Results 1 to 10 of about 2,709 (164)

Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 1993
Cotransfection assays were used to show that the members of the GTP-binding protein Gq class of alpha subunits could activate phospholipase C (PLC) beta 2.
Katz, Arieh, Simon, Melvin I., Wu, Dianqing   +2 more
core   +2 more sources

G protein selectivity profile of GPR56/ADGRG1 and its effect on downstream effectors. [PDF]

Cell Mol Life Sci
GPR56, an adhesion G-protein coupled receptor (aGPCRs) with constitutive and ligand-promoted activity, is involved in many physiological and pathological processes.
Jallouli R, Moreno-Salinas AL, Laniel A, Holleran B, Avet C, Jacob J, Hoang T, Lavoie C, Carmon KS, Bouvier M, Leduc R.   +10 more
europepmc   +3 more sources

Stabilization of interdomain closure by a G protein inhibitor. [PDF]

Proc Natl Acad Sci U S A
Inhibitors of heterotrimeric G proteins are being developed as therapeutic agents. Epitomizing this approach are YM-254890 (YM) and FR900359 (FR), which are efficacious in models of thrombosis, hypertension, obesity, asthma, uveal melanoma, and pain, and
Todd TD, Vithani N, Singh S, Bowman GR, Blumer KJ, Soranno A.   +5 more
europepmc   +3 more sources

Selectivity and efficiency of receptor mediated G protein activation [PDF]

, 2020
G protein coupled receptors (GPCR) regulate many important physiological functions by converting extracellular stimuli into the variety of biological responses.
Ilyaskina, Olga
core   +1 more source

Role of G{alpha}12 and G{alpha}13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor [PDF]

, 2007
G{alpha}12 and G{alpha}13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response to oxidative stress.
Cho, Min Kyung, Choi, Sangdun, Hwang, Jong-Ik, Ki, Sung Hwan, Kim, Sang Geon, Kim, Won Dong, Lee, Chang Ho   +6 more
core   +2 more sources

Identification of two novel GTP-binding protein alpha-subunits that lack apparent ADP-ribosylation sites for pertussis toxin.

Journal of Biological Chemistry, 1991
Molecular cloning of cDNAs encoding alpha-subunits of guanine nucleotide-binding regulatory proteins (G-proteins) has revealed the existence of nine species of alpha-subunits.
F. Nakamura, K. Ogata, K. Shiozaki, K. Kameyama, K. Ôhara, T. Haga, T. Nukada   +6 more
semanticscholar   +1 more source

Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33–mediated macrophage polarization and emphysema [PDF]

, 2016
Heterotrimeric guanine nucleotide–binding protein (G protein) signaling is a ubiquitous signaling system that links hundreds of G protein–coupled receptors (GPCRs) with four G protein signaling pathways.
Habgood, Anthony, Jenkins, R. Gisli, John, Alison, E., Jolly, Lisa, Knox, Alan J., Miele, Gino, Offermanns, Stefan, Porte, Joanne, Stavrou, Anastasios, Takata, Masao, Tatler, Amanda L., Wilson, Michael, R.   +11 more
core   +2 more sources

Mitogenic signaling by Gq/11-coupled receptors [PDF]

, 2004
By binding to their cognate GPCRs, many potent mitogens such as neuropeptides, angiotensin II or lysophosphatidic acid stimulate cell proliferation via engaging the ERK/MAPK cascade. As mentioned before, agonists stimulating Gq/11-coupled
Carell, Thomas, Prof. Dr., Roelle, Susanne   +1 more
core   +1 more source

At least three alternatively spliced mRNAs encoding two alpha subunits of the Go GTP-binding protein can be expressed in a single tissue.

Journal of Biological Chemistry, 1990
Hybridization blot (Northern) analysis of mRNA coding for alpha subunits of the Go signal-transducing protein detects three bands at 5.7, 4.2, and 3.2 kilobases (kb). We showed previously that the largest is a splice variant coding for the type 2 form of
P. Bertrand, J. Sanford, U. Rudolph, J. Codina, L. Birnbaumer   +4 more
semanticscholar   +1 more source

Molecular aspects of WNT/Frizzled signalling in brain angiogenesis [PDF]

, 2017
The family of WNT lipoglycoproteins consists of 19 secreted proteins that are important for multiple cellular processes including cell proliferation, migration and fate.
Hot, Belma
core   +1 more source