Results 251 to 260 of about 273,251 (302)
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GSH and analogs in antiviral therapy
Molecular Aspects of Medicine, 2009Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. Its de novo and salvage synthesis serves to maintain a reduced cellular environment. GSH is the most powerful intracellular antioxidant and plays a role in the detoxification of a variety of electrophilic compounds and peroxides via catalysis by glutathione-S ...
Alessandra Fraternale +2 more
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Small
AbstractGlutathione (GSH) is the primary antioxidant in cells, and GSH consumption will break the redox balance in cells. Based on this, a method that uses high concentrations of GSH in the tumor microenvironment to trigger the redox reaction of Cu(II) to generate copper nanoprobes with fluorescence and tumor growth inhibition properties is proposed ...
Xuemei Wang
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AbstractGlutathione (GSH) is the primary antioxidant in cells, and GSH consumption will break the redox balance in cells. Based on this, a method that uses high concentrations of GSH in the tumor microenvironment to trigger the redox reaction of Cu(II) to generate copper nanoprobes with fluorescence and tumor growth inhibition properties is proposed ...
Xuemei Wang
exaly +3 more sources
Modulation of endothelial GSH concentrations: effect of exogenous GSH and GSH monoethyl ester
Journal of Applied Physiology, 1989We studied the effects of exogenous glutathione (GSH) and GSH monoethyl ester (GSH-MEE) on the enhancement of endothelial GSH concentrations. The preparation of GSH-MEE used contained 91% GSH-MEE, approximately 9% GSH diethyl ester (GSH-DEE) and a trace amount of GSH.
M F, Tsan, J E, White, C L, Rosano
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Fluorometric estimation of GSH-OPT
Analytical Biochemistry, 1968Abstract Cohn and Lyle (1) have reported that under certain conditions reduced glutathione (GSH) and o-phthalaldehyde (OPT) react to produce a highly fluorescent compound, and that no other compound tested, including GSSG and 16 other sulfhydryl, disulfide, or thioether compounds, yields fluorescence with OPT under those conditions.
T L, McNeil, L V, Beck
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Divergent effects of intravenous GSH and cysteine on renal and hepatic GSH
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1992There is a growing interest in the therapeutic use of sulfhydryls. To assess the effect of glutathione (GSH) and cysteine on the cellular thiol status, thiols were administered intravenously to rats in doses ranging from 1.67 to 8.35 mmol/kg with and without pretreatment with 4 mmol/kg buthionine-[S,R]-sulfoximine (BSO), an inhibitor of GSH synthesis.
S, Aebi, B H, Lauterburg
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Biochimica et Biophysica Acta (BBA) - General Subjects, 1975
1. Two automated colorimetric methods have been developed for assaying the GSH and total thiol in protein-free extracts of erythrocytes. They employ as chromogens 5,5'-dithiobis-(2-nitrobenzoate) (DTNB) and alloxan. 2. The concentrations of GSH, GSSG and total non-protein thiol have been estimated in high and low GSH erythrocytes from Finnish Landrace ...
J D, Young, I A, Nimmo, J G, Hall
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1. Two automated colorimetric methods have been developed for assaying the GSH and total thiol in protein-free extracts of erythrocytes. They employ as chromogens 5,5'-dithiobis-(2-nitrobenzoate) (DTNB) and alloxan. 2. The concentrations of GSH, GSSG and total non-protein thiol have been estimated in high and low GSH erythrocytes from Finnish Landrace ...
J D, Young, I A, Nimmo, J G, Hall
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Archives of Pediatrics & Adolescent Medicine, 1968
To the Editor .—Recently Krasner and Yaffe 1 reported observations on the development of GSH aryl-transferase activity in mouse liver during the neonatal period. They also tried to enhance such enzymatic activity in the newborn mouse by injecting phenobarbital and substrate (sulfobromophthalein [BSP]) into the mother at the end of the pregnancy ...
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To the Editor .—Recently Krasner and Yaffe 1 reported observations on the development of GSH aryl-transferase activity in mouse liver during the neonatal period. They also tried to enhance such enzymatic activity in the newborn mouse by injecting phenobarbital and substrate (sulfobromophthalein [BSP]) into the mother at the end of the pregnancy ...
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Xenobiotic Detoxification by GSH-Loaded Erythrocytes
1992It is well known that the cells of higher organisms are able to excrete unwanted foreign chemicals (pesticides, herbicides, aromatic amines used in the dye industries, etc.) after metabolic conversion. An important role in this process is performed by reduced glutathione (GSH) which is present at high concentrations (2mM) in all living cells.
A. FAZI +4 more
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GSH transporters: molecular characterization and role in GSH homeostasis.
Biological chemistry Hoppe-Seyler, 1996Considerable progress has been made in the last few years in the molecular identification and characterization of hepatic GSH transporter-associated polypeptides. We are now poised to determine their precise mechanisms of action and regulation at the transcriptional and post-translational level. It is also anticipated that molecular characterization of
N, Kaplowitz +5 more
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2010
Loss of dopaminergic neurons, oxidative stress, deficient bioenergetics and decreased levels of reduced glutathione (GSH) in the substantia nigra are biochemical hallmarks of idiopathic Parkinson’s disease (PD). The intent of this study was to test the hypothesis that disturbances in GSH and dopamine (DA) homeostasis are detrimental to dopaminergic ...
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Loss of dopaminergic neurons, oxidative stress, deficient bioenergetics and decreased levels of reduced glutathione (GSH) in the substantia nigra are biochemical hallmarks of idiopathic Parkinson’s disease (PD). The intent of this study was to test the hypothesis that disturbances in GSH and dopamine (DA) homeostasis are detrimental to dopaminergic ...
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