Results 81 to 90 of about 17,882 (284)

RING1 dictates GSDMD-mediated inflammatory response and host susceptibility to pathogen infection

RING1 is an E3 ligase component of the polycomb repressive complex 1 (PRC1) with known roles in chromatin regulation and cellular processes such as apoptosis and autophagy. However, its involvement in inflammation and pyroptosis remains elusive. Here, we
Li, Jixi, Li, Suhua, Li, Yuanyuan, Idris, Adi, Geng, Lu, Deng, Yifan, Ge, Baoxue, Gao, Wenqing, Pan, Jiasong, Qiu, Yuxin, Shen, Yajie, Fan, Xiaoyong, Hu, Zhidong, Chen, Xiangjun, Guo, Qingqing, Huang, Jinqing, Yang, Hua, Liu, Shanshan, Liu, Xuehe, https://orcid.org/, et al.   +20 more
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DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Change in Gasdermin-D gene expression in familial Mediterranean fever compared to healthy children with or without acute infections

The Turkish Journal of Pediatrics
Background. Gasdermin-D (GSDMD) is an inflammasome regulator. Pyroptosis and GSDMD-mediated interleukin (IL)-1β secretion abolish in GSDMD-deficient familial Mediterranean fever (FMF) knock-in mice. We aimed to investigate GSDMD gene expression (GSDMD-∆)
Pınar Özge Avar Aydın, İsmail Yaz, Dilan İnan, Zeynep Birsin Özçakar, Sevil Oskay Halaçlı, Deniz Çağdaş   +5 more
doaj   +1 more source

Pyroptosis-Mediator GSDMD in Plasma: A Promising Biomarker for Early Diagnosis of Type 2 Diabetes [PDF]

Lijing Huo,1,2 Xuexin Liu,2 Nan Ding,2 Hairui Zhang,1 Shiyu Hou,1 Jintian He,1 Baohua Zhao1 1College of Life Science, Hebei Normal University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Medical Laboratory, Hebei General Hospital ...
Liu X, Huo L, He J, Zhao B, Zhang H, Ding N, Hou S   +6 more
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GSDMD deficiency prevents damage to multiple tissues in NOMID mice.

, 2018
Representative images of liver, skin, and spleen from 3-week-old WT mice (3 males and 1 female), NOMID mice (3 males and 1 female), NOMID;Gsdmd−/− mice (2 males) and Gsdmd−/− mice (3 males and 1 female) stained with HE.
Roberto Civitelli (2015), Gabriel Mbalaviele (168987), Chun Wang (337817), Jianqiu Xiao (5924582), Canxin Xu (3847465), Yael Alippe (5924588), Yousef Abu-Amer (320126), Dustin Kress (5924591), Juo-Chin Yao (5924585), Thirumala-Devi Kanneganti (62745), Daniel C. Link (92804)   +10 more
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MOESM8 of Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway

, 2020
Additional file 8. GSDMD shRNA. Identification of GSDMD as a required component for pyroptosis (GSDMD shRNA)
Fang Wu (267711), Ye Yang (297214), Song Chen (69646), Wei Bao (241898), Ping Liu (156158), Ping Zhu (11521)   +5 more
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GSDME rather than GSDMD is cleaved during cell pyroptosis of breast cancer cells induced by 4f.

, 2022
(A, B) Full-length GSDMD (GSDMD-F) and GSDMD-C terminal (GSDMD-C) were detected by western blotting in MCF-7 and MDA-MB-231 cells treated with different doses of 4f.
Zhi Zhou (154130), Wei Yi (321782), Hui Gao (169623), Lei Ma (221178), Mengyao Bian (5390579)   +4 more
core   +1 more source

IFI27 and BAX are Essential for GSDME‐Mediated Myeloma Cell Pyroptosis

Advanced Science, EarlyView.
The proposed model of GSDME‐mediated MM cell pyroptosis modulated by IFI27 and BAX. IFI27 is downregulated in MM cells. Upon pyroptotic stimulation, such as DOX or ETO treatment, IFI27 is induced, therefore liberating BAX from BCL‐2 ❶. BAX is then recruited to mitochondria and forms homo‐oligomeric channels in OMM, therefore leading to cytochrome C ...
Yaoli Cui, Yuening Sun, Ziyang Liu, Xuntao Lai, Yunshu Zhao, Yan'er Wang, Yuanming He, Fang Xu, Du Feng, Longlong Liu, Zhenqian Huang, Lijie Xing, Xinliang Mao   +12 more
wiley   +1 more source

Pyroptosis-Mediator GSDMD in Plasma: A Potent Biomarker Lung Cancer Diagnosis and Prognosis Assessment [PDF]

Xuexin Liu, Fang Yu, Nan Ding, Changmei Wei, Yuhui Cui, Lijing Huo Department of Medical Laboratory, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of ChinaCorrespondence: Lijing Huo, Department of Medical Laboratory, Hebei General ...
Liu X, Huo L, Cui Y, Wei C, Yu F, Ding N
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