Results 21 to 30 of about 2,709 (164)

Role of miRNA Let-7 and Its Major Targets in Prostate Cancer

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
Prostate cancer is worldwide the sixth leading cause of cancer related death in men thus early detection and successful treatment are still of major interest. The commonly performed screening of the prostate‐specific antigen (PSA) is controversially discussed, as in many patients the prostate‐specific antigen levels are chronically elevated in the ...
Siegfried Wagner, Anaclet Ngezahayo, Hugo Murua Escobar, Ingo Nolte, Andreas Doll   +4 more
wiley   +1 more source

The angiotensin II AT(1), receptor structure-activity correlations in the light of rhodopsin structure [PDF]

, 2007
The most prevalent physiological effects of ANG II, the main product of the renin-angiotensin system, are mediated by the AT(1) receptor, a rhodopsin-like AGPCR.
Costa-Neto, Claudio M., Nakaie, Clovis R., Oliveira, Laerte, Paiva, Antonio C. M., Schreier, Shirley, Shimuta, Suma I.   +5 more
core   +1 more source

Role of G Protein‐Coupled Receptors in Control of Dendritic Cell Migration

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
Dendritic cells (DCs) are highly efficient antigen‐presenting cells. The migratory properties of DCs give them the capacity to be a sentinel of the body and the vital role in the induction and regulation of adaptive immune responses. Therefore, it is important to understand the mechanisms in control of migration of DCs to lymphoid and nonlymphoid ...
Yuan Liu, Guixiu Shi, Mina Hur
wiley   +1 more source

Genetic and Biochemical Alterations in Non‐Small Cell Lung Cancer

Biochemistry Research International, Volume 2012, Issue 1, 2012., 2012
Despite significant advances in the detection and treatment of lung cancer, it causes the highest number of cancer‐related mortality. Recent advances in the detection of genetic alterations in patient samples along with physiologically relevant animal models has yielded a new understanding of the molecular etiology of lung cancer.
Jackie L. Johnson, Smitha Pillai, Srikumar P. Chellappan, Eun-Kyoung Yim Breuer   +3 more
wiley   +1 more source

A frizzled quest to dissect the molecular pharmacology of WNT signaling : from biology to signaling mechanism(s) [PDF]

, 2017
The wingless/int1 (WNT)/Frizzled (FZD) family of signal transduction pathways is highly conserved across species and controls essential physiological functions important for embryonic development, stem cell renewal, proliferation, differentiation, and ...
Arthofer, Elisa
core   +1 more source

Signal Protein‐Derived Peptides as Functional Probes and Regulators of Intracellular Signaling

Journal of Amino Acids, Volume 2011, Issue 1, 2011., 2011
The functionally important regions of signal proteins participating in their specific interaction and responsible for transduction of hormonal signal into cell are rather short in length, having, as a rule, 8 to 20 amino acid residues. Synthetic peptides corresponding to these regions are able to mimic the activated form of full‐size signal protein and
Alexander O. Shpakov, Andrei Malkov
wiley   +1 more source

G-Protein coupled receptor signalling in pluripotent stem cell-derived cardiovascular cells: Implications for disease modelling [PDF]

, 2015
Human pluripotent stem cell derivatives show promise as an in vitro platform to study a range of human cardiovascular diseases. A better understanding of the biology of stem cells and their cardiovascular derivatives will help to understand the strengths
Dolatshad, NF, Foldes, G, Harding, SE, Hellen, N, Jabbour, R   +4 more
core   +1 more source

Chemotactic peptide receptor-supported ADP-ribosylation of a pertussis toxin substrate GTP-binding protein by cholera toxin in neutrophil-type HL-60 cells.

Journal of Biological Chemistry, 1989
A 40-kDa protein, in addition to the alpha-subunits of Gs (a GTP-binding protein involved in adenylate cyclase stimulation), was [32P]ADP-ribosylated by cholera toxin (CT) in the membranes of neutrophil-like HL-60 cells, only if formyl Met-Leu-Phe (fMLP)
T. Iiri, M. Tohkin, N. Morishima, Y. Ohoka, M. Ui, T. Katada   +5 more
semanticscholar   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, Volume 12, Issue 30, August 14, 2025.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

Regulation of Rho-activating proteins by heterotrimeric G proteins: Sensitivity of Gα RhoGEF interaction is determined by dissociation kinetics [PDF]

, 2014
Activation of RhoGTPases downstream of G protein coupled receptors is important for many physiological functions, such as blood pressure regulation. The subfamilies Rho, Rac and Cdc42 are the best understood RhoGTPases and the present study focused on ...
Bodmann, Eva-Lisa
core   +1 more source