Results 61 to 70 of about 18,138 (288)

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition [PDF]

, 2019
The nucleotide-binding-domain (NBD)-and leucine-rich repeat (LRR)-containing (NLR) family, pyrin-domain-containing 3 (NLRP3) inflammasome drives pathological inflammation in a suite of autoimmune, metabolic, malignant, and neurodegenerative diseases ...
Demon, Dieter, Fossoul, Amelie, Kayagaki, Nobuhiko, Konvalinka, Jan, Kostka, Libor, Lamkanfi, Mohamed, Lee, Bettina L, Pham, Victoria C, Sacha, Pavel, Simon, Petr, Staben, Steven T, Stivala, Craig E, Stowe, Irma B, Subrt, Vladimir, Van Hauwermeiren, Filip, Vande Walle, Lieselotte, Viana Saavedra, Pedro Henrique, Yamazoe, Sayumi   +17 more
core   +1 more source

Mincle-Gsdmd-Mediated Release of Il-1β Small Extracellular Vesicles From Hepatic Macrophages in Ethanol-Induced Liver Injury [PDF]

, 2023
BACKGROUND: Macrophage-inducible C-type lectin (Mincle) is expressed on hepatic macrophages and senses ethanol (EtOH)-induced danger signals released from dying hepatocytes and promotes IL-1β production.
Bulek, Katarzyna, Dasarathy, Jaividhya, Dasarathy, Srinivasan, Li, Xiaoxia, Liu, Weiwei, McMullen, Megan R, Nagy, Laura E, Wang, Han, Welch, Nicole, Wu, Xiaoqin, Zhang, Quanri, Zhang, Renliang   +11 more
core   +2 more sources

Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions [PDF]

, 2016
Genetic association studies provide evidence for a substantial polygenic component to schizophrenia, although the neurobiological mechanisms underlying the disorder remain largely undefined.
Al-Saraj, S, Dempster, E, Hannon, E, Knox, O, Macdonald, R, Mill, J, Pidsley, R, Schalkwyk, LC, Spiers, H, Troakes, C, Turecki, G, Viana, J   +11 more
core   +4 more sources

Acute ocular hypertension induced pyropotosis in rat retinal ganglion cells and protective effect of inhibiting Caspase-1 in rat model

Di-san junyi daxue xuebao, 2022
Objective To investigate the protective effect of pyroptosis and anti-Caspase-1 treatment on retinal ganglion cells (RGCs) in rats with acute ocular hypertension.
SUN Yulin, LIU Ting
doaj   +1 more source

Legionella pneumophila strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin [PDF]

, 2017
International audienceThe human pathogen Legionella pneumophila must evade host cell death signaling to enable replication in lung macrophages and to cause disease. After bacterial growth, however, L.
Abraham, Gilu, Dorn, Gerald W, II, Flavell, Richard A, Han, Qingqing, Hunot, Stephane, Masters, Seth L, Naderer, Thomas, Seidi, Azadeh, Speir, Mary, Vince, James E, Vogrin, Adam   +10 more
core   +4 more sources

Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling [PDF]

, 2022
Amino-terminal fragments from proteolytically cleaved gasdermins (GSDMs) form plasma membrane pores that enable the secretion of interleukin-1β (IL-1β) and IL-18.
Abu-Amer, Yousef, Alippe, Yael, Brodt, Michael D, Hao, Dingjun, Hu, Huimin, Mbalaviele, Gabriel, Shen, Jie, Silva, Matthew J, Sun, Kai, Wang, Chun, Xiao, Jianqiu, Yang, Tong, Yuan, Luorongxin   +12 more
core   +2 more sources

P2X7 receptor-mediated TG2 externalization: a link to inflammatory arthritis? [PDF]

, 2016
Transglutaminases have important roles in stabilizing extracellular protein assemblies in tissue repair processes but some reaction products can stimulate immune activation, leading to chronic inflammatory conditions or autoimmunity.
Aeschlimann, Daniel, Knauper, Vera
core   +1 more source

TR4 worsen urosepsis by regulating GSDMD

European Journal of Medical Research
Abstract Background Urosepsis is a life-threatening organ disease in which pathogenic microorganisms in the urine enter the blood through the vessels, causing an imbalance in the immune response to infection. The aim of this study was to elucidate the role of testicular orphan receptor 4 (TR4) in urosepsis.
Huan Wang, Shibin Zhu, Zhenwei Zhou, Zhenghui Wang, Wei Zhuang, Dingwei Xue, Zeyi Lu, Qiming Zheng, Lifeng Ding, Liangliang Ren, Wenqing Luo, Ruyue Wang, Guangju Ge, Liqun Xia, Gonghui Li, Haiyang Wu   +15 more
openaire   +3 more sources

Инфламмасомы и пироптоз эпителиальных клеток кишечника: вклад в развитие болезни Крона и неспецифического язвенного колита [PDF]

, 2019
ИНФЛАММАСОМЫПИРОПТОЗКЛЕТКИ СМЕРТЬЭПИТЕЛИОЦИТЫЭПИТЕЛИАЛЬНЫЕ КЛЕТКИКИШЕЧНИКА ВОСПАЛИТЕЛЬНЫЕ БОЛЕЗНИКРОНА БОЛЕЗНЬИЛЕИТ РЕГИОНАЛЬНЫЙИЛЕИТ ТЕРМИНАЛЬНЫЙИЛЕОКОЛИТЭНТЕРИТ ГРАНУЛОМАТОЗНЫЙКОЛИТ ЯЗВЕННЫЙПРОКТОКОЛИТ ЯЗВЕННЫЙПРОКТОЛИТ ГЕМОРРАГИЧЕСКИЙРЕКТОКОЛИТ ...
Ткаченко, А. С.
core   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source