Gα12 and Gα13 subunits define a fourth class of G protein α subunits [PDF]
, 1991 Heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) are central to the signaling processes of multicellular organisms. We have explored the diversity of the G protein subunits in mammals and found evidence for a large family of ...
Simon, Melvin I., Strathmann, Michael P.
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Inactivating mutations in GNA13 and RHOA in Burkitt’s lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells [PDF]
, 2015 G proteins and their cognate G protein-coupled receptors (GPCRs) function as critical signal transduction molecules that regulate cell survival, proliferation, motility and differentiation.
Aoki, J +15 more
core +2 more sources
RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists. [PDF]
, 2018 Platelets express ≥2 members of the regulators of G protein signaling (RGS) family. Here, we have focused on the most abundant, RGS10, examining its impact on the hemostatic response in vivo and the mechanisms involved.
Brass, Lawrence F. +7 more
core +1 more source
The GTP-binding protein of rod outer segments. I. Role of each subunit in the GTP hydrolytic cycle.
Journal of Biological Chemistry, 1987 The GTP-binding protein of Bufo marinus rod outer segments (ROS) is composed of 3 subunits: G alpha, 39,000; G beta, 36,000; and G gamma, approximately 6,500.
A. Yamazaki +3 more
semanticscholar +1 more source
Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +2 more sources
MOLECULAR PHYSIOLOGY OF THROMBOXANE A2 GENERATION IN PLATELETS [PDF]
, 2010 Cardiovascular diseases are a major cause of mortality and morbidity in the developed countries. Anti-platelet therapy is a cornerstone treatment for patients with cardiovascular diseases.
Bhavaraju, Kamala
core +1 more source
Identification of a new GTP-binding protein. A Mr = 43,000 substrate for pertussis toxin.
Journal of Biological Chemistry, 1987 In purified preparations of human erythrocyte GTP-binding proteins, we have identified a new substrate for pertussis toxin, which has an apparent molecular mass of 43 kDa by silver and Coomassie Blue staining.
R. Iyengar +5 more
semanticscholar +1 more source
Molecular Determinants of Orexin Receptor Ligand Interaction : Studies on Ligand Selectivity and Impact of Calcium [PDF]
, 2014 Neuropeptides orexin-A and orexin-B, and their receptors OX1 and OX2 were first found as regulators of appetite, and later several other functions have been found as well.
Putula, Jaana
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Analysis of Gq/G11 and G12/G13 mediated signalling in the endothelial functions [PDF]
, 2008 In this study, I analyzed the role of GPCR signalling pathways mediated by Gq/G11 and G12/G13 in the functions of the adult endothelium. To achieve endothelium specific deletion of G-alpha-q/11 and G-alpha-12/13, I crossed an inducible Tie2-Cre mouse ...
Korhonen, Hanna
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Analysis of diverse signal transduction pathways using the genetic model system Caenorhabditis elegans [PDF]
, 2003 Signal transduction allows cells to respond to signals from their environment and is therefore important for most biological processes. The binding of an extracellular signalling molecule to a cell-surface receptor is the first step in most signal ...
Moorman, Celine
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