Results 71 to 80 of about 70,328 (289)

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells [PDF]

, 2014
The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as protein kinase B) phosphorylates Ser(487) in the ‘ST loop’ (serine/threonine-rich loop) within the C-terminal domain of AMPK-α1 (AMP-activated protein kinase-α1),
Chen, Cross, D. Grahame Hardie, Dagon, Dale, Davidson, Davies, Davies, Decensi, Evans, Faubert, Fiona A. Ross, Fogarty, Frame, Goransson, Gowans, Graeme J. Gowans, Hardie, Hawley, Hawley, Hawley, Hawley, Hawley, Hawley, Hirai, Horman, Hurley, Hurley, Ji, Lee, Lizcano, Mankouri, Nicholas R. Leslie, Ning, Obata, Obenauer, Priyanka Tibarewal, Roach, Sanchez-Cespedes, Sanders, Scott, Shaw, Simon A. Hawley, Street, Suzuki, Towler, Wingo, Woods, Woods, Woods, Woods, Xiao, Xiao, Yuan   +53 more
core   +4 more sources

Permissive effect of GSK3β on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease

Cell Death and Disease, 2021
Renal tubular epithelial cells (TECs) play a key role in renal fibrogenesis. After persistent injuries that are beyond self-healing capacity, TECs will dedifferentiate, undergo growth arrest, convert to profibrogenic phenotypes, and resort to maladaptive
Bohan Chen, Pei Wang, Xianhui Liang, Chunming Jiang, Y. Ge, L. Dworkin, R. Gong   +6 more
semanticscholar   +1 more source

Inhibition of GSK 3β activity is associated with excessive EZH2 expression and enhanced tumour invasion in nasopharyngeal carcinoma. [PDF]

PLoS ONE, 2013
BACKGROUND:Enhancer of zeste homolog 2 (EZH2) has been shown to contribute to tumour development and/or progression. However, the signalling pathway underlying the regulation of EZH2 in nasopharyngeal carcinoma (NPC) remains unclear.
Renqiang Ma, Yi Wei, Xiaoming Huang, Ran Fu, Xi Luo, Xiaolin Zhu, Wenbin Lei, Jugao Fang, Huabin Li, Weiping Wen   +9 more
doaj   +1 more source

Additional file 3: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

, 2019
Figure S1. The IC50 of the 3 drugs were calculated for the 3 mesenchymal-like cell lines used in this study. (PDF 122â kb)
Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Joseph, Robiya, Pietila, Mika, Taube, Joseph, Sarkar, Tapasree, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Gao, Ruli, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Miura, Noayuki, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, Mani, Sendurai   +20 more
openaire   +1 more source

Absence of system xc⁻ on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis [PDF]

, 2017
Background: Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability.
A Banjac, A Castegna, A Chakrabarty, A Dasgupta, A Fogli, A Lau, A Martín, A Massie, A Massie, A Massie, A Mehta, A Prez-Samart¡n, A Tisell, A Vallejo-Illarramendi, AC Rimaniol, Ann Massie, AS Basso, Axel Methner, AY Shih, B Fogal, C Kilkenny, C Larochelle, C Matute, C Nathan, Cathy Jensen, D Bundel De, D Offen, D Piani, D Pitt, D Pitt, D Zhai, DA Baker, DA Hafler, E Merckx, EA McCullagh, Eduard Bentea, Ellen Merckx, F Loria, FN Soria, G Angelini, G Grasselli, G Sulkowski, G Sulkowski, GC Mc, Geert van Loo, Giulia Albertini, H Broholm, H Gmunder, H Hardin-Pouzet, H Sato, H Sato, H Sato, H Sato, H Sato, Hideyo Sato, I Gutcher, IE Morales Pantoja, IR Stojanovic, J Al-Omaishi, J Lewerenz, J Lewerenz, J Lewerenz, J Liefferinge Van, J Newcombe, JA Ellerhorst, Jacques De Keyser, Jan Lewerenz, JF Stover, JJ Geurts, JJ Hendriks, Joeri Van Liefferinge, K Mitosek-Szewczyk, KE Hill, KJ Smith, KS Evonuk, Lauren Deneyer, Lise Verbruggen, LM Sayre, M Kursar, M Naegele, M Ohgoh, M Penkowa, M Vercellino, Magdalena Paterka, Michael Dietrich, O Ciccarelli, O Maguire, O Pampliega, P Gadangi, P Maher, P Sarchielli, P Sarchielli, P Valk van der, P Werner, Pamela Maher, Philipp Albrecht, PW Gout, R Bridges, R Pacheco, R Srinivasan, RJ Bridges, S Bannai, S Chintala, S Licht-Mayer, T Smith, Thomas Demuyser, W Droge, Y Ganor, Y Gilgun-Sherki, Y He, Y He   +110 more
core   +2 more sources

Additional file 7: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

, 2019
Figure S5. HMLE-vector and HMLE-Snail cells were treated with a dose range of the tested inhibitors, and viability was assessed by MTT assay. Of the drugs that were shortlisted from the screen, BIO was one of the drugs that could selectively inhibit HMLE-Snail cells with mesenchymal phenotype more efficiently as compared to HMLE-vector cells with ...
Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Joseph, Robiya, Pietila, Mika, Taube, Joseph, Sarkar, Tapasree, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Gao, Ruli, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Miura, Noayuki, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, Mani, Sendurai   +20 more
openaire   +1 more source

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome [PDF]

, 2018
Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles.
Arena, Andrea, Barone, Eugenio, Blarzino, Carla, Butterfield, D. Allan, Di Domenico, Fabio, Lanzillotta, Chiara, Mosca, Luciana, Perluigi, Marzia, Tramutola, Antonella, Zuliani, Ilaria   +9 more
core   +3 more sources

Additional file 4: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

, 2019
Figure S2. The drugs that were selected from the screen were validated using FACS. The MDA MB 231 reporter cells were treated with all the 11 drugs selected from the screen. Following treatment, the percentage of cells fluorescing red and green were assessed using flow cytometry and plotted for each of the three concentrations to generate the graphs ...
Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Joseph, Robiya, Pietila, Mika, Taube, Joseph, Sarkar, Tapasree, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Gao, Ruli, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Miura, Noayuki, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, Mani, Sendurai   +20 more
openaire   +1 more source

Fear Conditioning and Extinction: Examining the Role of GSK3β ser 389 [PDF]

, 2016
GSK3β is a serine threonine kinase that has been shown to influence numerous biological and psychological interactions, including the regulation of cell survival and cell death, as well as influencing mood disorders such as major depressive disorder and ...
Liebman, Benjamin
core   +1 more source

Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1 [PDF]

, 2011
We describe the use of iterative in situ click chemistry to design an Akt-specific branched peptide triligand that is a drop-in replacement for monoclonal antibodies in multiple biochemical assays.
Agnew, Heather D., Deyle, Kaycie M., Heath, James R., Hein, Jason, Henning, Ryan K., Kwong, Gabriel A., Lee, Su Seong, Lim, Jaehong, Millward, Steven W., Nag, Arundhati, Pfeilsticker, Jessica A., Pitram, Suresh, Sharpless, K. Barry   +12 more
core   +2 more sources