Results 141 to 150 of about 18,138 (288)
CD73 alleviates GSDMD‐mediated microglia pyroptosis in spinal cord injury through PI3K/AKT/Foxo1 signaling [PDF]
, 2020 Shun Xu +12 more
openalex +1 more source
Immunology, EarlyView.Schematic overview of the roles triggering receptor expressed on myeloid cells‐1 (TREM‐1) plays in monosodium urate (MSU) crystal‐induced inflammasome activation and IL‐1β secretion in gout arthritis. The present study provides novel data suggesting that blockade of TREM‐1 by LP17 attenuates MSU‐crystal‐induced inflammation through inhibition of ...
Yair Molad +2 more
wiley +1 more source
Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis
Journal of Periodontal Research, EarlyView.A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth +5 more
wiley +1 more source
Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury
Experimental Physiology, EarlyView.Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley +1 more source
Nucleic acid sensors and programmed cell death [PDF]
, 2020 Liverpool, Layal +2 more
core +2 more sources
The FASEB Journal, Volume 40, Issue 3, 15 February 2026.Utilizing a clinically relevant course of treatment, our study reveals that glucocorticoids protect against the late NLRP3 inflammasome activation regulating the IL‐1β secretion, the processing of GSDM‐D and pyroptosis following signal 2 stimulation. These potent anti‐inflammatory effects are mediated by the activation of GR signaling and the expansion
David Diaz‐Jimenez +11 more
wiley +1 more source
Advanced Functional Materials, Volume 36, Issue 11, 5 February 2026.FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu +5 more
wiley +1 more source
Targeting of GSDMD sensitizes HCC to anti-PD-1 by activating cGAS pathway and downregulating PD-L1 expression [PDF]
, 2022 Tingting Lv +5 more
openalex +1 more source
Molecular tools and model systems for studying inflammasome activation [PDF]
, 2019 Upon cellular stress or invasion by pathogens such as Mycobacterium tuberculosis (Mtb), inflammasomes are activated as an innate immune response, an important host-defense mechanism to resist pathogens.
Kim, Haelin
core