Results 61 to 70 of about 70,328 (289)

Notch3 Transactivates Glycogen Synthase Kinase-3-Beta and Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer Cells

open access: yesCells, 2022
As a critical transformational process in the attributes of epithelial cells, epithelial-to-mesenchymal transition (EMT) is involved in tumor invasion, metastasis, and resistance to treatment, which contributes to the ultimate death of some patients with
Weiling Chen   +13 more
doaj   +1 more source

The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver [PDF]

open access: yes, 2019
Secreted frizzled-related protein (sFRP) 4 is an adipokine with increased expression in white adipose tissue from obese subjects with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).
Al-Hasani, Hadi   +12 more
core   +1 more source

Inhibition of Autophagy Signaling via 3-methyladenine Rescued Nicotine-Mediated Cardiac Pathological Effects and Heart Dysfunctions. [PDF]

open access: yes, 2020
Rationale: Cigarette smoking is a well-established risk factor for myocardial infarction and sudden cardiac death. The deleterious effects are mainly due to nicotine, but the mechanisms involved and theranostics remain unclear.
Fu, Yingjie   +7 more
core  

Overcoming steroid resistance in T cell acute lymphoblastic leukemia [PDF]

open access: yes, 2016
In a Perspective, Pieter Van Vlierberghe and Steven Goossens discuss Meijerink and colleagues' findings on steroid resistance in pediatric T cell acute lymphoblastic ...
Goossens, Steven   +1 more
core   +3 more sources

Additional file 1: of Hydrodynamic shear stress promotes epithelial-mesenchymal transition by downregulating ERK and GSK3β activities

open access: yes, 2019
Table S1. Clinical characteristics of the patients with breast cancer in this study. (PDF 39 kb)
Choi, Hye   +10 more
openaire   +1 more source

Targeting self-renewal pathways in myeloid malignancies [PDF]

open access: yes, 2013
A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through ...
Copland, M., Sands, W.A., Wheadon, H.
core   +2 more sources

MiR-27a-3p Targeting GSK3β Promotes Triple-Negative Breast Cancer Proliferation and Migration Through Wnt/β-Catenin Pathway

open access: yesCancer Management and Research, 2020
Ruizhen Wu, Bingqing Zhao, Xunxin Ren, Shiheng Wu, Mingzao Liu, Zipeng Wang, Wei Liu The First Affiliated Hospital, School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaCorrespondence: Wei LiuThe ...
Wu R   +6 more
doaj  

GSK3β overexpression indicates poor prognosis and its inhibition reduces cell proliferation and survival of non-small cell lung cancer cells. [PDF]

open access: yesPLoS ONE, 2014
Glycogen synthase kinase 3 beta (GSK3β) is centrally involved in diverse cellular processes, including proliferation and apoptosis. This study aimed to investigate the influence of GSK3β expression on the prognosis of human non-small cell lung cancer ...
Jing Zeng   +9 more
doaj   +1 more source

Glycogen Synthase Kinase 3β (GSK3β) Regulates Myogenic Differentiation in Skeletal Muscle Satellite Cells of Sheep

open access: yesAnimals, 2022
Glycogen synthase kinase 3β (GSK3β) has a vital role in the regulation of many cellular processes. However, the role of GSK3β in muscle cell differentiation in sheep remains unknown. In this study, we investigated the function of GSK3β in skeletal muscle
Jingquan Yang   +3 more
doaj   +1 more source

Additional file 2: of Hydrodynamic shear stress promotes epithelial-mesenchymal transition by downregulating ERK and GSK3β activities

open access: yes, 2019
Table S2. Sequences of the primers used in this study. (PDF 20 kb)
Choi, Hye   +10 more
openaire   +1 more source

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