Results 111 to 120 of about 13,805 (203)

Role of gasdermin D in inflammatory diseases: from mechanism to therapeutics

Frontiers in Immunology
Inflammatory diseases compromise a clinically common and diverse group of conditions, causing detrimental effects on body functions. Gasdermins (GSDM) are pore-forming proteins, playing pivotal roles in modulating inflammation.
Chak Kwong Cheng, Min Yi, Min Yi, Li Wang, Yu Huang   +4 more
doaj   +1 more source

The Critical Role of GALNTs‐Regulated O‐GalNAc Glycosylation in Cancer Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The GALNT family initiates mucin‐type O‐GalNAc glycosylation in the Golgi apparatus and how regulatory mechanisms, including GALNT relocalization and microRNA control, modulate this process. Dysregulated O‐GalNAc glycosylation alters key cellular behaviors and promotes cancer malignancy, highlighting its relevance to tumor progression as well as its ...
Jiahao Liu, Sihan Wu, Ge Zhang, Jiehan Li, Yuhan Yin, Aman Uiiah, Sanfei Peng, Yang Fu   +7 more
wiley   +1 more source

Exosomes from IH- Induced bEnd3 Cells Promote OSA Cognitive Impairment via miR-20a-5p/MFN2 Mediated Pyroptosis of HT22 Cells

Nature and Science of Sleep
Zhifeng Chen,1– 4 Yulin Shang,5 Yanru Ou,1– 4 Li Zhou,1– 4 Ting Liu,1– 4 Subo Gong,6 Xudong Xiang,7 Yating Peng,1– 4 Ruoyun Ouyang1– 4 1Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha ...
Chen Z, Shang Y, Ou Y, Zhou L, Liu T, Gong S, Xiang X, Peng Y, Ouyang R   +8 more
doaj  

Pyroptosis in Osteoarthritis: Molecular Mechanisms and Therapeutic Implications

Journal of Inflammation Research
Yeping Chen,1,* Daofu Zeng,1,* Guizheng Wei,1,* Zhidong Liao,1,2 Rongyuan Liang,1 Xiajie Huang,1,2 William W Lu,3 Yan Chen1,2 1Department of Bone and Joint Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi,
Chen Y, Zeng D, Wei G, Liao Z, Liang R, Huang X, Lu WW, Chen Y   +7 more
doaj  

A CD4+ T lymphocyte–specific TCR/GSDMD/IL-2 axis facilitates antitumor immunity

The Journal of Clinical Investigation
Gasdermin (GSDM) family proteins mediate tumor pyroptosis and impact cancer progression, but other than that, their involvement in the tumor immune microenvironment remains largely unknown.
Yihan Yao, Lingling Wang, Weiqin Jiang, Ning Wang, Mengjie Li, Wenlong Lin, Ting Zhang, Wanqiang Sheng, Xiaojian Wang   +8 more
doaj   +1 more source

Pyroptosis in Diabetic Peripheral Neuropathy and its Therapeutic Regulation

Journal of Inflammation Research
Abdullah Al Mamun,1,2 Chuxiao Shao,1 Peiwu Geng,1 Shuanghu Wang,1 Jian Xiao1– 3 1Central Laboratory of The Lishui Hospital of Wenzhou Medical University, Lishui People’s Hospital, Lishui, Zhejiang, 323000, People’s Republic of China; 2Molecular ...
Al Mamun A, Shao C, Geng P, Wang S, Xiao J   +4 more
doaj  

Chemerin Promotes Oral Squamous Cell Carcinoma Progression via NLRP3-Mediated Pyroptosis and the GSDMD-N Pathway. [PDF]

Int Dent J
Zhang X, Guo Y, Gao F, Ni X, Li T, Wang C, Lin M, Tan X, Wang N, Feng Y.   +9 more
europepmc   +1 more source

Gasdermin as a Molecular Signature and Predictor of Adult-Type Diffuse Glioma Severity and Grading. [PDF]

J Clin Med
Kaczor S, Hubert K, Papuga S, Pawlak D, Harish B, Hermanowicz A, Kowalska M, Hermanowicz JM.   +7 more
europepmc   +1 more source

Targeting pyroptosis to treat aortic aneurysms: From mechanism to drug discovery (Review). [PDF]

Int J Mol Med
Mao J, Luo M, Ruan L, Zhang C.
europepmc   +1 more source

Prognostic value of serum gasdermin D in predicting major adverse cardiovascular events in patients with unstable angina: a prospective observational study. [PDF]

BMC Cardiovasc Disord
Wu L, Zhou Z, Yang X, Wu Q, Tan W.
europepmc   +1 more source