Results 111 to 120 of about 360,657 (334)

A IMPLANTAÇÃO DA TROCA AUTOMATIZADA DE GLÓBULOS VERMELHOS (ERITROCITAFÉRESE) COMO MODALIDADE DE TRATAMENTO EM PACIENTES COM DOENÇA FALCIFORME: EXPERIÊNCIA DO AMBULATÓRIO TRANSFUSIONAL SERUM CENTRO – RJ

Hematology, Transfusion and Cell Therapy
Introdução: A Doença Falciforme (DF) é uma doença genética e hereditária caracterizada por uma mutação no gene que produz a hemoglobina (HbA), fazendo surgir uma hemoglobina mutante denominada S (HbS).
PG Moura, MS Simão, LA Nunes, RL Lima, L Avelar, FN Lima, PCP Grossi, IG Claudio, F Akil   +8 more
doaj   +1 more source

End‐to‐End Sensing Systems for Breast Cancer: From Wearables for Early Detection to Lab‐Based Diagnosis Chips

Advanced Materials Technologies, EarlyView.
This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane, Lyn I. Jones, Richard M. Martin, Helen Winter, Faezeh Arab Hassani   +4 more
wiley   +1 more source

Are Supershells Powered by Multiple Supernovae? Modeling the Radio Pulsar Population Produced by OB Associations

, 2004
Traditional searches for radio pulsars have targeted individual small regions such as supernova remnants or globular clusters, or have covered large contiguous regions of the sky.
Biggs J. D., Bryan M. Gaensler, Chiosi C., Haslam C. G. T., Johnston S., Kuijken K., Lorimer D. R., Lorimer D. R., Lyne A. G., Manchester R. N., McWillian A., Phinney E. S., Rosalba Perna, Stollman G. M., Tenorio-Tagle G., Vivekanand M.   +15 more
core   +2 more sources

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, EarlyView.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

CAPITAL SOCIAL DE DOADORES DE GRANULÓCITOS: RELATO DE CASO

Hematology, Transfusion and Cell Therapy
Introdução: A transfusão de granulócitos é uma modalidade terapêutica útil ao controle de infecções bacterianas ou fúngicas em pacientes neutropênicos, viável quando há colapso terapêutico com fármacos.
RE Almeida, KA Motta, PG Moura, L Avelar, T Martinscarvalho, LP Leandro, JAR Billo, F Akil   +7 more
doaj   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Adaptation to G93A superoxide dismutase 1 in a motor neuron cell line model of amyotrophic lateral sclerosis. The role of glutathione [PDF]

, 2009
Motor neuron degeneration in amyotrophic lateral sclerosis involves oxidative damage. Glutathione (GSH) is critical as an antioxidant and a redox modulator.
AND LAVINIA CANTONI, D'ALESSANDRO, GIUSEPPINA, ELISABETTA BABETTO, LAURA CONFORTI, MILENA RIZZARDINI, SILVIA TARTARI   +5 more
core   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

REAÇÃO HEMOLÍTICA AGUDA APÓS TRANSFUSÃO DE PLAQUETAS ABO INCOMPATÍVEL: RELATO DE CASO

Hematology, Transfusion and Cell Therapy
Introdução: A transfusão de concentrado de plaquetas (CP) deve idealmente ser ABO-isogrupo, entretanto o uso de CP não idênticas não são incomuns devido baixa disponibilidade de todos os tipos sanguíneos e a vida-média curta de 5 dias destes ...
SMC Lira, IGP Silva, JPL Amorim, EC Ferreira, PDS Teixeira, WWV Sampaio, M Valvasori, LFF Dalmazzo   +7 more
doaj   +1 more source

Biophysical Features of Bacillithiol, the Glutathione Surrogate of Bacillus subtilis and other Firmicutes [PDF]

, 2013
Bacillithiol (BSH) is the major low-molecular-weight (LMW) thiol in many low-G+C Gram-positive bacteria (Firmicutes). Evidence now emerging suggests that BSH functions as an important LMW thiol in redox regulation and xenobiotic detoxification, analogous
Arbach, Miriam, Groom, Murree, Hamilton, Chris J., Macdonald, Colin J., Roberts, Alexandra A., Sharma, Sunil V.   +5 more
core   +1 more source