EZH2–STAT3 signaling pathway regulates GSDMD-mediated pyroptosis in glioblastoma
Cell Death DiscoveryAbstractGlioblastoma multiforme (GBM) is the most therapeutically challenging primary brain tumor owing to the unique physiological structure of the blood–brain barrier. Lately, research on targeted therapy for gliomas has shifted focus toward the tumor microenvironment and local immune responses.
Dong Yu +5 more
openaire +3 more sources
Role of gasdermin D in inflammatory diseases: from mechanism to therapeutics
Frontiers in ImmunologyInflammatory diseases compromise a clinically common and diverse group of conditions, causing detrimental effects on body functions. Gasdermins (GSDM) are pore-forming proteins, playing pivotal roles in modulating inflammation.
Chak Kwong Cheng +4 more
doaj +1 more source
Cell Proliferation, Volume 59, Issue 2, February 2026.Mitochondrial quality control (MQC) impairment plays a central role in driving the pathogenesis of metabolism‐associated steatotic liver disease (MASLD). Specifically, this is manifested as reduced mitophagy; increased mitochondrial fission and decreased fusion; and impaired mitochondrial biogenesis.
Wenkai Fu +8 more
wiley +1 more source
Testosterone‐Induced Pyroptotic Death of Ovarian Granulosa Cells in PCOS Might Involve Both GSDMD and GSDME, the Latter Possibly Enabling a Crosstalk Between Apoptosis and Pyroptosis [PDF]
Caglar Berk
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Experimental Physiology, Volume 111, Issue 2, Page 489-500, 1 February 2026.Abstract Type 2 diabetes mellitus (T2DM) significantly increases the risk and severity of cerebral ischaemia–reperfusion (IR) injury, yet effective neuroprotective treatments for diabetic stroke remain limited. This study explored whether a combination of sinomenine and metformin could offer enhanced neuroprotection in diabetic rats subjected to ...
Wendi Li +2 more
wiley +1 more source
MiR-199a-3p Attenuates Sepsis-Induced Acute Lung Injury by Targeting NLRP1 and Suppressing Caspase-1/GSDMD-Mediated Pyroptosis in a CLP Rat Model [PDF]
Wenhan Xia +4 more
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<p>LPS Enhances the Chemosensitivity of Oxaliplatin in HT29 Cells via GSDMD-Mediated Pyroptosis</p>
, 2020 Li-Sha Wu +12 more
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The FASEB Journal, Volume 40, Issue 1, 15 January 2026.Schematic diagram of the triggering mechanism of necroptosis after cerebral ischemia. First, CCL11 targetedly binds to CCR3 on the surface of astrocytes and upregulates the expression of CCR3. After CCR3 activation, it triggers the transcriptional activation of necroptosis.
Han Yin +10 more
wiley +1 more source
Drug D, a Diosgenin Derive, Inhibits L-Arginine-Induced Acute Pancreatitis through Meditating GSDMD in the Endoplasmic Reticulum via the TXNIP/HIF-1α Pathway [PDF]
, 2022 Cuicui Zhang +13 more
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Butin regulates the NLRP3/CASP-1/GSDMD pyroptosis axis to inhibit proliferation and pyroptosis in human fibroblast-like synoviocytes of rheumatoid arthritis [PDF]
Hao Li +5 more
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