulatory cells such as myeloid-derived suppressor cells (MDSCs) remain ...
Min Gu, Weiwei Chen, Shizhen Ding, Zhijie Lin, Li Qian, Weiming Xiao, Xiaoqin Jia, Guotao Lu, Weijuan Gong   +8 more
doaj   +1 more source