Results 101 to 110 of about 190,941 (249)

Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug‐resistant epilepsy: From operating room to wet lab

Epilepsia Open, EarlyView.
Abstract Objective We have established a comprehensive sample handling protocol designed for the multiscale assessment of epileptogenic tissue. This protocol aims to identify novel therapeutic targets and enhance the diagnosis and stratification of patients with drug‐resistant epilepsy, thereby optimizing their treatment with anti‐seizure medications ...
Jenni Kyyriäinen, Adriana Della Pietra, Mastaneh Torkamani‐Azar, Mireia Gómez‐Budia, Polina Abushik, Nataliia Novosolova, Henri Eronen, Omar Narvaez, Ekaterina Paasonen, Vera Lezhneva, Anssi Pelkonen, Liudmila Saveleva, Antti Huotarinen, Ilya Belevich, Eija Jokitalo, Kuopio Epilepsy Center Epilepsy Surgery Group, Leena Jutila, Tuomas Rauramaa, Arto Immonen, Ville Leinonen, Jussi Tohka, Olli Gröhn, Reetta Kälviäinen, Tarja Malm, Alejandra Sierra   +24 more
wiley   +1 more source

In a concerted action kit ligand and interleukin 3 control the synthesis of serotonin in murine bone marrow-derived mast cells. Up-regulation of GTP cyclohydrolase I and tryptophan 5-monooxygenase activity by the kit ligand

, 1993
Irmgard Ziegler, Lothar Hültner, Denise Egger, Belinda Kempkes, R. Mailhammer, Steven Gillis, Wolfgang Rödl   +6 more
openalex   +1 more source

Protocol for the Preparation of Polyphenols‐Polysaccharide Nanoparticles

Food Chemistry International, EarlyView.
ABSTRACT Polyphenols, natural compounds abundantly distributed in plants, possess potent antioxidant and anti‐inflammatory activities and hold promising potential in cardiovascular protection and the management of metabolic disorders. Nevertheless, their intrinsic instability and low bioavailability severely constrain their practical and large‐scale ...
Chenxu Bao, Boqian He, Siyu Han, Jingying Liu, Jia Yan, Chunlin Li, Qian Wu   +6 more
wiley   +1 more source

Stimulation of adrenal mitochondrial cholesterol side-chain cleavage by GTP, steroidogenesis activator polypeptide (SAP), and sterol carrier protein2. GTP and SAP act synergistically.

, 1991
T S Xu, Edward P. Bowman, David B. Glass, J. David Lambeth   +3 more
openalex   +1 more source

Modification of GTP-activated calcium translocation by fatty acyl-CoA esters. Evidence for a GTP-induced prefusion event.

, 1994
Krystyna E. Rys‐Sikora, Tarun Kanti Ghosh, Donald L. Gill   +2 more
openalex   +1 more source

Characterization of cDNAs Encoding Small GTP-Binding Proteins from Maize [PDF]

, 1995
K. K. Kang, Hiroshi Sano, T. Kameya
openalex   +1 more source

Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction

iMeta, EarlyView.
The pervasiveness of microplastic pollution poses a growing health risk, yet its long‐term metabolic consequences remain poorly defined. Here, we exposed mice to polyethylene terephthalate nanoparticle (NP) and combined histopathology, biochemistry, metabolomics, and metagenomics to resolve their interactions.
Yi Zhang, Zheng Lin, Runtong Huang, Yang Zhang, Lei Wang, Zan Fu, Chao Wang, Shuai Xiao, Heru Pramono, Kui Xu, Zhimin Xu, Yulong Yin   +11 more
wiley   +1 more source

Artificial Intelligence‐Based Quantification to Assess the Automatic Psoriasis Area and Severity Index

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Psoriasis is a chronic inflammatory skin condition affecting millions globally, traditionally assessed via the Psoriasis Area and Severity Index (PASI). Despite its widespread use, PASI suffers from subjectivity, limited sensitivity for small lesions, and high interobserver variability.
Taig Mac Carthy, Daniel Dagnino, Alfonso Medela, Gerardo Fernández, Andy Aguilar, Antonio Martorell, Pedro Gómez‐Tejerina, Gastón Roustán‐Gullón   +7 more
wiley   +1 more source

Activity of 1,3-β-D-Glucan Synthase Requires the GTP-binding Protein Rho1 [PDF]

, 1996
Paul Mazur, Walter F. Baginsky
openalex   +1 more source

LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease

Movement Disorders, EarlyView.
Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang, Robert A. Hauser, Lorraine V. Kalia, Bonnie Hersh, Zdenek Berger, Roy Llorens Arenas, Coro Paisan‐Ruiz, Kyle Fraser, Danna Jennings, Jillian H. Kluss, Sarah Huntwork‐Rodriguez, Anastasia G. Henry, J. Timothy Greenamyre   +12 more
wiley   +1 more source