Results 201 to 210 of about 14,672 (225)

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Nature, 2015
Inflammatory caspases (caspase-1, -4, -5 and -11) are critical for innate defences. Caspase-1 is activated by ligands of various canonical inflammasomes, and caspase-4, -5 and -11 directly recognize bacterial lipopolysaccharide, both of which trigger pyroptosis.
Jianjin, Shi, Yue, Zhao, Kun, Wang, Xuyan, Shi, Yue, Wang, Huanwei, Huang, Yinghua, Zhuang, Tao, Cai, Fengchao, Wang, Feng, Shao   +9 more
openaire   +2 more sources

Targeting GSDMD JX06 inhibits PANoptosis and multiple organ injury

Biochemical Pharmacology
Multiple organ dysfunction syndrome (MODS) is the major cause of mortality of patients in intensive care units. The elusive mechanisms of tissue damage in MODS and limited therapeutic options encourage us to seek effective therapies to MODS. PANoptosis has recently been proven to be the key player in both heat stress and sepsis-mediated MODS. Therefore,
Shiyi, Chen, Guo-Dong, Wu, Tongfu, Li, Jiacheng, Jiang, Yuqing, Zhong, Dong, Sun, Feng, Qian, Long Shuang, Huang   +7 more
openaire   +2 more sources

Mucus needs GSDMD

Nature Immunology, 2022
openaire   +2 more sources

GSDMD in regulated cell death: A novel therapeutic target for sepsis

International Immunopharmacology
Sepsis is a life-threatening multi-organ dysfunction syndrome caused by an abnormal host response to infection. Regulated cell death is essential for maintaining tissue homeostasis and eliminating damaged, infected, or aging cells in multicellular organisms.
Xiangli Ma, Yujie Lin, Ling Zhang, Shaoyi Miao, Haidan Zhang, Hongyao Li, Xu Fu, Li Han, Peiwu Li   +8 more
openaire   +2 more sources

A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis

Nature Cell Biology
Gasdermin D (GSDMD) is the executor of pyroptosis, which is important for host defence against pathogen infection. Following activation, caspase-mediated cleavage of GSDMD releases an amino-terminal fragment (GSDMD-NT), which oligomerizes and forms pores in the plasma membrane, leading to cell death and release of proinflammatory cytokines. The spatial
Na Zhang, Jian Zhang, Yuanxin Yang, Hengyue Shan, Shouqiao Hou, Hongwen Fang, Min Ma, Zhongwen Chen, Li Tan, Daichao Xu   +9 more
openaire   +2 more sources

Brain endothelial GSDMD activation mediates inflammatory BBB breakdown

Nature
The blood-brain barrier (BBB) protects the central nervous system from infections or harmful substances1; its impairment can lead to or exacerbate various diseases of the central nervous system2-4. However, the mechanisms of BBB disruption during infection and inflammatory conditions5,6 remain poorly defined.
Chao Wei, Wei Jiang, Ruiyu Wang, Haoyu Zhong, Huabin He, Xinwei Gao, Shilin Zhong, Fengting Yu, Qingchun Guo, Li Zhang, Lisa D. J. Schiffelers, Bin Zhou, Martin Trepel, Florian I. Schmidt, Minmin Luo, Feng Shao   +15 more
openaire   +3 more sources

Efficient Delivery of GSDMD‐N mRNA by Engineered Extracellular Vesicles Induces Pyroptosis for Enhanced Immunotherapy

Small, 2023
Guodong Yang, An-Gang Yang
exaly  

Gasdermin D (GSDMD) Is Upregulated in Psoriatic Skin—A New Potential Link in the Pathogenesis of Psoriasis

International Journal of Molecular Sciences, 2023
Anna Pryczynicz, Dariusz Pawlak, Justyna Hermanowicz   +2 more
exaly  

GSDMD Mediates LPS-Induced Septic Myocardial Dysfunction by Regulating ROS-dependent NLRP3 Inflammasome Activation

Frontiers in Cell and Developmental Biology, 2021
Shanshan Dai, Zhongqiu Lu, Bozhi Ye
exaly  

GSDMD, an executor of pyroptosis, is involved in IL-1β secretion in Aspergillus fumigatus keratitis

Experimental Eye Research, 2021
Chengye Che, Haijing Yan
exaly