G protein selectivity profile of GPR56/ADGRG1 and its effect on downstream effectors. [PDF]
Cell Mol Life SciGPR56, an adhesion G-protein coupled receptor (aGPCRs) with constitutive and ligand-promoted activity, is involved in many physiological and pathological processes.
Jallouli R +10 more
europepmc +3 more sources
Micromolar Affinity and Higher: Synthetic Host–Guest Complexes with High Stabilities
Angewandte Chemie International Edition, Volume 62, Issue 28, July 10, 2023., 2023 The review collects recent achievements in the design of 1 : 1 host–guest complexes with association constants exceeding 106 M−1. The relationships between the measured thermodynamic constants and the structural parameters of the interacting species are analyzed.
Sayan Sarkar +3 more
wiley +1 more source
RAS‐targeted cancer therapy: Advances in drugging specific mutations
MedComm, Volume 4, Issue 3, June 2023., 2023 Personalized therapeutic strategy targeting specific mut‐RAS‐induced cancers is essential. Cancer type, RAS mutation type, activation of downstream pathways, and clinicopathological background should be comprehensively considered when designing strategies for drug combinations.
Cen Liu +7 more
wiley +1 more source
Biological Reviews, Volume 97, Issue 1, Page 251-272, February 2022., 2022 ABSTRACT Sphingosine 1‐phosphate (S1P) is a bioactive sphingolipid metabolite, functioning as a signalling molecule in diverse cellular processes. Over the past few decades, studies of S1P signalling have revealed that the physiological activity of S1P largely depends on S1P metabolizing enzymes, transporters and receptors on the plasma membrane, as ...
Mengqiao Cui +2 more
wiley +1 more source
Ral GTPase–activating protein regulates the malignancy of pancreatic ductal adenocarcinoma
Cancer Science, Volume 112, Issue 8, Page 3064-3073, August 2021., 2021 Ral is a Ras family small GTPase that have recently been noted as a novel signaling factor that regulates progression of pancreatic ductal adenocarcinoma (PDAC). In this study, by characterizing newly generated RalGAP‐deficient PDAC cells, we first demonstrated that Ral GTPase–activating proteins played a critical role in not only cell migration and ...
Shingo Yoshimachi +15 more
wiley +1 more source
Selectivity and efficiency of receptor mediated G protein activation [PDF]
, 2020 G protein coupled receptors (GPCR) regulate many important physiological functions by converting extracellular stimuli into the variety of biological responses.
Ilyaskina, Olga
core +1 more source
Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts [PDF]
, 2005 Rho is a major small GTP-binding protein that is involved in the regulation of various cell functions, including proliferation and cell migration, through activation of multiple signaling molecules in various types of cells.
Kurose, Hitoshi +4 more
core +2 more sources
Role of G{alpha}12 and G{alpha}13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor [PDF]
, 2007 G{alpha}12 and G{alpha}13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response to oxidative stress.
Cho, Min Kyung +6 more
core +2 more sources
Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes [PDF]
, 2007 CD38 controls the chemotaxis of leukocytes to some, but not all, chemokines, suggesting that chemokine receptor signaling in leukocytes is more diverse than previously appreciated.
Borchers, Michael T. +7 more
core +2 more sources