Results 81 to 90 of about 18,138 (288)

Circ-USP9X interacts with EIF4A3 to promote endothelial cell pyroptosis by regulating GSDMD stability in atherosclerosis

Clinical and Experimental Hypertension, 2023
Endothelial pyroptosis is a pathological mechanism of atherosclerosis (AS). Circular RNAs (circRNAs) are vital in AS progression by regulating endothelial cell functions.
Shengkai Xu, Yishan Ge, Xuebin Wang, Wei Yin, Xiaoqing Zhu, Jie Wang, Shigang Qiao   +6 more
doaj   +1 more source

Gasdermin D Plays an Oncogenic Role in Glioma and Correlates to an Immunosuppressive Microenvironment

Biomolecules, 2023
Background: Understanding the molecular mechanisms driving oncogenic processes in glioma is important in order to develop efficient treatments. Recent studies have proposed gasdermin D (GSDMD) as a newly discovered pyroptosis executive protein associated
Mengyuan Li, Ping Jiang, Shuhua Wei, Yuhan Yang, Liting Xiong, Junjie Wang, Chunxiao Li   +6 more
doaj   +1 more source

Whole-exome sequencing validates a preclinical mouse model for the prevention and treatment of cutaneous squamous cell carcinoma [PDF]

, 2017
Cutaneous squamous cell carcinomas (cSCC) are among the most common and highly mutated human malignancies. Solar UV radiation is the major factor in the etiology of cSCC. Wholeexome sequencing of 18 microdissected tumor samples (cases) derived from SKH-1
Aikseng Ooi, Alan Evans, Albena T. Dinkova-Kostova, Brandon Praslicka, Catherine A. Harwood, Charlotte M. Proby, Elena V. Knatko, Harwood, Jennings, Karin J. Purdie, Kim, Knatko, Leiter, Levine, Maureen Higgins, Sutherland, Varghese   +16 more
core   +2 more sources

Construction of PANoptosis‐Inhibiting Carbonized Polymer Dots via Machine Learning Potential for Mitigating Chemodrug‐Induced Nephrotoxicity

Advanced Science, EarlyView.
An enhanced sampling method is developed for molecular dynamics based on trained machine learning force fields to guide the construction of PANoptosis‐inhibiting carbonized polymer dots (Lu‐CDs) derived from a flavonoid compound for treating chemodrug‐induced nephrotoxicity.
Xinchen Liu, Jiaxin Zhang, Xiangyu Yan, Nuo Li, Yu‐Chao Dong, Zihao Wang, Daowei Li, Yong Du, Huan Wang   +8 more
wiley   +1 more source

Theory of improved spectral purity in index patterned Fabry-Perot lasers [PDF]

, 2005
The spectral purity of a ridge waveguide Fabry-Perot laser can be improved by patterning the effective refractive index seen by an optical mode propagating in the cavity.
Born M., Bracewell R., E. P. O’Reilly, S. O’Brien   +3 more
core   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

GSDMD-mediated pyroptosis restrains intracellular Chlamydia trachomatis growth in macrophages

Frontiers in Cellular and Infection Microbiology, 2023
Pyroptosis, a type of programmed necrosis associated with inflammatory, is a host defense mechanism against microbial infections. Although Chlamydia has been shown to induce pyroptosis, whether pyroptosis directly impacts the growth of Chlamydia has not been demonstrated. In this study, we found that C.
Ping Jiang, Hongzhi Chen, Xiaojing Feng, Huiqi Xie, Mengjie Jiang, Danning Xu, Haoneng Tang, Ningjie Zhang, Jianlin Chen, Lei Zhang, Lingli Tang   +10 more
openaire   +3 more sources

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

Ceramide induces pyroptosis through TXNIP/NLRP3/GSDMD pathway in HUVECs

BMC Molecular and Cell Biology, 2022
Abstract Background Pyroptosis of endothelial cells is a new cause of endothelial dysfunction in multiple diseases. Ceramide acts as a potential bioactive mediator of inflammation and increases vascular endothelial permeability in many diseases, whether it can aggravate vascular endothelial injury by inducing cell ...
Fangfang Liu, Yangyang Zhang, Yining Shi, Kai Xiong, Fugui Wang, Jin Yang   +5 more
openaire   +3 more sources

Impairing Gasdermin D-mediated pyroptosis is protective against retinal degeneration

Journal of Neuroinflammation, 2023
Background Inflammasome activation and the subsequent release of pro-inflammatory cytokines including Interleukin 1β (IL-1β) have been widely reported to contribute to the progression of retinal degenerations, including age-related macular degeneration ...
Rakshanya Sekar, Yvette Wooff, Adrian V. Cioanca, Melan Kurera, Chinh Ngo, Si Ming Man, Riccardo Natoli   +6 more
doaj   +1 more source