Results 171 to 180 of about 13,805 (203)

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance The protein gasdermin D (GSDMD) is the physiological substrate of inflammatory caspases and plays key roles in cell pyroptosis upon microbial infection and associated danger signals. GSDMD, as well as other gasdermin members, can bind lipid and form pore structures to induce pyroptosis.
Hui Yang, Chaoneng Ji, Jianhua Gan
exaly   +3 more sources

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis [PDF]

Cell, 2020
The pyroptosis execution protein GSDMD is cleaved by inflammasome-activated caspase-1 and LPS-activated caspase-11/4/5. The cleavage unmasks the pore-forming domain from GSDMD-C-terminal domain. How the caspases recognize GSDMD and its connection with caspase activation are unknown.
Zilin Li, Yupeng Wang, Feng Shao
exaly   +3 more sources

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HDAC4-mediated deacetylation of GSDMD prevents pyroptosis by inhibiting GSDMD ubiquitination

2023
AbstractGasdermin D (GSDMD) functions as a key pyroptotic executor and induces cytokine secretion after cleavage by inflammatory caspases. However, less is known about the role of posttranslational modifications (PTMs) in GSDMD-mediated pyroptosis. Here, we report that GSDMD can be acetylated at Lysine 248 residue and the acetylation of GSDMD promotes ...
Weilv Xu, Xinyue Li, Danyue Li, Xinyu Fu, Nan Chen, Qian Lv, Yuhua Shi, Suhui He, Lu Dong, Yang Yang, Fushan Shi   +10 more
openaire   +1 more source

Hirudin ameliorates diabetic nephropathy by inhibiting Gsdmd-mediated pyroptosis

Cell Biology and Toxicology, 2021
Our group previously reported that hirudin ameliorated diabetic nephropathy (DN) in streptozotocin (STZ)-injected rats, but the mechanism remained largely unknown. Therefore, we further explored its possible mechanism. We subcutaneously injected 5 U hirudin into STZ-induced WT mice or Gasdermin D (Gsdmd)-/- (KO) mice daily for 12 weeks, respectively ...
Jiarui, Han, Zhenkui, Zuo, Xiujie, Shi, Yage, Zhang, Zining, Peng, Yufeng, Xing, Xinxin, Pang   +6 more
openaire   +2 more sources

GSDMD deficiency drives immunopathology in cutaneous leishmaniasis

The Journal of Immunology, 2022
Abstract Cutaneous leishmaniasis is a neglected tropical disease that results in severe, chronic lesions that are frequently resistant to parasite-directed therapy. Studies in patients and murine models indicate that NLRP-3 dependent IL-1β release is associated with more severe disease and treatment failure.
Christina K Go, James Grayczyk, Igor E Brodsky, Phillip A Scott   +3 more
openaire   +1 more source

Brain endothelial GSDMD activation mediates inflammatory BBB breakdown

Nature
The blood-brain barrier (BBB) protects the central nervous system from infections or harmful substances1; its impairment can lead to or exacerbate various diseases of the central nervous system2-4. However, the mechanisms of BBB disruption during infection and inflammatory conditions5,6 remain poorly defined.
Shao Feng
exaly   +4 more sources

IRF2 transcriptionally induces GSDMD expression for pyroptosis

Science Signaling, 2019
Pyroptosis requires the induction of gasdermin D expression by the transcription factor IRF2.
Nobuhiko Kayagaki, Bettina L. Lee, Irma B. Stowe, Opher S. Kornfeld, Karen O'Rourke, Kathleen M. Mirrashidi, Benjamin Haley, Colin Watanabe, Merone Roose-Girma, Zora Modrusan, Sarah Kummerfeld, Rohit Reja, Yafei Zhang, Vicky Cho, T. Daniel Andrews, Lucy X. Morris, Christopher C. Goodnow, Edward M. Bertram, Vishva M. Dixit   +18 more
openaire   +2 more sources

Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens

Trends in Immunology, 2023
In a recent article, He et al. report that, in response to dietary protein antigens, mouse intestinal epithelial cells (IECs) accumulate a newfound 13-kDa N terminus of gasdermin D (GSDMD-N13), cleaved by caspase-3/7. Unlike the pyroptotic 30-kDa fragment, GSDMD-N13 translocates to the nucleus, inducing CIITA and major histocompatibility complex class ...
Liam B. Healy, Gang Du, Hao Wu
openaire   +2 more sources

mTORC1-Dependent and GSDMD-Mediated Pyroptosis in Developmental Sevoflurane Neurotoxicity

Molecular Neurobiology, 2022
Developmental sevoflurane exposure leads to neuronal cell death, and subsequent learning and memory cognitive defects. The underlyi\ng mechanism remains to be elucidated. Gasdermin D (GSDMD)-mediated pyroptosis is a form of inflammatory cell death and participates in a variety of neurodegenerative diseases.
Wang, Wen-Yuan, Yi, Wan-Qing, Hu, Qi-Yun, Liu, Yu-Si, Qian, Shao-Jie, Liu, Jin-Tao, Mao, Hui, Cai, Fang, Yang, Hui-Ling   +8 more
openaire   +2 more sources

GSDMD-mediated pyroptosis in retinal vascular inflammatory diseases: a review

International Ophthalmology, 2022
Pyroptosis is a newly discovered form of programmed pro-inflammatory cell death. The main signaling pathways include the classical scorch death pathway that depends on NLRP3 inflammatory vesicles and other activation caspase-1 and the non-classical scorch death pathway that depends on caspase-4 /5/11. The substrate of all inflammatory caspases is GSDMD;
Li, Xiaodong, Xie, Xuejun
openaire   +2 more sources