Results 151 to 160 of about 190,941 (249)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Unfolding ARF and ARL GTPases: from biophysics to systems-level insights. [PDF]

Front Mol Biosci
Quirion L, Strakhova R, Smith MJ, Côté JF.   +3 more
europepmc   +1 more source

Deciphering allosteric mechanisms in KRAS activation: insights from GTP-induced conformational dynamics and interaction network reorganization

Dongmei Zhao, Jingyu Yang, Meng-Ting Liu, Li-Quan Yang, Peng Sang   +4 more
openalex   +2 more sources

IMP dehydrogenase inhibitors reduce intracellular tetrahydrobiopterin levels through reduction of intracellular GTP levels. Indications of the regulation of GTP cyclohydrolase I activity by restriction of GTP availability in the cells.

, 1992
Kazuyuki Hatakeyama, T. Harada, Hiroyuki Kagamiyama   +2 more
openalex   +1 more source

Mu opioid receptor activation enhances regulator of G protein signaling 4 association with the mu opioid receptor/G protein complex in a GTP‐dependent manner [PDF]

, 2015
Rema Santhappan, Alicia T. Crowder, Shawn Gouty, Brian M. Cox, C. E. Thomas   +4 more
openalex   +1 more source

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Structural mechanism of mRNA decoding by mammalian GTPase GTPBP1. [PDF]

Nat Commun
Susorov D, Miścicka A, Golovenko D, Loveland AB, Zinoviev A, Pestova TV, Korostelev AA.   +6 more
europepmc   +1 more source

Lipopolysaccharide treatment in vivo induces tissue expression of GTP cyclohydrolase I mRNA [PDF]

, 1995
Yoshiyuki Hattori, Muneo Oka, Kikuo Kasai, Nobuo Nakanishi, Shin-Ichi Shimoda   +4 more
openalex   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Optimized conditions for GTP loading of Ras. [PDF]

J Biol Chem
Vish KJ, Paul ME, Rollins AP, Boggon TJ.
europepmc   +1 more source