Results 181 to 190 of about 13,805 (203)

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Nature, 2015
Inflammatory caspases (caspase-1, -4, -5 and -11) are critical for innate defences. Caspase-1 is activated by ligands of various canonical inflammasomes, and caspase-4, -5 and -11 directly recognize bacterial lipopolysaccharide, both of which trigger pyroptosis.
Jianjin Shi, Yue Zhao, Kun Wang
exaly   +3 more sources

PIK3CG Regulates NLRP3/GSDMD-Mediated Pyroptosis in Septic Myocardial Injury

Inflammation, 2023
Cardiac insufficiency is a common complication of sepsis with high mortality. Inflammatory programmed cell death (pyroptosis) executed by NLRP3/gasdermin D (GSDMD) is intrinsically correlated with septic myocardial injury. However, it remains unclear whether PIK3CG, a classical target of septic myocardial injury, can affect pyroptosis by regulating ...
Chenxi, Lu, Jie, Liu, Germaine, Escames, Yang, Yang, Xue, Wu, Qiong, Liu, Junmin, Chen, Yanbin, Song, Zheng, Wang, Chao, Deng, Darío, Acuña-Castroviejo, Xue, Wang   +11 more
openaire   +2 more sources

SUMOylation regulates GSDMD stability and pyroptosis

International Immunopharmacology
Various post-translational modifications (PTMs), such as palmitoylation, acetylation, and ubiquitination, have been shown to regulate pyroptosis. However, the role of small ubiquitin-like modifier (SUMO) modification, known as SUMOylation, in regulating GSDMD activity and pyroptosis remains unclear.
Yuhua Shi, Xinyue Li, Weilv Xu, Yumeng Wang, Lu Dong, Danyue Li, Suhui He, Yang Yang, Nan Chen, Xinyu Fu, Fushan Shi   +10 more
openaire   +2 more sources

Targeting GSDMD JX06 inhibits PANoptosis and multiple organ injury

Biochemical Pharmacology
Multiple organ dysfunction syndrome (MODS) is the major cause of mortality of patients in intensive care units. The elusive mechanisms of tissue damage in MODS and limited therapeutic options encourage us to seek effective therapies to MODS. PANoptosis has recently been proven to be the key player in both heat stress and sepsis-mediated MODS. Therefore,
Shiyi, Chen, Guo-Dong, Wu, Tongfu, Li, Jiacheng, Jiang, Yuqing, Zhong, Dong, Sun, Feng, Qian, Long Shuang, Huang   +7 more
openaire   +2 more sources

GSDMD-mediated pyroptosis: molecular mechanisms, diseases and therapeutic targets

Molecular Biomedicine
Abstract Pyroptosis is a regulated form of inflammatory cell death in which Gasdermin D (GSDMD) plays a central role as the key effector molecule. GSDMD-mediated pyroptosis is characterized by complex biological features and considerable heterogeneity in its expression, mechanisms, and functional outcomes across various tissues, cell types ...
Yujuan Li, Bin Guo
exaly   +4 more sources

A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis

Nature Cell Biology
Gasdermin D (GSDMD) is the executor of pyroptosis, which is important for host defence against pathogen infection. Following activation, caspase-mediated cleavage of GSDMD releases an amino-terminal fragment (GSDMD-NT), which oligomerizes and forms pores in the plasma membrane, leading to cell death and release of proinflammatory cytokines. The spatial
Jian Zhang, Daichao Xu
exaly   +3 more sources

Analyzing Caspase-8-Dependent GSDMD Cleavage in Response to Yersinia Infection

2023
Caspase-8 is best known to drive an immunologically silent form of cell death known as apoptosis. However, emerging studies revealed that upon pathogen inhibition of innate immune signalling, such as during Yersinia infection in myeloid cells, caspase-8 associates with RIPK1 and FADD to trigger a proinflammatory death-inducing complex.
Felicia Hui Min, Chan, Kaiwen W, Chen
openaire   +2 more sources

Mucus needs GSDMD

Nature Immunology, 2022
openaire   +2 more sources

Gastrodenol suppresses NLRP3/GSDMD mediated pyroptosis and ameliorates inflammatory diseases

Cellular Immunology
Pyroptosis, a form of inflammatory programmed cell death, plays a pivotal role in the pathogenesis of various diseases. This process is primarily mediated by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 (NLRP3).
Peipei Chen, Yunshu Wang, Huaiping Tang, Zhuo Liu, Jing Wang, Tingting Wang, Yun Xu, Sen-Lin Ji   +7 more
openaire   +2 more sources

Igniting hope: Harnessing NLRP3 inflammasome-GSDMD-mediated pyroptosis for cancer immunotherapy

Life Sciences
In the contemporary landscape of oncology, immunotherapy, represented by immune checkpoint blockade (ICB) therapy, stands out as a beacon of innovation in cancer treatment. Despite its promise, the therapy's progression is hindered by suboptimal clinical response rates.
Ling-Rui, Li, Lei, Chen, Zhi-Jun, Sun
openaire   +2 more sources