Results 111 to 120 of about 190,941 (249)

Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors

Medicinal Research Reviews, EarlyView.
ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara, Gómez‐Santacana Xavier, Llebaria Amadeu, Rovira Xavier   +3 more
wiley   +1 more source

Folate biofortification of lettuce by expression of a codon optimized chicken GTP cyclohydrolase I gene

, 2009
Aline Costa Santos Nunes, Danielle C. Kalkmann, F. J. L. Aragão   +2 more
openalex   +2 more sources

Extracellular Signal-regulated Kinase and the Small GTP-binding Protein, Rac, Contribute to the Effects of Transforming Growth Factor-β1 on Gene Expression [PDF]

, 1996
István Mucsi, Karl Skorecki, Howard Goldberg   +2 more
openalex   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Membrane tethering by the atlastin GTPase depends on GTP hydrolysis but not on forming the cross-over configuration

, 2014
Simran G. Saini, Chuang Liu, Peijun Zhang, Tina H. Lee   +3 more
openalex   +1 more source

Detection of Small GTP Binding Proteins Showing GTPase and GTP/ATP Binding Activities in the Ovary of the American Cockroach, Periplaneta Americana, during Oogenesis [PDF]

, 2014
Mohamed Elmogy
openalex   +1 more source

Recent Progress in Treating Airway Mucus Hypersecretion by Targeting the Epidermal Growth Factor Receptor Signaling Pathway

Pediatric Discovery, EarlyView.
ABSTRACT Asthma, chronic pulmonary obstructive disease (COPD), cystic fibrosis, and acute respiratory infections are severe respiratory conditions that significantly contribute to global morbidity and mortality. Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated ...
Yuanyuan Zhang, Fuping Yang, Chunyu Yan, Yu Deng, Enmei Liu   +4 more
wiley   +1 more source

Noncanonical Myo9b-RhoGAP Accelerates RhoA GTP Hydrolysis by a Dual-Arginine-Finger Mechanism

, 2016
Feng‐Shuang Yi, Ruirui Kong, Jinqi Ren, Li Zhu, Jizhong Lou, Jane Y. Wu, Wei Feng   +6 more
openalex   +1 more source

Secretion of 5‐hydroxytryptamine from electropermeabilised human platelets Effects of GTP and cyclic 3′, 5′‐AMP [PDF]

, 1987
D. E. Knight, M.C. Scrutton
openalex   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source