Results 61 to 70 of about 46,501 (160)
Indian Journal of OphthalmologyPurpose: This study was designed to investigate the primary targets and possible mechanisms of ranitidine (Ra) against diabetic retinopathy (DR). Methods: Single-cell sequencing technology and the SPIED3 platform were employed to characterize key genes ...
Wei He +3 more
doaj +1 more source
GSK3β inhibition affects barrier function.
, 2013 (A) Trans-Endothelial Electrical Resistance (TEER) was measured continuously in primary human brain microvascular endothelial cells (BMVEC) with or without GSK3β inhibitors LiCl (10 mM) and SB216763 (20 µM). After baseline TEER was achieved (between 7–10
Larisa Gofman (283792) +7 more
core +1 more source
Expression of NKD1 in cervical cancer and its clinical significance
徐州医科大学学报Objective To investigate the expression of NKD1 in cervical cancer tissues, its effects on the proliferation and migration of cervical cancer cells, and the underlying molecular mechanisms. Methods Cervical tissue specimens were obtained through surgical
PEI Wanqiu, JING Li, LI Yijuan
doaj +1 more source
GSK3β regulates pol I transcription activation.
, 2014 (A) rRNA synthesis in GSK3β+/+ MEFs and GSK3β−/− MEFs. For the analysis, relative 45S pre-rRNA levels were monitored from total RNA preparations by RT–qPCR using actin mRNA as internal control.
Anne Von Euler (573528) +7 more
core +1 more source
Frontiers in Behavioral Neuroscience, 2015 Attempts have been made to use glycogen synthase kinase-3 beta (GSK3β) inhibitors for prophylactic treatment of neurocognitive conditions. However the use of lithium, a non-specific inhibitor of GSK3β results in mild cognitive impairment in humans.
Benjamin eChew +10 more
doaj +1 more source
Dysfunction of GSK3β disrupts ciliogenesis.
, 2015 (A) Schematic model of the acquisition of synchronized mitosis–G0 phase NIH 3T3 cells, treated with double thymidine block, nocodazole (Noc), and the indicated GSK3 inhibitors. (B and C) Inhibition of GSK3 impairs ciliogenesis.
Tingting Zhang (264633) +6 more
core +1 more source
S-SCAM inhibits Axin-dependent synaptic function of GSK3β in a sex-dependent manner
Scientific Reports, 2022 S-SCAM/MAGI-2 gene duplication is associated with schizophrenia (SCZ). S-SCAM overexpression in the forebrain induces SCZ-like phenotypes in a transgenic (Tg) mouse model.
Gillian Kearney +4 more
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The role of the Bmi1-GSK3β pathway in glioblastoma
, 2010 Malignant gliomas remain one of the deadliest of all cancers despite maximal therapy. They present unique challenges to therapy with a median survival of 12 months. Simultaneous activation of several growth promoting and anti-apoptotic pathways represents the basis for the failure of monotherapies against this disease. In order to efficiently block
openaire +2 more sources
GSK3β regulates osteoblast differentiation in ADSCs of transgenic mice expressing GSK3β mutants.
, 2013 (A) Immunoblot analysis to detect transgene expression in ADSCs purified from the adipose tissues of C57BL/6 mice expressing a transgene (TG) encoding HA-tagged GSK3β or wild-type littermates. As in Fig.
Soo Young Lee (104705) +3 more
core +1 more source
Cell Death and Disease, 2022 NOTCH1 alterations have been associated with chronic lymphocytic leukemia (CLL), but the molecular mechanisms underlying NOTCH1 activation in CLL cells are not completely understood.
Filomena De Falco +14 more
doaj +1 more source