Results 131 to 140 of about 386,929 (385)
Going in GTP cycles in the nucleolus [PDF]
The Journal of Cell Biology, 2005 Proteins are directed to cellular compartments by specific localization signals. A GTP-driven cycle has now been identified as a mechanism for protein targeting to the nucleolus. The involvement of a GTP switch suggests that nucleolar localization can be regulated and may be responsive to extracellular stimuli via signaling pathways.
openaire +2 more sources
A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines
Advanced Science, EarlyView.OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin +4 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2014 Background/Aims: Extracellular GTP is able to modulate some specific functions in neuron, glia and muscle cell models as it has been demonstrated over the last two decades.
Rosa Mancinelli +11 more
doaj +1 more source
Advanced Science, EarlyView.Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li +3 more
wiley +1 more source
Site‐Selective Peptide and Protein Functionalization with Cyclopropenium Cations
Angewandte Chemie, EarlyView.A cysteine‐selective bioconjugation using aromatic cyclopropenium cations is reported. The reaction proceeds rapidly under aqueous conditions, enabling site‐selective installation of tetrasubstituted cyclopropene rings on peptides and proteins. The method shows preference for internal cysteines and provides conjugates that serve as efficient radical ...
Adriana Faraone +6 more
wiley +2 more sources
Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.
Genes & Development, 2011 Removal of the assembly factor eukaryotic initiation factor 6 (eIF6) is critical for late cytoplasmic maturation of 60S ribosomal subunits. In mammalian cells, the current model posits that eIF6 release is triggered following phosphorylation of Ser 235 ...
A. Finch +16 more
semanticscholar +1 more source
Advanced Science, EarlyView.Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shuai Shao +10 more
wiley +1 more source
Transmembrane Transport of cAMP and AMP Using a Two Component Small Molecule Transport System
Angewandte Chemie, EarlyView.Transmembrane transport of the nucleotides cAMP (cyclic adenosine monophosphate) and AMP (adenosine monophosphate) is challenging, but can be achieved using a two‐component system consisting of a synthetic anionophore (e.g., squaramides) and a lipophilic thymine derivative.
Uththara M.C. Rathnaweera +7 more
wiley +2 more sources
Challenges of Ethiopian Researchers and Potential Mitigation with Ethiopian Science, Technology and Innovation Policy [PDF]
Most of the developed countries attain high-tech industry and economy by investing substantial amount of resources and by having a strong policy on research.
Tesfa, Belachew
core
Importin-β Is a GDP-to-GTP Exchange Factor of Ran [PDF]
, 2009 Thierry Lonhienne +5 more
openalex +1 more source