Gasdermins: novel mitochondrial pore-forming proteins
Molecular & Cellular Oncology, 2019 Gasdermin proteins have been extensively characterized for their ability to form necrotic pores in the plasma membrane, however, their interactions with other organelles have yet to be described.
Corey Rogers, Emad S. Alnemri
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Gasdermin D–mediated pyroptosis suppresses liver regeneration after 70% partial hepatectomy
Hepatology Communications, 2022 Pyroptosis is a kind of programmed cell death primarily mediated by gasdermin D (GSDMD) and shown to regulate multiple diseases. However, its contribution to liver regeneration, a fine‐tuned tissue repair process mediated primarily by hepatocytes after ...
Xingyu Lv +8 more
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Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture [PDF]
, 2019 Pyroptosis is rapidly emerging as a mechanism of anti-microbial host defense, and of extracellular release of the inflammasome-dependent cytokines interleukin (IL)-1 beta and IL-18, which contributes to autoinflammatory pathology. Caspases 1, 4, 5 and 11
Lamkanfi, Mohamed +4 more
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Gasdermin D-deficient mice are hypersensitive to acute kidney injury [PDF]
, 2022 Signaling pathways of regulated necrosis, such as necroptosis and ferroptosis, contribute to acute kidney injury (AKI), but the role of pyroptosis is unclear. Pyroptosis is mediated by the pore-forming protein gasdermin D (GSDMD).
Anders, Hans-Joachim +17 more
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Di-san junyi daxue xuebao, 2022 Objective To investigate the effect of Th1/Th2 ratio on pyroptosis of placental trophoblast cells in early-onset severe preeclampsia. Methods The clinical data of 55 cases of early-onset severe preeclampsia diagnosed in our hospital from June 2018 to ...
WANG Haijiao +5 more
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Role of High-Mobility Group Box-1 in Liver Pathogenesis [PDF]
, 2019 High-mobility group box 1 (HMGB1) is a highly abundant DNA-binding protein that can relocate to the cytosol or undergo extracellular release during cellular stress or death. HMGB1 has a functional versatility depending on its cellular location.
Huda, Nazmul +3 more
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ASC filament formation serves as a signal amplification mechanism for inflammasomes [PDF]
, 2016 A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase ...
Broz, Petr +4 more
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THE ROLE OF CASPASE-4/11-GASDERMIN D PATHWAY IN PROMOTING VASCULAR INFLAMMATION IN CHRONIC KIDNEY DISEASE [PDF]
, 2021 Chronic kidney disease (CKD) affects 13.4% of adults in America; and 38% in people aged 65 years or older[1]. In addition, cardiovascular disease (CVD) is the leading cause of death in CKD patients with end-stage kidney disease.
0000-0002-0877-7186, SUN, YU
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GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death [PDF]
, 2016 Pyroptosis is a lytic type of cell death that is initiated by inflammatory caspases. These caspases are activated within multi-protein inflammasome complexes that assemble in response to pathogens and endogenous danger signals.
Broz, Petr +9 more
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GSDMD-mediated pyroptosis: molecular mechanisms, diseases and therapeutic targets [PDF]
Molecular BiomedicineAbstract Pyroptosis is a regulated form of inflammatory cell death in which Gasdermin D (GSDMD) plays a central role as the key effector molecule. GSDMD-mediated pyroptosis is characterized by complex biological features and considerable heterogeneity in its expression, mechanisms, and functional outcomes across various tissues, cell types ...
Yujuan Li, Bin Guo
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