Results 211 to 220 of about 106,875 (237)

Analysis of C4 Concentrations to Predict Impact of Patient‐Reported Diarrhea Associated With the Ileal Bile Acid Transporter Inhibitor Linerixibat

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 596-605, March 2025.
ABSTRACT Linerixibat, an ileal bile acid transporter (IBAT) inhibitor, is being evaluated for the treatment of pruritus in primary biliary cholangitis (PBC). Diarrhea is commonly reported with this drug class as IBAT inhibition redirects bile acids (BA) to the colon.
Fernando Carreño, Rashmi Mehta, Andrea Ribeiro de Souza, Jon Collins, Brandon Swift   +4 more
wiley   +1 more source

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

Body Composition and Muscle Function in Bronchiectasis: A Comparative Longitudinal Study

Respirology, EarlyView.
We compared body composition and muscle function in adults with bronchiectasis versus controls and assessed if leg strength estimates 1‐year outcomes. Patients with bronchiectasis had lower muscle mass, bone density, and leg strength. Reduced leg strength is associated with worse dyspnoea, quality of life, and functional capacity, highlighting the need
Joice Mara de Oliveira, Amber Smith, Paola D. Urroz Guerrero, Laura Cordova Rivera, Dennis Thomas, Vanessa L. Clark, Peter G. Gibson, Vanessa M. McDonald   +7 more
wiley   +1 more source

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

Dopamine: The Essential Bridge Mediating Obstructive Sleep Apnea and Hippocampus‐Dependent Learning and Memory Impairments

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Obstructive sleep apnea is a clinical syndrome that triggers a series of pathophysiologic changes, including disturbed sleep architecture, chronic intermittent hypoxia and hypercapnia, and ultimately severe cognitive dysfunction. The hippocampus plays a key role in various cognitive processes such as learning and memory.
Rui Fan, Tao Li, Yan Yan
wiley   +1 more source

Evaluation of the Quality and Suitability of Self‐Collected Vaginal and Urine Samples for Human Papillomavirus Testing: A Prospective Matched Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To evaluate the analytical suitability of different storage and laboratory processes of self‐samples for an HPV assay. Design Prospective matched study. Setting Royal London Hospital Colposcopy Clinic. Population One hundred seventy seven patients aged 25–65 years referred to colposcopy due to their screening results (abnormal ...
Kim Chu, Sofia Vidali, Anna Parberry, Michelle Saull, Krishna Patel, Hannah Mohy‐Eldin, Laura White, Adam Brentnall, Peter Sasieni, Rhian Gabe, Ranjit Manchanda, Jack Cuzick, Belinda Nedjai   +12 more
wiley   +1 more source

Risk of Cancer With Hormone Replacement Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Hormone replacement therapy (HRT) remains the cornerstone of menopausal symptom management, effectively alleviating vasomotor symptoms and genitourinary syndrome, whilst mitigating long‐term risks such as osteoporosis. However, despite an increasing body of evidence on the relative safety of HRT, earlier studies that demonstrated an increased ...
Gabriella Yongue, Zachary Nash, Vikram Talaulikar, Shibani Nicum   +3 more
wiley   +1 more source

Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer. [PDF]

Acta Pharm Sin B
Fu R, Dou Z, Li N, Fan X, Amin S, Zhang J, Wang Y, Li Z, Li Z, Yang P.   +9 more
europepmc   +1 more source

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Anti-inflammatory Potential of GSK-3 Inhibitors

Current Drug Targets, 2021
Glycogen synthase kinase-3 (GSK-3) is a protein kinase containing threonine or serine amino acid residues. GSK-3 was first discovered in 1980 as a regulatory protein kinase, Glycogen synthase (GS) enzyme, which is responsible for the conversion of glycogen from glucose with the help of uridine diphosphate glucose (UDP-Glu) residue.
Chandi C. Kandar, Debanjan Sen, Arindam Maity   +2 more
openaire   +2 more sources

GSK-3 Inhibitors: Discoveries and Developments

Current Medicinal Chemistry, 2004
Glycogen synthase kinase 3 (GSK-3) in the 21(st) century emerged as one of the most attractive therapeutic target for the development of selective inhibitors as new promising drugs for unmet pathologies including Alzheimer's disease, stroke, bipolar disorders, chronic inflammatory processes, cancer and diabetes type II.
M, Alonso, A, Martinez
openaire   +2 more sources