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Monitoring cellular Guanosine triphosphate (GTP) and GTP associated proteins
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Physiological Reviews, 2001
Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and constitute a superfamily consisting of more than 100 members. This superfamily is structurally classified into at least five families: the Ras, Rho, Rab, Sar1/Arf, and Ran families.
Y, Takai, T, Sasaki, T, Matozaki
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Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and constitute a superfamily consisting of more than 100 members. This superfamily is structurally classified into at least five families: the Ras, Rho, Rab, Sar1/Arf, and Ran families.
Y, Takai, T, Sasaki, T, Matozaki
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Regulation of GTP biosynthesis
Advances in Enzyme Regulation, 1992In the regulation of GTP biosynthesis, complex interactions are observed. A major factor is the behavior of the activity of IMPDH, the rate-limiting enzyme of de novo GTP biosynthesis, and the activity of GPRT, the salvage enzyme of guanylate production. The activities of GMP synthase, GMP kinase and nucleoside-diphosphate kinase are also relevant.
G, Weber +4 more
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Annual Review of Cell and Developmental Biology, 2013
Shape changes and topological remodeling of membranes are essential for the identity of organelles and membrane trafficking. Although all cellular membranes have common features, membranes of different organelles create unique environments that support specialized biological functions.
James A, McNew +4 more
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Shape changes and topological remodeling of membranes are essential for the identity of organelles and membrane trafficking. Although all cellular membranes have common features, membranes of different organelles create unique environments that support specialized biological functions.
James A, McNew +4 more
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Interaction of liver plasma membranes and GTP with GTP hydrolysis
Biochemical and Biophysical Research Communications, 1973Abstract [ 14 C]GTP or a metabolic product of GTP binds to liver membranes. Less label was associated with membranes when membranes were incubated with increasing concentrations of carrier GTP; ATP did not displace the label. Chromatography of extracted incubation mixtures of [ 14 C]GTP and membranes revealed that over 96% of the nucleotide was ...
N I, Swislocki +2 more
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GDP/GTP Exchange Proteins for Small GTP-Binding Proteins
1993There is a superfamily of small GTP-binding proteins in which more than forty members are included (Bourne et al. 1991; Hall 1990; Takai et al. 1992). They exhibit GDP/GTP-binding and GTPase activities and have two interconvertible forms: GDP-bound inactive and GTP-bound active forms (Fig. 1).
Y. Takai +3 more
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Current Opinion in Structural Biology, 1991
Abstract There has been much progress this year in characterizing the complex series of post-translational modifications important for GTP-binding protein function. In addition, the long-awaited molecular characterization of a G protein that regulates phospholipase C activity has been reported.
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Abstract There has been much progress this year in characterizing the complex series of post-translational modifications important for GTP-binding protein function. In addition, the long-awaited molecular characterization of a G protein that regulates phospholipase C activity has been reported.
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