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Activation of GSDMD contributes to acute kidney injury induced by cisplatin [PDF]

American Journal of Physiology - Renal Physiology, 2020
Cisplatin is one of the most effective antitumor agents, but its clinical use is highly limited by its severe side effects, especially nephrotoxicity. Recently, the active form of gasdermin D (GSDMD), termed GSDMD-N, was identified to mediate pyroptotic inflammatory cell death in several diseases. However, the role of the GSDMD-N fragment in cisplatin-
Aihua Zhang, Songming Huang, Zhanjun Jia   +2 more
exaly   +3 more sources

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GSDMD deficiency drives immunopathology in cutaneous leishmaniasis

The Journal of Immunology, 2022
Abstract Cutaneous leishmaniasis is a neglected tropical disease that results in severe, chronic lesions that are frequently resistant to parasite-directed therapy. Studies in patients and murine models indicate that NLRP-3 dependent IL-1β release is associated with more severe disease and treatment failure.
Christina K Go, James Grayczyk, Igor E Brodsky, Phillip A Scott   +3 more
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Hirudin ameliorates diabetic nephropathy by inhibiting Gsdmd-mediated pyroptosis

Cell Biology and Toxicology, 2021
Our group previously reported that hirudin ameliorated diabetic nephropathy (DN) in streptozotocin (STZ)-injected rats, but the mechanism remained largely unknown. Therefore, we further explored its possible mechanism. We subcutaneously injected 5 U hirudin into STZ-induced WT mice or Gasdermin D (Gsdmd)-/- (KO) mice daily for 12 weeks, respectively ...
Jiarui, Han, Zhenkui, Zuo, Xiujie, Shi, Yage, Zhang, Zining, Peng, Yufeng, Xing, Xinxin, Pang   +6 more
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IRF2 transcriptionally induces GSDMD expression for pyroptosis

Science Signaling, 2019
Pyroptosis requires the induction of gasdermin D expression by the transcription factor IRF2.
Nobuhiko Kayagaki, Bettina L. Lee, Irma B. Stowe, Opher S. Kornfeld, Karen O'Rourke, Kathleen M. Mirrashidi, Benjamin Haley, Colin Watanabe, Merone Roose-Girma, Zora Modrusan, Sarah Kummerfeld, Rohit Reja, Yafei Zhang, Vicky Cho, T. Daniel Andrews, Lucy X. Morris, Christopher C. Goodnow, Edward M. Bertram, Vishva M. Dixit   +18 more
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SUMOylation regulates GSDMD stability and pyroptosis

International Immunopharmacology
Various post-translational modifications (PTMs), such as palmitoylation, acetylation, and ubiquitination, have been shown to regulate pyroptosis. However, the role of small ubiquitin-like modifier (SUMO) modification, known as SUMOylation, in regulating GSDMD activity and pyroptosis remains unclear.
Yuhua Shi, Xinyue Li, Weilv Xu, Yumeng Wang, Lu Dong, Danyue Li, Suhui He, Yang Yang, Nan Chen, Xinyu Fu, Fushan Shi   +10 more
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Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens

Trends in Immunology, 2023
In a recent article, He et al. report that, in response to dietary protein antigens, mouse intestinal epithelial cells (IECs) accumulate a newfound 13-kDa N terminus of gasdermin D (GSDMD-N13), cleaved by caspase-3/7. Unlike the pyroptotic 30-kDa fragment, GSDMD-N13 translocates to the nucleus, inducing CIITA and major histocompatibility complex class ...
Liam B. Healy, Gang Du, Hao Wu
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GSDMD-mediated pyroptosis: molecular mechanisms, diseases and therapeutic targets

Molecular Biomedicine
Abstract Pyroptosis is a regulated form of inflammatory cell death in which Gasdermin D (GSDMD) plays a central role as the key effector molecule. GSDMD-mediated pyroptosis is characterized by complex biological features and considerable heterogeneity in its expression, mechanisms, and functional outcomes across various tissues, cell types ...
Li Yujuan
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GSDMD-mediated pyroptosis in retinal vascular inflammatory diseases: a review

International Ophthalmology, 2022
Pyroptosis is a newly discovered form of programmed pro-inflammatory cell death. The main signaling pathways include the classical scorch death pathway that depends on NLRP3 inflammatory vesicles and other activation caspase-1 and the non-classical scorch death pathway that depends on caspase-4 /5/11. The substrate of all inflammatory caspases is GSDMD;
Li, Xiaodong, Xie, Xuejun
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mTORC1-Dependent and GSDMD-Mediated Pyroptosis in Developmental Sevoflurane Neurotoxicity

Molecular Neurobiology, 2022
Developmental sevoflurane exposure leads to neuronal cell death, and subsequent learning and memory cognitive defects. The underlyi\ng mechanism remains to be elucidated. Gasdermin D (GSDMD)-mediated pyroptosis is a form of inflammatory cell death and participates in a variety of neurodegenerative diseases.
Wang, Wen-Yuan, Yi, Wan-Qing, Hu, Qi-Yun, Liu, Yu-Si, Qian, Shao-Jie, Liu, Jin-Tao, Mao, Hui, Cai, Fang, Yang, Hui-Ling   +8 more
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Identification of Molecular Correlations of GSDMD with Pyroptosis in Alzheimer's Disease

Combinatorial Chemistry & High Throughput Screening
Aim: An analysis of bioinformatics and cell experiments was performed to verify the relationship between gasdermin D (GSDMD), an executive protein of pyroptosis, and Alzheimer's disease (AD). Methods: The training set GSE33000 was utilized to identify differentially expressed genes (DEGs) in both the AD group and control group, as well as in the ...
Tangtang Song, Yan Chen, Chen Li, Yinhui Yao, Shuai Ma, Yazhen Shang, Jianjun Cheng   +6 more
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