Results 11 to 20 of about 70,328 (289)

Macrophage GSK3β-deficiency inhibits the progression of hepatocellular carcinoma and enhances the sensitivity of anti-PD1 immunotherapy

Journal for ImmunoTherapy of Cancer, 2022
Background Glycogen synthase kinase 3β (GSK3β) was originally discovered to regulate glycogen synthesis and show a relationship to tumors. However, the biological functions of GSK3β in tumor-associated macrophages (TAMs) in cancers including ...
Li Liu, Jie Zhao, Jinyu Zhang, Guoqiang Sun, Yongxiang Xia, Xuehao Wang, Hanyuan Liu, Siqi Zhao, Zihao Zhang, Tian Huang, Xiangyi Kong, Weiwei Tang, Guangshun Sun, Hengsong Cao, Dawei Rong, Qinghua Ji   +15 more
doaj   +2 more sources

PGK1-coupled HSP90 stabilizes GSK3β expression to regulate the stemness of breast cancer stem cells

Cancer Biology & Medicine, 2022
Objective: Glycogen synthase kinase-3β (GSK3β) has been recognized as a suppressor of Wnt/β-catenin signaling, which is critical for the stemness maintenance of breast cancer stem cells.
Wei Tang, Yu Wu, Xin Qi, Rilei Yu, Zhimin Lu, Ao Chen, Xinglong Fan, Jing Li   +7 more
doaj   +2 more sources

The redox-sensitive GSK3β is a key regulator of glomerular podocyte injury in type 2 diabetic kidney disease

Redox Biology
Emerging evidence suggests that GSK3β, a redox-sensitive transducer downstream of insulin signaling, acts as a convergent point for myriad pathways implicated in kidney injury, repair, and regeneration.
Mengxuan Chen, Yudong Fang, Yan Ge, Shuhao Qiu, Lance Dworkin, Rujun Gong   +5 more
doaj   +2 more sources

Silmitasertib (CX-4945), a Clinically Used CK2-Kinase Inhibitor with Additional Effects on GSK3β and DYRK1A Kinases: A Structural Perspective

Journal of Medicinal Chemistry, 2023
A clinical casein kinase 2 inhibitor, CX-4945 (silmitasertib), shows significant affinity toward the DYRK1A and GSK3β kinases, involved in down syndrome phenotypes, Alzheimer’s disease, circadian clock regulation, and diabetes.
Przemysław Grygier, Katarzyna Pustelny, J. Nowak, Przemyslaw Golik, G. Popowicz, O. Plettenburg, G. Dubin, Filipe Menezes, A. Czarna   +8 more
semanticscholar   +1 more source

Hydrogen sulfide is neuroprotective in Alzheimer’s disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Alzheimer’s disease (AD) is the leading cause of dementia in the elderly. Although dysregulated hydrogen sulfide (H2S) metabolism has been reported in AD, and H2S donors are beneficial, molecular mechanisms underlying neuroprotective effects
Daniel Giovinazzo, Biljana Bursać, Juan I. Sbodio, Sumedha Nalluru, Thibaut Vignane, A. Snowman, Lauren M. Albacarys, T. Sedlak, R. Torregrossa, M. Whiteman, M. Filipović, S. Snyder, B. Paul   +12 more
semanticscholar   +1 more source

Molecular docking, molecular dynamics simulations and in vitro screening reveal cefixime and ceftriaxone as GSK3β covalent inhibitors

RSC Advances, 2023
GSK3β is a serine/threonine kinase that has been suggested as a putative drug target for several diseases. Recent studies have reported the beneficial effects of cephalosporin antibiotics in cancer and Alzheimer's disease, implying potential inhibition ...
Husam Nassar, W. Sippl, R. Dahab, M. Taha   +3 more
semanticscholar   +1 more source

Age-related GSK3β overexpression drives podocyte senescence and glomerular aging

Journal of Clinical Investigation, 2022
As life expectancy continues to increase, clinicians are challenged by age-related renal impairment that involves podocyte senescence and glomerulosclerosis.
Yudong Fang, Bohan Chen, Zhangsuo Liu, Athena Y. Gong, W. Gunning, Y. Ge, Deepak Malhotra, A. Gohara, L. Dworkin, R. Gong   +9 more
semanticscholar   +1 more source

Mouse mesenchymal stem cell-derived exosomal miR-466f-3p reverses EMT process through inhibiting AKT/GSK3β pathway via c-MET in radiation-induced lung injury

Journal of experimental & clinical cancer research : CR, 2022
Radiation-induced lung fibrosis (RILF) is a common complication of thoracic radiotherapy. Alveolar epithelial cells play a crucial role in lung fibrosis via epithelial-mesenchymal transition (EMT).
Yi Li, Zhufu Shen, X. Jiang, Yuanyuan Wang, Zuozhang Yang, Yuchi Mao, Zhi-li Wu, Gaofeng Li, Hong Chen   +8 more
semanticscholar   +1 more source

Nobiletin Induces Ferroptosis in Human Skin Melanoma Cells Through the GSK3β-Mediated Keap1/Nrf2/HO-1 Signalling Pathway

Frontiers in Genetics, 2022
Melanoma is an aggressive malignant skin tumour with an increasing global incidence. However, current treatments have limitations owing to the acquired tumour drug resistance.
Sen-ling Feng, Yong-qing Zhou, Hongliang Huang, Ying Lin, Yifeng Zeng, Shan‐Rui Han, Kai-kai Huang, Qu Liu, Wenting Zhu, Zhongwen Yuan, Bao-li Liang   +10 more
semanticscholar   +1 more source

Downregulation of microRNA‐6125 promotes colorectal cancer growth through YTHDF2‐dependent recognition of N6‐methyladenosine‐modified GSK3β

Clinical and Translational Medicine, 2021
Background MicroRNAs (miRNAs), the key regulator of gene expression, and N6‐methyladenosine (m6A) RNA modification play a significant role in tumour progression.
Hongyan Li, Ning Zhang, Xueli Jiao, Cong Wang, Wenchang Sun, Yanyun He, Ganglin Ren, Shirui Huang, Mengjie Li, Yixin Chang, Zihui Jin, Q. Xie, Xiaodong Zhang, Haishan Huang, Honglei Jin   +14 more
semanticscholar   +1 more source