Results 101 to 110 of about 269,348 (283)

Are Supershells Powered by Multiple Supernovae? Modeling the Radio Pulsar Population Produced by OB Associations

, 2004
Traditional searches for radio pulsars have targeted individual small regions such as supernova remnants or globular clusters, or have covered large contiguous regions of the sky.
Biggs J. D., Bryan M. Gaensler, Chiosi C., Haslam C. G. T., Johnston S., Kuijken K., Lorimer D. R., Lorimer D. R., Lyne A. G., Manchester R. N., McWillian A., Phinney E. S., Rosalba Perna, Stollman G. M., Tenorio-Tagle G., Vivekanand M.   +15 more
core   +2 more sources

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

REAÇÕES TRANSFUSIONAIS: CARACTERIZAÇÃO DAS REAÇÕES TRANSFUSIONAIS ADVERSAS OCORRIDAS EM HOSPITAIS ATENDIDOS PELO GRUPO GSH EM TODO PAÍS

Hematology, Transfusion and Cell Therapy
Objetivo: Descrever as principais reações transfusionais imediatas e tardias ocorridas em hospitais atendidos pelo Grupo GSH no país. Material e métodos: O levantamento dos dados, foi realizado pelas informações obtidas do sistema informatizado do Grupo ...
RA Bento, KJD Olio, LPS Fontenele, DSF Costa, SP Menchão, GDRF Cazeca, TOSB Marchesi, JAD Santos   +7 more
doaj   +1 more source

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

ÍNDICE DE ALOIMUNIZAÇÃO ERITROCITÁRIA EM PACIENTES ATENDIDOS PELAS AGÊNCIAS TRANSFUSIONAIS DO GRUPO GSH NÍVEL NACIONAL

Hematology, Transfusion and Cell Therapy
Objetivo: Analisar a incidência de aloimunização em pacientes internados nos hospitais das agências transfusionais do país atendidas pela Grupo GSH. Material e métodos: Estudo retrospectivo realizado através do levantamento de dados obtidos do sistema ...
KJD Olio, RA Bento, LPS Fontenele, DSF Costa, SP Menchão, GDRF Cazeca, TOSB Marchesi, JAD Santos   +7 more
doaj   +1 more source

The effect of glutathione on human nuclear chromatin decondensation [PDF]

Introduction: During spermiogendsis, sperm chromatin histones are replaced by protamine. After fertilization, the sprem nucleus is decondenced by glutathione (GSH).
رضازاده ولوجردی, مجتبی, سقا, محسن, نصر اصفهاني, محمد حسين   +2 more
core  

Beyond Catalytic Therapy: Copper‐Paeonol Nanozymes Disrupt Fascin‐Mediated Actin Bundling to Suppress Tumor Growth and Metastasis

Advanced Science, EarlyView.
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi   +8 more
wiley   +1 more source

PROPOSTA DE AJUSTE DO PROTOCOLO DE RESERVA CIRÚRGICA DE HEMOCOMPONENTES DE UM HOSPITAL COM BASE NA METODOLOGIA MSBOS

Hematology, Transfusion and Cell Therapy
Introdução: Frequentemente, como relatado em literatura e visto na prática, há um excesso de pedidos de reserva de hemocomponentes em cirurgias eletivas, o que extrapola as necessidades reais, gerando desnecessariamente sobrecarga nos serviços de banco ...
EAF Oliveira, MCM Campos, LPS Fontenele, FCV Perini, LFF Dalmazzo   +4 more
doaj   +1 more source

Reduction of Oxidative Stress and Storage Lesions (RCSL) in Red Blood Cells: Analysis of Ascorbic Acid (AA), N-Acetylcysteine amide (AD4), and Serotonin (5-HT) [PDF]

, 2018
Oxidative stress is a common occurrence in red blood cell (RBC) storage in blood banks throughout the world. Typically RBC units stored under routine standard protocol (stored in SAGM-CPD additive solution) can only be kept up to forty-two days for ...
Gadiraju, Shanmuka
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source