Results 11 to 20 of about 2,709 (164)
Micromolar Affinity and Higher: Synthetic Host–Guest Complexes with High Stabilities
Angewandte Chemie International Edition, Volume 62, Issue 28, July 10, 2023., 2023 The review collects recent achievements in the design of 1 : 1 host–guest complexes with association constants exceeding 106 M−1. The relationships between the measured thermodynamic constants and the structural parameters of the interacting species are analyzed.
Sayan Sarkar +3 more
wiley +1 more source
RAS‐targeted cancer therapy: Advances in drugging specific mutations
MedComm, Volume 4, Issue 3, June 2023., 2023 Personalized therapeutic strategy targeting specific mut‐RAS‐induced cancers is essential. Cancer type, RAS mutation type, activation of downstream pathways, and clinicopathological background should be comprehensively considered when designing strategies for drug combinations.
Cen Liu +7 more
wiley +1 more source
Biological Reviews, Volume 97, Issue 1, Page 251-272, February 2022., 2022 ABSTRACT Sphingosine 1‐phosphate (S1P) is a bioactive sphingolipid metabolite, functioning as a signalling molecule in diverse cellular processes. Over the past few decades, studies of S1P signalling have revealed that the physiological activity of S1P largely depends on S1P metabolizing enzymes, transporters and receptors on the plasma membrane, as ...
Mengqiao Cui +2 more
wiley +1 more source
Ral GTPase–activating protein regulates the malignancy of pancreatic ductal adenocarcinoma
Cancer Science, Volume 112, Issue 8, Page 3064-3073, August 2021., 2021 Ral is a Ras family small GTPase that have recently been noted as a novel signaling factor that regulates progression of pancreatic ductal adenocarcinoma (PDAC). In this study, by characterizing newly generated RalGAP‐deficient PDAC cells, we first demonstrated that Ral GTPase–activating proteins played a critical role in not only cell migration and ...
Shingo Yoshimachi +15 more
wiley +1 more source
Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.
Journal of Biological Chemistry, 1987 Biochemical studies in vertebrate olfactory tissue indicate that certain odorants stimulate adenylyl cyclase in a GTP-dependent manner. Additionally, immunochemical and toxin-labeling studies demonstrate the presence of several GTP-binding protein (G ...
David T. Jones, R. Reed
semanticscholar +1 more source
Journal of Biological Chemistry, 1990 Novel G protein alpha subunits were purified from rat brain by an affinity matrix containing immobilized beta gamma subunits (Pang, I.-H., and Sternweis, P. C. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 7814-7818). They were unique based on the following
Iok Hou Pang, P. Sternweis
semanticscholar +1 more source
Mechanisms of Platelet Activation and Integrin αIIβ3 [PDF]
, 2012 Platelet aggregation is not only an essential part of hemostasis, but also initiates acute coronary syndrome or ischemic stroke. The precise understanding of the activation mechanism of platelet aggregation is fundamental for the development of more ...
Banno +42 more
core +2 more sources
Rhodopsin-enhanced GTPase activity of the inhibitory GTP-binding protein of adenylate cyclase.
Journal of Biological Chemistry, 1984 Work in several laboratories has shown that Gi, the inhibitory guanyl nucleotide-binding protein of the adenylate cyclase system, is similar in many ways to transducin, the guanyl nucleotide-binding protein of the retinal light-activated cGMP ...
Y. Kanaho +5 more
semanticscholar +1 more source
Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders [PDF]
, 2016 The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases ...
Aggarwal, M. +5 more
core +1 more source