Results 21 to 30 of about 2,286 (161)

Stabilization of interdomain closure by a G protein inhibitor. [PDF]

Proc Natl Acad Sci U S A
Inhibitors of heterotrimeric G proteins are being developed as therapeutic agents. Epitomizing this approach are YM-254890 (YM) and FR900359 (FR), which are efficacious in models of thrombosis, hypertension, obesity, asthma, uveal melanoma, and pain, and
Todd TD, Vithani N, Singh S, Bowman GR, Blumer KJ, Soranno A.   +5 more
europepmc   +3 more sources

Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33–mediated macrophage polarization and emphysema [PDF]

, 2016
Heterotrimeric guanine nucleotide–binding protein (G protein) signaling is a ubiquitous signaling system that links hundreds of G protein–coupled receptors (GPCRs) with four G protein signaling pathways.
Habgood, Anthony, Jenkins, R. Gisli, John, Alison, E., Jolly, Lisa, Knox, Alan J., Miele, Gino, Offermanns, Stefan, Porte, Joanne, Stavrou, Anastasios, Takata, Masao, Tatler, Amanda L., Wilson, Michael, R.   +11 more
core   +2 more sources

Mitogenic signaling by Gq/11-coupled receptors [PDF]

, 2004
By binding to their cognate GPCRs, many potent mitogens such as neuropeptides, angiotensin II or lysophosphatidic acid stimulate cell proliferation via engaging the ERK/MAPK cascade. As mentioned before, agonists stimulating Gq/11-coupled
Carell, Thomas, Prof. Dr., Roelle, Susanne   +1 more
core   +1 more source

Role of miRNA Let-7 and Its Major Targets in Prostate Cancer

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
Prostate cancer is worldwide the sixth leading cause of cancer related death in men thus early detection and successful treatment are still of major interest. The commonly performed screening of the prostate‐specific antigen (PSA) is controversially discussed, as in many patients the prostate‐specific antigen levels are chronically elevated in the ...
Siegfried Wagner, Anaclet Ngezahayo, Hugo Murua Escobar, Ingo Nolte, Andreas Doll   +4 more
wiley   +1 more source

Molecular aspects of WNT/Frizzled signalling in brain angiogenesis [PDF]

, 2017
The family of WNT lipoglycoproteins consists of 19 secreted proteins that are important for multiple cellular processes including cell proliferation, migration and fate.
Hot, Belma
core   +1 more source

Role of G Protein‐Coupled Receptors in Control of Dendritic Cell Migration

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
Dendritic cells (DCs) are highly efficient antigen‐presenting cells. The migratory properties of DCs give them the capacity to be a sentinel of the body and the vital role in the induction and regulation of adaptive immune responses. Therefore, it is important to understand the mechanisms in control of migration of DCs to lymphoid and nonlymphoid ...
Yuan Liu, Guixiu Shi, Mina Hur
wiley   +1 more source

Mechanisms of Platelet Activation and Integrin αIIβ3 [PDF]

, 2012
Platelet aggregation is not only an essential part of hemostasis, but also initiates acute coronary syndrome or ischemic stroke. The precise understanding of the activation mechanism of platelet aggregation is fundamental for the development of more ...
Banno, Becker, Bennett, Berridge, Brass, Braun, Chen, Chrzanowska-Wodnicka, Cifuni, Critchley, Crittenden, Di Virgilio, Dorsam, Gachet, Giannarelli, Han, Joo, Lafuente, Larjava, Lau, Lee, Lefkovits, Li, Li, Moser, Nguyen, Nieswandt, Nieswandt, Offermanns, Offermanns, Oury, Petrich, Quinn, Ruggeri, Seung-Jae Joo, Smyth, Stojanovic, Topol, Tricoci, Varga-Szabo, Watanabe, Woulfe, Zhang   +42 more
core   +2 more sources

Genetic and Biochemical Alterations in Non‐Small Cell Lung Cancer

Biochemistry Research International, Volume 2012, Issue 1, 2012., 2012
Despite significant advances in the detection and treatment of lung cancer, it causes the highest number of cancer‐related mortality. Recent advances in the detection of genetic alterations in patient samples along with physiologically relevant animal models has yielded a new understanding of the molecular etiology of lung cancer.
Jackie L. Johnson, Smitha Pillai, Srikumar P. Chellappan, Eun-Kyoung Yim Breuer   +3 more
wiley   +1 more source

Signal Protein‐Derived Peptides as Functional Probes and Regulators of Intracellular Signaling

Journal of Amino Acids, Volume 2011, Issue 1, 2011., 2011
The functionally important regions of signal proteins participating in their specific interaction and responsible for transduction of hormonal signal into cell are rather short in length, having, as a rule, 8 to 20 amino acid residues. Synthetic peptides corresponding to these regions are able to mimic the activated form of full‐size signal protein and
Alexander O. Shpakov, Andrei Malkov
wiley   +1 more source

The angiotensin II AT(1), receptor structure-activity correlations in the light of rhodopsin structure [PDF]

, 2007
The most prevalent physiological effects of ANG II, the main product of the renin-angiotensin system, are mediated by the AT(1) receptor, a rhodopsin-like AGPCR.
Costa-Neto, Claudio M., Nakaie, Clovis R., Oliveira, Laerte, Paiva, Antonio C. M., Schreier, Shirley, Shimuta, Suma I.   +5 more
core   +1 more source