Results 11 to 20 of about 46,501 (160)

GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons. [PDF]

PLoS ONE, 2015
The PI3K-dependent activation of AKT results in the inhibition of GSK3β in most signaling pathways. These kinases regulate multiple neuronal processes including the control of synapse number as shown for Drosophila and rodents.
Germán Cuesto, Sheila Jordán-Álvarez, Lilian Enriquez-Barreto, Alberto Ferrús, Miguel Morales, Ángel Acebes   +5 more
doaj   +3 more sources

GSK3β Inhibition Ameliorates Atherosclerotic Calcification. [PDF]

, 2023
Endothelial-mesenchymal transition (EndMT) drives endothelium to contribute to atherosclerotic calcification. In a previous study, we showed that glycogen synthase kinase-3β (GSK3β) inhibition induced β-catenin and reduced mothers against DPP homolog 1 ...
Yao, Yucheng, Xinjiang Cai, Boström, Kristina, Zhang, Li, Xiuju Wu, Yang, Yang, Yucheng Yao, Li Zhang, Jaden Ji, Yan Zhao, Jocelyn A. Ma, Ma, Jocelyn, Ji, Jaden, Yang Yang, Kristina I. Boström, Cai, Xinjiang, Zhao, Yan, Wu, Xiuju   +17 more
core   +1 more source

Role of morphogenic proteins of the WNT signaling pathway in coronary artery disease

Медицинская иммунология, 2023
In recent years, researchers’ attention has been directed to the WNT signaling pathway study, which regulates embryogenesis processes and is involved in pathological condition development.
I. A. Snimshchikova, M. O. Plotnikova
doaj   +1 more source

Intrarenal and Urinary Glycogen Synthase Kinase-3 Beta Levels in Diabetic and Nondiabetic Chronic Kidney Disease

Kidney & Blood Pressure Research, 2023
Background: Renal glycogen synthase kinase-3 beta (GSK3β) overactivity has been associated with a diverse range of kidney diseases. GSK3β activity in urinary exfoliated cells was reported to predict the progression of diabetic kidney disease (DKD).
Lingfeng Zeng, Jack Kit-Chung Ng, Winston Wing-Shing Fung, Gordon Chun-Kau Chan, Kai-Ming Chow, Cheuk-Chun Szeto   +5 more
doaj   +1 more source

Inhibition of GSK3β Reduces Ectopic Lipid Accumulation and Induces Autophagy by the AMPK Pathway in Goat Muscle Satellite Cells

Cells, 2019
Ectopic lipid accumulation in muscle is important not only for obesity and myopathy treatment, but also for meat quality improvement in farm animals.
Linjie Wang, Xin Liu, Siyuan Zhan, Jiazhong Guo, Shizhong Yang, Tao Zhong, Li Li, Hongping Zhang, Yan Wang   +8 more
doaj   +1 more source

The Effect of Uphill and Downhill Exercise Training on Myogenic Mechanism of Wnt/BMP Signaling in the Skeletal Muscle of Aged Rats [PDF]

운동과학, 2019
PURPOSE The purpose of this study was to determine the effect of exercise types on the Wnt/BMP signaling and the response to myogenic mechanism by downhill and uphill training in the aged rat skeletal muscles.
Yong-Uoo Chang, Jeong-Seok Kim
doaj   +1 more source

Supplementary Figure S1. Densitometric analysis of total β-catenin, active β-catenin, AurKA, p-AktSer473, p-GSK3βSer9 and p-Mcl-1Ser159 expression. from Loss of PKCδ Induces Prostate Cancer Resistance to Paclitaxel through Activation of Wnt/β-Catenin Pathway and Mcl-1 Accumulation

, 2023
<p>PKCÎ'-silenced PC3 (a) and LNCaP (b) cells were treated with DMSO or paclitaxel 2.5 µM 48 hours. Histograms show densitometric and statistical analysis of indicated proteins from panels (c) and (d) of the Figure 3. Data are presented as mean{plus minus}S.E.M.
Carmen Sáez, Miguel A. Japón, Francisco Romero, Begoña Pérez-Valderrama, Rafael Medina, Jessica Gasca, Carolina Castilla, M. Luz Flores   +7 more
openaire   +1 more source

The Effect of Type 2 Diabetes Mellitus on the Development of Alzheimer’s Disease and Its Molecular Mechanism

Bezmiâlem Science, 2022
Following increased epidemiological studies indicating the relationship between diabetes and Alzheimer’s disease (AD), Type 2 diabetes has been reported to be a risk factor for the progress of AD pathology.
Rabia DURAN, Sümeyra PANCUR, Fatemeh BAHADORİ   +2 more
doaj   +1 more source

SHP2 promotes proliferation of breast cancer cells through regulating Cyclin D1 stability via the PI3K/AKT/GSK3β signaling pathway

Cancer Biology & Medicine, 2020
Objective: The tyrosine phosphatase SHP2 has a dual role in cancer initiation and progression in a tissue type-dependent manner. Several studies have linked SHP2 to the aggressive behavior of breast cancer cells and poorer outcomes in people with cancer.
Yue Yuan*, Yanling Fan*, Zicong Gao, Xuan Sun, He Zhang, Zhiyong Wang, Yanfen Cui, Weijie Song, Zhaosong Wang, Fei Zhang, Ruifang Niu   +10 more
doaj   +1 more source

Assessing the Role of GSK3 β and Arrestin Beta1 in Regulating Oxidative Stress that Causes Metabolic Disorders [PDF]

Kirkuk Journal of Science
Metabolic syndrome is intricately associated with diabetes and obesity. Elevated obesity fosters inflammation and oxidative stress, which are precursors to several problems, including elements of metabolic disorders such as insulin resistance and hyper ...
Asmaa Abd, Fayhaa Khaleel
doaj   +1 more source