Cellular Physiology and Biochemistry, 2014 Background/Aims: Extracellular GTP is able to modulate some specific functions in neuron, glia and muscle cell models as it has been demonstrated over the last two decades.
Rosa Mancinelli +11 more
doaj +1 more source
Advanced Science, EarlyView.Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan +19 more
wiley +1 more source
Challenges of Ethiopian Researchers and Potential Mitigation with Ethiopian Science, Technology and Innovation Policy [PDF]
Most of the developed countries attain high-tech industry and economy by investing substantial amount of resources and by having a strong policy on research.
Tesfa, Belachew
core
Effect of GTP on the dissociation of 70 S ribosomes [PDF]
, 1969 Nélida S. González +2 more
openalex +1 more source
Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.
Genes & Development, 2011 Removal of the assembly factor eukaryotic initiation factor 6 (eIF6) is critical for late cytoplasmic maturation of 60S ribosomal subunits. In mammalian cells, the current model posits that eIF6 release is triggered following phosphorylation of Ser 235 ...
A. Finch +16 more
semanticscholar +1 more source
STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches
Advanced Science, EarlyView.This schematic outlines STING trafficking and signaling via coat protein II (COPII)‐mediated endoplasmic reticulum (ER) export. Following cyclic GMP‐AMP (cGAMP) stimulation, TANK‐binding kinase 1 (TBK1) activates on COPII vesicles, partially dissociating into the cytosol to phosphorylate ER‐localized STING, creating pSGME/pFS COPII‐sorting motifs ...
Yanan Nan +10 more
wiley +1 more source
Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis
Advanced Science, EarlyView.Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves +17 more
wiley +1 more source
Amino acid sequence of elongation factor Tu. Sequence of a region containing the thiol group essential for GTP binding [PDF]
, 1975 Michael S. Wade +2 more
openalex +1 more source
KRAS/ABHD17C/ALOX15B Axis Promotes Pancreatic Cancer Progression via Ferroptosis Evasion
Advanced Science, EarlyView.Phosphorylation of ABHD17C induced by KRASmut/ERK signaling facilitates ALOX15B depalmitoylation and degradation via the CUL4/DDB1/DCAF10 complex, thereby enabling KRASmut‐PDAC cell to evade ferroptosis. Methyl protodioscin inhibits KRASmut‐PDAC progression by disrupting the ABHD17C/ALOX15B interaction and inducing ferroptosis, which represents a ...
Man Li +12 more
wiley +1 more source
Differential translation of rabbit globin mRNA. Effect of concentrations of creatine phosphate, ATP and GTP [PDF]
, 1975 Haruo Suzuki, Yukimasa Hayashi
openalex +1 more source