Results 21 to 30 of about 46,501 (160)

Hair growth potential of Salvia plebeia extract and its associated mechanisms

Pharmaceutical Biology, 2020
Context Although Salvia plebeia (SP) R. Brown (Labiatae) is known to possess various biological activities, the effects of SP on hair growth have not been elucidated.
Guang-Ri Jin, Yi-Lin Zhang, Jonathan Yap, William A. Boisvert, Bog-Hieu Lee   +4 more
doaj   +1 more source

The Axin scaffold protects the kinase GSK3β from cross-pathway inhibition

eLife, 2023
Multiple signaling pathways regulate the kinase GSK3β by inhibitory phosphorylation at Ser9, which then occupies the GSK3β priming pocket and blocks substrate binding.
Maire Gavagan, Noel Jameson, Jesse G Zalatan   +2 more
doaj   +1 more source

Glycogen synthase kinase 3β promotes osteogenic differentiation of murine adipose-derived stromal cells. [PDF]

PLoS ONE, 2013
Although the role of glycogen synthase kinase 3β (GSK3β) in osteogenic differentiation of bone marrow-derived mesenchymal stromal cells (BMSCs) is well-characterized as a negative regulator of β-catenin, its effect on osteogenesis of adipose-derived ...
Jeong-Eun Huh, Ryeojin Ko, Hyun Ju Jung, Soo Young Lee   +3 more
doaj   +1 more source

PGK1-coupled HSP90 stabilizes GSK3β expression to regulate the stemness of breast cancer stem cells

Cancer Biology & Medicine, 2022
Objective: Glycogen synthase kinase-3β (GSK3β) has been recognized as a suppressor of Wnt/β-catenin signaling, which is critical for the stemness maintenance of breast cancer stem cells.
Wei Tang, Yu Wu, Xin Qi, Rilei Yu, Zhimin Lu, Ao Chen, Xinglong Fan, Jing Li   +7 more
doaj   +1 more source

Methyleugenol protects against t-BHP-triggered oxidative injury by induction of Nrf2 dependent on AMPK/GSK3β and ERK activation

Journal of Pharmacological Sciences, 2017
Methyleugenol (Mlg), a natural ingredient of many herbs and used as a flavoring substance in dietary products, inhibits inflammation and oxidative stress. The aim of the study is to explore the antioxidative potential of Mlg against tert-butyl hydroperoxide (t-BHP)-triggered oxidative injury and the involvement of antioxidative mechanisms. Our findings
Junfeng Zhou, Xiaoyuan Ma, Yan Cui, Yang Song, Lei Yao, Yuanyuan Liu, Shanshan Li   +6 more
openaire   +3 more sources

Constitutively active GSK3β as a means to bolster dendritic cell functionality in the face of tumour-mediated immune suppression

OncoImmunology, 2019
In patients with cancer, the functionality of Dendritic Cells (DC) is hampered by high levels of tumor-derived suppressive cytokines, which interfere with DC development and maturation.
Marta López González, Dinja Oosterhoff, Jelle J. Lindenberg, Ioanna Milenova, Sinead M. Lougheed, Tania Martiáñez, Henk Dekker, Dafne Carolina Alves Quixabeira, Basav Hangalapura, Jos Joore, Sander R. Piersma, Victor Cervera-Carrascon, Joao Manuel Santos, Rik J. Scheper, Henk M.W. Verheul, Connie R. Jiménez, Rieneke Van De Ven, Akseli Hemminki, Victor W. Van Beusechem, Tanja D. De Gruijl   +19 more
doaj   +1 more source

Proteomic characterization of GSK3β knockout shows altered cell adhesion and metabolic pathway utilisation in colorectal cancer cells

PLoS ONE, 2021
Glycogen-specific kinase (GSK3β) is an integral regulator of the Wnt signalling pathway as well as many other diverse signalling pathways and processes.
Emily Bowler-Barnett, Francisco D. Martinez-Garcia, Matthew Sherwood, Ahood Aleidan, Steve John, Sara Weston, Yihua Wang, Nullin Divecha, Paul Skipp, Rob M. Ewing   +9 more
doaj   +2 more sources

Notch3 Transactivates Glycogen Synthase Kinase-3-Beta and Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer Cells

Cells, 2022
As a critical transformational process in the attributes of epithelial cells, epithelial-to-mesenchymal transition (EMT) is involved in tumor invasion, metastasis, and resistance to treatment, which contributes to the ultimate death of some patients with
Weiling Chen, Yongqu Zhang, Ronghui Li, Wenhe Huang, Xiaolong Wei, De Zeng, Yuanke Liang, Yunzhu Zeng, Min Chen, Lixin Zhang, Wenliang Gao, Yuanyuan Zhu, Yaochen Li, Guojun Zhang   +13 more
doaj   +1 more source

Additional file 2: of Hydrodynamic shear stress promotes epithelial-mesenchymal transition by downregulating ERK and GSK3β activities

, 2019
Table S2. Sequences of the primers used in this study. (PDF 20 kb)
Choi, Hye, Yang, Gwang-Mo, Dayem, Ahmed, Saha, Subbroto, Kim, Kyeongseok, Yoo, Youngbum, Hong, Kwonho, Kim, Jin-Hoi, Yee, Cassian, Lee, Kyung-Mi, Cho, Ssang-Goo   +10 more
openaire   +1 more source

GSK3β phosphorylates Dzip1.

, 2015
(A and B) Dzip1 interacts with GSK3β. Endogenous GSK3β was immunoprecipitated by Dzip1 but not IgG (A), and endogenous Dzip1 was immunoprecipitated with GFP-GSK3β in HEK 293T cells (B). (C and D) Dzip1 is co-localized with GSK3β at the basal body.
Tingting Zhang (264633), Qing Jiang (197843), Guopeng Wang (720360), Chuanmao Zhang (163797), Boyan Zhang (501940), Wangfei Chi (720361), Gang Wang (36685)   +6 more
core   +1 more source