Results 231 to 240 of about 360,657 (334)

A “Hot Spring” Mimetic Aerogel Loaded with Multiple Amino Acids Modulates the Chronic Inflammatory Microenvironment Through Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
The SrCuSi4O₁₀ bioceramic particles mimic the effects of hot spring therapy by increasing the local wound temperature, which enhances the absorption of amino acids and stimulates cell metabolism. The amino acid uptake supports cellular glutathione redox reactions, helping to mitigate oxidative stress.
Bo Li   +7 more
wiley   +1 more source

Photocatalytic Micro/Nanomotors Functioning in the Near‐Infrared Window for Biomedical Applications

open access: yesAdvanced Science, EarlyView.
This review focuses on near‐infrared responsive photocatalytic micro/nanomotors based on inorganic materials, with particular emphasis on minimally invasive biomedical applications. It discusses material strategies for achieving near‐infrared responsiveness, including heterostructure construction, upconversion nanoparticle integration, defect ...
Yufen Chen   +2 more
wiley   +1 more source

Metal‐Supramolecular Drug Delivery System Empowered Meningeal Lymphatic Vessels‐Bridged Intracranial‐Peripheral Dual Immune Modulation for Reversing Glioblastoma Immune Suppression

open access: yesAdvanced Science, EarlyView.
A novel metal‐supramolecular nanoplatform (FLM@VC) enables efficient brain delivery via meningeal lymphatic vessels (MLVs), bypassing the blood‐brain barrier (BBB) through subcutaneous administration. It reprograms tumor‐associated macrophages (TAMs) and remodels the MLVs to promote DC trafficking and CD8+ T cell activation.
Chenxi Zhang   +11 more
wiley   +1 more source

KMT2C Loss Promotes NF2‐Wildtype Meningioma Progression and Ferroptosis Sensitivity via Epigenetic Repression of Hippo Signaling

open access: yesAdvanced Science, EarlyView.
In NF2–wild‐type meningiomas, loss of the epigenetic regulator KMT2C suppresses NF2 transcription and inactivates Hippo signaling, driving tumor progression and increasing ferroptosis sensitivity. Restoration of histone acetylation reverses these effects and inhibits tumor growth, identifying KMT2C as a key regulator linking epigenetic control, NF2 ...
Liuchao Zhang   +13 more
wiley   +1 more source

Glutathionylated DNA adducts accumulate in mitochondrial DNA and are regulated by AP endonuclease 1 and tyrosyl-DNA phosphodiesterase 1. [PDF]

open access: yesProc Natl Acad Sci U S A
Chen YH   +10 more
europepmc   +1 more source

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