Results 31 to 40 of about 46,501 (160)

MiR-27a-3p Targeting GSK3β Promotes Triple-Negative Breast Cancer Proliferation and Migration Through Wnt/β-Catenin Pathway

Cancer Management and Research, 2020
Ruizhen Wu, Bingqing Zhao, Xunxin Ren, Shiheng Wu, Mingzao Liu, Zipeng Wang, Wei Liu The First Affiliated Hospital, School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaCorrespondence: Wei LiuThe ...
Wu R, Zhao B, Ren X, Wu S, Liu M, Wang Z, Liu W   +6 more
doaj  

Additional file 1: of Hydrodynamic shear stress promotes epithelial-mesenchymal transition by downregulating ERK and GSK3β activities

, 2019
Table S1. Clinical characteristics of the patients with breast cancer in this study. (PDF 39 kb)
Choi, Hye, Yang, Gwang-Mo, Dayem, Ahmed, Saha, Subbroto, Kim, Kyeongseok, Yoo, Youngbum, Hong, Kwonho, Kim, Jin-Hoi, Yee, Cassian, Lee, Kyung-Mi, Cho, Ssang-Goo   +10 more
openaire   +1 more source

GSK3β phosphorylates NM1.

, 2014
(A) GSK3β, NM1 and actin are co-precipitated from nuclear protein extracts prepared from growing GSK3β+/+ MEFs. Bound proteins were detected on immunoblots with antibodies against WSTF, SNF2h, NM1, PCAF, GSK3β (CGR11) and actin. 10% of the input is shown
Anne Von Euler (573528), Piergiorgio Percipalle (393101), Laura Borgonovo-Brandter (573527), Neus Visa (245920), Douglas Lamont (573529), Bader Al-Muzzaini (393098), Martin Corcoran (573526), Aishe A. Sarshad (573525)   +7 more
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GSK3β overexpression indicates poor prognosis and its inhibition reduces cell proliferation and survival of non-small cell lung cancer cells. [PDF]

PLoS ONE, 2014
Glycogen synthase kinase 3 beta (GSK3β) is centrally involved in diverse cellular processes, including proliferation and apoptosis. This study aimed to investigate the influence of GSK3β expression on the prognosis of human non-small cell lung cancer ...
Jing Zeng, Dan Liu, Zhixin Qiu, Yi Huang, Bojiang Chen, Lei Wang, Huan Xu, Na Huang, Lunxu Liu, Weimin Li   +9 more
doaj   +1 more source

Additional file 7: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

, 2019
Figure S5. HMLE-vector and HMLE-Snail cells were treated with a dose range of the tested inhibitors, and viability was assessed by MTT assay. Of the drugs that were shortlisted from the screen, BIO was one of the drugs that could selectively inhibit HMLE-Snail cells with mesenchymal phenotype more efficiently as compared to HMLE-vector cells with ...
Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Joseph, Robiya, Pietila, Mika, Taube, Joseph, Sarkar, Tapasree, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Gao, Ruli, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Miura, Noayuki, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, Mani, Sendurai   +20 more
openaire   +1 more source

miR-135b targets GSK3β.

, 2014
(A) Schematic of predicted miR-135b site in the 3′UTR of GSK3β mRNA, which broadly conserved among vertebrates. (B) GSK3β expression was much lower in U87R cells compared to U87 cells at protein level and mRNA level by qRT-PCR and Western blot. (C) GSK3β
Songhua Xiao (322277), Qing Liu (20889), Zhen Yang (107412), Ming Wu (238132), Yiwei Liao (635768), Jia Zhao (511806), Ruiyan Lv (635767)   +6 more
core   +1 more source

Agrin promotes acetylcholine receptor clustering at the mammalian neuro-muscular junction by PI3K/GSK3ß²-mediated regulation of +TIPs and microtubule capture [PDF]

, 2013
Neurotransmission an der neuromuskulären Endplatte von Säugetieren erfolgt durch Ausschüttung von Acetylcholin (ACh) aus motorischen Nerven in den synaptischen Spalt und verursacht letztendlich Muskelkontraktion im angesteuerten Muskel.
Sladecek, Stefan
core   +1 more source

Inhibition of GSK 3β activity is associated with excessive EZH2 expression and enhanced tumour invasion in nasopharyngeal carcinoma. [PDF]

PLoS ONE, 2013
BACKGROUND:Enhancer of zeste homolog 2 (EZH2) has been shown to contribute to tumour development and/or progression. However, the signalling pathway underlying the regulation of EZH2 in nasopharyngeal carcinoma (NPC) remains unclear.
Renqiang Ma, Yi Wei, Xiaoming Huang, Ran Fu, Xi Luo, Xiaolin Zhu, Wenbin Lei, Jugao Fang, Huabin Li, Weiping Wen   +9 more
doaj   +1 more source

Additional file 3: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

, 2019
Figure S1. The IC50 of the 3 drugs were calculated for the 3 mesenchymal-like cell lines used in this study. (PDF 122â kb)
Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Joseph, Robiya, Pietila, Mika, Taube, Joseph, Sarkar, Tapasree, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Gao, Ruli, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Miura, Noayuki, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, Mani, Sendurai   +20 more
openaire   +1 more source

HYS-32 modulates GSK3β phosphorylation.

, 2015
(A) Cell lysates from control astrocytes (Con) or astrocytes treated for 2, 6, 12, or 24 h with 5 μM HYS-32 were subjected to 10% SDS-PAGE, and analyzed by immunoblotting with antibodies against GSK3β-pTyr216, GSK3β-pSer9, or GAPDH.
Guey-Mei Jow (149815), Chi-Ting Chiu (734340), Tswen-Kei Tang (734341), Hwai-Shi Wang (479606), Chih-Kai Liao (483917), Jiahn-Chun Wu (483918), Chien-Chang Shen (723352)   +6 more
core   +1 more source