Results 161 to 170 of about 121,769 (336)

In Silico Assessment of GSK-3? Inhibition Activity by Secondary Metabolites of Centella asiatica in the Development of Alzheimer’s Therapy

Journal of Tropical Pharmacy and Chemistry
Alzheimer’s disease involves excessive activity of glycogen synthase kinase-3? (GSK-3?), leading to tau hyperphosphorylation and neurofibrillary tangle formation.
Wiwin Azariani, Agus Dwi Ananto, Selvira Anandia Intan Maulidya   +2 more
doaj   +1 more source

Gsk-3-Mediated Proteasomal Degradation of ATF4 Is a Proapoptotic Mechanism in Mouse Pancreatic β-Cells. [PDF]

Int J Mol Sci, 2022
Nagao Y, Amo-Shiinoki K, Nakabayashi H, Hatanaka M, Kondo M, Matsunaga K, Emoto M, Okuya S, Tanizawa Y, Tanabe K.   +9 more
europepmc   +1 more source

Protective Effect of Minocycline Against Ketamine-Induced Injury in Neural Stem Cell: Involvement of PI3K/Akt and Gsk-3 Beta Pathway [PDF]

, 2016
Yang Lu, Shan Lei, Ning Wang, Pan Lu, Weisong Li, Juan Zheng, Praveen Kumar Giri, Haixia Lü, Xinlin Chen, Zhiyi Zuo, Yong Liu, Pengbo Zhang   +11 more
openalex   +1 more source

Regulation of GSK-3 [PDF]

Cell, 2001
openaire   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

The budding yeast GSK-3 homologue Mck1 is an essential component of the spindle position checkpoint. [PDF]

Open Biol, 2022
Rathi S, Polat I, Pereira G.
europepmc   +1 more source

9-Cyano-1-azapaullone (Cazpaullone), a Glycogen Synthase Kinase-3 (GSK-3) Inhibitor Activating Pancreatic β Cell Protection and Replication

, 2008
Hendrik Stukenbrock, Rainer Mußmann, Marcus Geese, Yoan Ferandin, Olivier Lozach, Thomas Lemcke, Simone Kegel, Alexander Lomow, Ulrike Burk, Cord Dohrmann, Laurent Meijer, Matthias Austen, Conrad Kunick   +12 more
openalex   +1 more source

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet, Anna Largajolli, Petra M. Jauslin, Emilie Schindler, Mourad Hamimed, Wannee Kantasiripitak, Antonio Gonçalves, Eline Van Maanen, Khaled Benkali, Tomohisa Saito, Jonathan I. Silverberg, Andreas Wollenberg, Michael Graeber, Liliana Ulianov, Christophe Piketty, Luca Loprete, Vincent Duval, Nathalie Wagner   +17 more
wiley   +1 more source

Real-world patient characteristics and survival outcomes in patients with advanced or recurrent endometrial cancer in England: a retrospective, population-based study

BMJ Open
Objective This study defined a retrospective cohort of patients in England with primary advanced or recurrent (A/R) endometrial cancer (EC) who may have been eligible for clinical trials evaluating immune checkpoint inhibitors (ICIs) in the first-line ...
Clare Pearson, Susana Banerjee, Kiera Heffernan, Tameera Rahman, Jamie Garside, Alvaro Ingles Russo Garces   +5 more
doaj   +1 more source

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation [PDF]

, 2003
Lilia Topol, Xueyuan Jiang, Hosoon Choi, Lisa Garrett‐Beal, Peter J. Carolan, Yingzi Yang   +5 more
openalex   +1 more source