Results 51 to 60 of about 46,501 (160)

IBAT phosphorylated GSK3β Ser9 (pGSK3β) and total GSK3β protein expression from offspring of 1000 mGy irradiated and Sham-irradiated dams.

, 2020
(A) Female offspring pGSK3β and total GSK3β protein expression. Below is the ratio of pGSK3β to total GSK3β. (B) Male offspring pGSK3β and total GSK3β protein expression. Black bars represent the phosphorylation of GSK3β. White bars represent total GSK3β
Alyssa Murray (7344980), Neelam Khaper (568115), Douglas R. Boreham (8356557), T. C. Tai (7344986), Caitlund Q. Davidson (8741589), Sujeenthar Tharmalingam (6277955), Simon J. Lees (8741592), Sarah Niccoli (539690), Sandhya Khurana (7339613), Ashley Nemec-Bakk (4259299)   +9 more
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Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3β

Mediators of Inflammation, 2020
Isoorientin has anti-inflammatory effects; however, the mechanism remains unclear. We previously found isoorientin is an inhibitor of glycogen synthase kinase 3β (GSK3β) in vitro. Overactivation of GSK3β is associated with inflammatory responses.
Yingui Li, Yijing Zhao, Xiaoqin Tan, Jiayan Liu, Yingkun Zhi, Lang Yi, Shasha Bai, Qun Du, Qing X. Li, Yan Dong   +9 more
doaj   +1 more source

Mammalian eIF4E2-GSK3β maintains basal phosphorylation of p53 to resist senescence under hypoxia

Cell Death and Disease, 2022
Hypoxia modulates senescence, but their physiological link remains unclear. Here, we found that eIF4E2, a hypoxia-activated translation initiation factor, interacted with GSK3β to maintain phosphorylation of p53, thus resisting senescence under hypoxia ...
Lei Sun, He Yang, Dong He, Jian Chen, Zhiqiang Dong, Shaoxiang Luo, Huiting Liang, Yu Cao, Bingcheng Cai, Min Zhang   +9 more
doaj   +1 more source

Macrophage GSK3β-deficiency inhibits the progression of hepatocellular carcinoma and enhances the sensitivity of anti-PD1 immunotherapy

Journal for ImmunoTherapy of Cancer, 2022
Background Glycogen synthase kinase 3β (GSK3β) was originally discovered to regulate glycogen synthesis and show a relationship to tumors. However, the biological functions of GSK3β in tumor-associated macrophages (TAMs) in cancers including ...
Li Liu, Jie Zhao, Jinyu Zhang, Guoqiang Sun, Yongxiang Xia, Xuehao Wang, Hanyuan Liu, Siqi Zhao, Zihao Zhang, Tian Huang, Xiangyi Kong, Weiwei Tang, Guangshun Sun, Hengsong Cao, Dawei Rong, Qinghua Ji   +15 more
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Additional file 3: Tables and Methods. of Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways

, 2017
Table S1, shRNA Sequences; Table S2, antibodies for immunoblot; Table S3, antibodies for immunofluorescence; Table S4, correlations between CXCL5 expression and clinical characteristics in CRC patients; Table S5, univariate and multivariate analyses of CXCL5 expression in CRC patients; Table S6, pathological stages of patients in Fig.
Zhao, Jingkun, Ou, Baochi, Han, Dingpei, Wang, Puxiongzhi, Zong, Yaping, Zhu, Congcong, Liu, Di, Zheng, Minhua, Sun, Jing, Feng, Hao, Lu, Aiguo   +10 more
openaire   +1 more source

Neural death in GSK3β mice.

, 2013
(A) dDG representative image of fractin positive cells (arrows) from GSK3β mice. DAPI staining in red is also shown. (B) Quantification of the number of fractin positive neurons in dDG and vDG from wt (n = 9) and GSK3β mice (n = 11).
Jesús Ávila (5652766), Almudena Fuster-Matanzo (340305), María Llorens-Martín (194343), Félix Hernández (81418), Elena Gómez de Barreda (340306)   +4 more
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GSK3β activity alleviates epileptogenesis and limits GluA1 phosphorylation [PDF]

, 2019
BACKGROUND: Glycogen synthase kinase-3β (GSK3β) is a key regulator of cellular homeostasis. In neurons, GSK3β contributes to the control of neuronal transmission and plasticity, but its role in epilepsy remains to be defined.
Devijver, H., Urbanska, M., Kotulska, Katarzyna, Krzysztof Sadowski, Jaworski, Jacek, Jozwiak, Sergiusz, Jaworski, J., Barbara Pijet, Pijet, Barbara, Devijver, Herman, Van Leuven, F., Fred Van Leuven, Eleonora Aronica, Karolina Nader, van Vliet, Erwin A., Katarzyna Kalita, Konopacki, J., Urbanska, Malgorzata, Jaworski, Tomasz, Sergiusz Jozwiak, Lechat, Benoit, Wieslawa Grajkowska, Jacek Jaworski, Bartosz Caban, van Vliet, E.A., Kowalczyk, Tomasz, Grajkowska, Wieslawa, van Vliet, E.A.; id_orcid, Jozwiak, S., Malgorzata Urbanska, Katarzyna Kotulska, Gozdz, A., Nader, Karolina, Sadowski, K., Konopacki, Jan, Sadowski, Krzysztof, Nader, K., Tomasz Jaworski, Kowalczyk, T., Caban, Bartosz, van Leuven, Fred, Jan Konopacki, Pijet, B., Grajkowska, W., Erwin A. van Vliet, Gozdz, Agata, Aronica, E., Benoit Lechat, Kotulska, K., Kalita, K., Jaworski, T., Aronica, Eleonora, Paulina Kazmierska-Grebowska, Tomasz Kowalczyk, Lechat, B., Caban, B., Kazmierska-Grebowska, P., Agata Gozdz, Kalita, Katarzyna, Herman Devijver, Kazmierska-Grebowska, Paulina   +60 more
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Higher proportion of inactive Gsk3β in platelets of elderly patients with bipolar disorder: an effect of treatment?

Brazilian Journal of Psychiatry, 2013
Objective: It has been postulated that mood stabilizers inhibit glycogen synthase kinase 3-beta (Gsk3β) activity, mainly through its phosphorylation on serine-9 (Ser9).
Rodolfo Braga Ladeira, Helena Passarelli Giroud Joaquim, Leda Leme Talib, Paula Villela Nunes, Orestes Vicente Forlenza   +4 more
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GSK3β Regulates Milk Synthesis in and Proliferation of Dairy Cow Mammary Epithelial Cells via the mTOR/S6K1 Signaling Pathway

Molecules, 2014
Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase, whose activity is inhibited by AKT phosphorylation. This inhibitory phosphorylation of GSK3β can in turn play a regulatory role through phosphorylation of several proteins (such as mTOR ...
Xia Zhang, Feng Zhao, Yu Si, Yuling Huang, Cuiping Yu, Chaochao Luo, Na Zhang, Qingzhang Li, Xuejun Gao   +8 more
doaj   +1 more source

USF2 is phosphorylated by GSK3β.

, 2014
(A) USF2 was immunoprecipitated from GSK3β+/+ and GSK3β−/− cells and phospho-USF2 protein levels were detected with phospho-threonine or phospho-serine antibodies.
Claudia Götz (631927), André H. Juffer (631929), Tabughang Franklin Chi (631926), Elitsa Y. Dimova (631930), Tina Horbach (631925), Satyan Sharma (631928), Thomas Kietzmann (631931)   +6 more
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