Results 71 to 80 of about 18,138 (288)

Electrostatic influence on IL-1 transport through the GSDMD pore

Proceedings of the National Academy of Sciences, 2022
Significance Gasdermin D (GSDMD) forms large pores that channel the release of alarmins, including interleukin-1 (IL-1) family cytokines, from living cells. IL-1 is synthesized as an inactive cytosolic precursor known as pro-IL-1, which is proteolytically processed into the active mature IL-1 in response to inflammasome activation or other ...
Xie, Wen Jun, Xia, Shiyu, Warshel, Arieh, Wu, Hao   +3 more
openaire   +2 more sources

NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease. [PDF]

, 2017
Inflammasomes are cytosolic multiprotein complexes that initiate protective immunity in response to infection, and can also drive auto-inflammatory diseases, but the cell types and signalling pathways that cause these diseases remain poorly understood ...
Nichols, Randilea D, Vance, Russell E, von Moltke, Jakob   +2 more
core   +2 more sources

Compound loss of GSDMD and GSDME function is necessary to achieve maximal therapeutic effect in colitis [PDF]

, 2022
Gasdermin D (GSDMD) and gasdermin E (GSDME) perpetuate inflammation by mediating the release of cytokines such as interleukin-1β (IL-1β) and IL-18. However, not only are the actions of GSDMD in colitis still controversial, but its interplay with GSDME in
Abu-Amer, Yousef, Mbalaviele, Gabriel, Sun, Kai, Wang, Chun, Xiao, Jianqiu   +4 more
core   +2 more sources

Zinc‐Containing Bioactive Glass Programs Macrophage Polarization through Extracellular Traps Regulation for Enhanced Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Zinc‐containing bioactive glass (ZnBG) promotes diabetic wound healing by regulating macrophage extracellular traps (METs). Specifically, ZnBG reduces oxidative stress and inhibits the PAD4 and NLRP3/caspase‐1/GSDMD signaling pathways, thereby suppressing MET formation.
RuiYang Sun, XueBo Wei, ZhuoYang Song, JunJun Luo, JingYi Ye, YinNan Zhang, LiFei Zhu, Jie Gao, Hongyu Zhang, Hong Zhu, Xin Wang, Ke Xu   +11 more
wiley   +1 more source

Disulfiram alleviates pristane-induced lupus via inhibiting GSDMD-mediated pyroptosis

Cell Death Discovery, 2022
AbstractActivation of multiple inflammasomes in monocytes/macrophages is associated with the pathogenesis of systemic lupus erythematosus (SLE). Gasdermin D (GSDMD)-mediated pyroptosis, a common consequence of multiple activated inflammasomes, is a programmed cell death with strong inflammatory responses.
Lili Zhuang, Xiaoqing Luo, Shufan Wu, Zhangmei Lin, Yanan Zhang, Zeqing Zhai, Fangyuan Yang, Yehao Li, Jian Zhuang, Guihu Luo, Wenchao Xu, Yi He, Erwei Sun   +12 more
openaire   +3 more sources

Irigenin Modulates BL‐Induced Pyroptosis in Retinal Pigment Epithelial Cells Through p38 MAPK and NFκB Pathways [PDF]

J Biochem Mol Toxicol
Irigenin alleviates blue light‐induced RPE cell damage by inhibiting NLRP3 inflammasome and p38/NF‐κB signalling, showing potential for AMD prevention. ABSTRACT Age‐related macular degeneration (AMD), a primary cause of vision loss among older adults, is strongly associated with inflammatory processes.
Su I, Yeh K, Lee C, Lin S, Chiang C, Chen C, Chen W, Tseng C, Lu Y, Kuan Y.   +9 more
europepmc   +2 more sources

The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. [PDF]

, 2018
Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome ...
Alnemri, Emad S., Champagne, Claudia, Doiron, Karine, Douglas, Todd, Leiva-Torres, Gabriel André, Mayes, Lindsey, Rodrigue-Gervais, Ian Gaël, Saleh, Maya, Vanié, Paulin, Vidal, Silvia M.   +9 more
core   +4 more sources

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

Gasdermins in Apoptosis: New players in an Old Game. [PDF]

, 2019
Apoptosis is a form of programmed cell death (PCD) that plays critical physiological roles in removing superfluous or dangerous cell populations that are unneeded or threatening to the health of the host organism.
Alnemri, Emad S., Rogers, Corey
core   +1 more source

Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis

Advanced Science, EarlyView.
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao, Shan Xu, You Zou, Rui Yang, Han Zheng, Jia‐Yu Liu, Hui‐Ming Fan, Yuan‐Yuan Zhang, Yong‐Gang Kong, Wo‐Er Jiao, Shi‐Ming Chen   +10 more
wiley   +1 more source