Results 131 to 140 of about 14,672 (225)

Gasdermin D antagonizes immunosuppression in prostate cancer by inducing LAMC2 degradation to block M2 macrophage polarization. [PDF]

J Immunother Cancer
Du Q, Han Z, Zhang Y, Li Y, Sun A, Wang B, Chen Y, Wang X.   +7 more
europepmc   +1 more source

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, Volume 26, Issue 8, Page 29-40, August 2026.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source

Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis. [PDF]

Mol Med Rep
Ding S, Yang H, Lu T, Luo Y, Xu L, Zeng X.   +5 more
europepmc   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, Volume 117, Issue 8, Page 2064-2084, August 2026.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Disulfiram Attenuates Bleomycin-Induced Lung Inflammation and Fibrosis with Reduced Endothelial Pyroptosis and Neutrophil Adhesion. [PDF]

J Inflamm Res
Sun CY, Yang WL, Shen HC, Yu WK, Chen WC, Yang KY.   +5 more
europepmc   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

ANGPT1-GABARAP axis modulates NLRP3 inflammasome-mediated pyroptosis in Crohn's disease. [PDF]

Front Immunol
Li Y, He J, Gao P, Fu Z, Guo Y, Gao H, Li C, Zhang X.   +7 more
europepmc   +1 more source

Inhibiting HIF‐1α‐Induced miR‐663b Improves Pulmonary Arterial Hypertension by Reducing Dysfunctions of PASMCs Through Repressing Sirt1‐ZBP1‐Mediated PANoptosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Pulmonary arterial hypertension (PAH) is a progressive disease characterised by vascular remodelling. Inflammatory responses and oxidative stress have been shown to contribute to its progression. This study investigated the effects of a novel HIF‐1α‐miR‐663b axis on pulmonary arterial smooth muscle inflammation, oxidative stress and apoptosis ...
Le Shen, Honghong Ma, Yang Yu, Yan Xu, Qun Yuan, Xia Zhao, Bing Zhuan   +6 more
wiley   +1 more source

Salmonella Effector SpvC Targets SEC23B of Intestinal Epithelial Cells to Resist Gasdermin D-Mediated Protection Against Systemic Infection. [PDF]

Microorganisms
Zhou L, Yang Y, Kang L, You J, Wang Y, Xu A, Tu G, Huang R, Zhou Z, Li M, Wu S.   +10 more
europepmc   +1 more source

A GSDMD agonist boosts specific antitumor immunity

Cell Research
Yingying Zhang, Jiahuai Han
openaire   +3 more sources